Korean Circulation Journal

  • 제46권6호
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  • Pages.834-840
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  • 2016
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  • 1738-5520(pISSN)
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  • 1738-5555(eISSN)
대한심장학회 (The Korean Society of Cardiology)
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Resting Heart Rate and Aortic Stiffness in Normotensive Adults

  • Logan, Jeongok G. (School of Nursing, University of Virginia) ;
  • Kim, Suk-Sun (College of Nursing, Ewha Womans University)
  • 투고 : 2015.12.29
  • 심사 : 2016.04.12
  • 발행 : 2016.11.30
⟨ 이전 논문 다음 논문 ⟩

초록

Background and Objective: Large-artery stiffness is an independent predictor of cardiovascular disease (CVD), and carotid-femoral pulse wave velocity (cfPWV) is considered the gold standard measure of arterial stiffness. A resting heart rate is an easily measured vital sign that is also associated with CVD morbidity and mortality. Previous studies have reported the significant relationship of a resting heart rate with arterial stiffness as measured by cfPWV only in hypertensive subjects; their relationship in nonhypertensive subjects remains unknown. The present study, therefore, examined their relationship in normotensive subjects. Subjects and Methods: In 102 healthy Korean Americans between ages 20 and 60 years, their resting heart rate was measured by an automated blood pressure measuring device after a 10 minute rest in the supine position. Arterial stiffness was measured by cfPWV using the SphygmoCor device. Results: The mean resting heart rate of participants (mean age, 39.64 years; 59% women) was 61.91 bpm (standard deviation [SD], 9.62 bpm) and mean the cfPWV was 6.99 (SD, 1.14) m/s. A multiple regression analysis showed that a resting heart rate is a significant predictor of cfPWV after controlling for age, body mass index, and mean arterial pressure. For one bpm increase of resting heart rate, cfPWV increased approximately 0.02 m/s. Conclusion: Our results suggest that a higher resting heart rate is independently associated with increased arterial stiffness as measured by cfPWV in normotensive adults. Arterial stiffness may explain the prognostic role of an individual's heart rate in cardiovascular morbidity and mortality.

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참고문헌

  1. Chung CM, Lin YS, Chu CM, et al. Arterial stiffness is the independent factor of left ventricular hypertrophy determined by electrocardiogram. Am J Med Sci 2012;344:190-3. https://doi.org/10.1097/MAJ.0b013e318242a354
  2. Dernellis J, Panaretou M. Aortic stiffness is an independent predictor of progression to hypertension in nonhypertensive subjects. Hypertension 2005;45:426-31. https://doi.org/10.1161/01.HYP.0000157818.58878.93
  3. Laurent S, Cockcroft J, Van Bortel L, et al. Expert consensus document on arterial stiffness: methodological issues and clinical applications. Eur Heart J 2006;27:2588-605. https://doi.org/10.1093/eurheartj/ehl254
  4. Palatini P, Dorigatti F, Zaetta V, et al. Heart rate as a predictor of development of sustained hypertension in subjects screened for stage 1 hypertension: the HARVEST Study. J Hypertens 2006;24:1873-80. https://doi.org/10.1097/01.hjh.0000242413.96277.5b
  5. Bonaa KH, Arnesen E. Association between heart rate and atherogenic blood lipid fractions in a population. The tromoso study. Circulation 1992;86:394-405. https://doi.org/10.1161/01.CIR.86.2.394
  6. Hozawa A, Ohkubo T, Kikuya M, et al. Prognostic value of home heart rate for cardiovascular mortality in the general population: the Ohasama study. Am J Hypertens 2004;17(11 Pt 1):1005-10.
  7. Palatini P, Thijs L, Staessen JA, et al. Predictive value of clinic and ambulatory heart rate for mortality in elderly subjects with systolic hypertension. Arch Intern Med 2002;162:2313-21. https://doi.org/10.1001/archinte.162.20.2313
  8. Palatini P, Parati G. Persistently elevated heart rate accelerates the progression of arterial stiffness. J Hypertens 2010;28:653-6. https://doi.org/10.1097/HJH.0b013e3283389e3d
  9. Whelton SP, Blankstein R, Al-Mallah MH, et al. Association of resting heart rate with carotid and aortic arterial stiffness: multi-ethnic study of atherosclerosis. Hypertension 2013;62:477-84. https://doi.org/10.1161/HYPERTENSIONAHA.113.01605
  10. Lantelme P, Mestre C, Lievre M, Gressard A, Milon H. Heart rate: an important confounder of pulse wave velocity assessment. Hypertension 2002;39:1083-7. https://doi.org/10.1161/01.HYP.0000019132.41066.95
  11. Wilkinson IB, Mohammad NH, Tyrrell S, et al. Heart rate dependency of pulse pressure amplification and arterial stiffness. Am J Hypertens 2002;15(1 Pt 1):24-30. https://doi.org/10.1016/S0895-7061(01)02252-X
  12. Sa Cunha R, Pannier B, Benetos A, et al. Association between high heart rate and high arterial rigidity in normotensive and hypertensive subjects. J Hypertens 1997;15(12 Pt 1):1423-30. https://doi.org/10.1097/00004872-199715120-00009
  13. Avolio A, Butlin M, Tan I. Importance of pressure pulse amplification in the association of resting heart rate and arterial stiffness. Hypertension 2013;62:e46. https://doi.org/10.1161/HYPERTENSIONAHA.113.02260
  14. Tomiyama H, Hashimoto H, Tanaka H, et al. Synergistic relationship between changes in the pulse wave velocity and changes in the heart rate in middle-aged Japanese adults: a prospective study. J Hypertens 2010;28:687-94. https://doi.org/10.1097/HJH.0b013e3283369fe8
  15. Albaladejo P, Asmar R, Safar M, Benetos A. Association between 24-hour ambulatory heart rate and arterial stiffness. J Hum Hypertens 2000;14:137-41. https://doi.org/10.1038/sj.jhh.1000961
  16. Benetos A, Adamopoulos C, Bureau JM, et al. Determinants of accelerated progression of arterial stiffness in normotensive subjects and in treated hypertensive subjects over a 6-year period. Circulation 2002;105:1202-7. https://doi.org/10.1161/hc1002.105135
  17. Albaladejo P, Laurent P, Pannier B, Achimastos A, Safar M, Benetos A. Influence of sex on the relation between heart rate and aortic stiffness. J Hypertens 2003;21:555-62. https://doi.org/10.1097/00004872-200303000-00021
  18. Albaladejo P, Copie X, Boutouyrie P, et al. Heart rate, arterial stiffness, and wave reflections in paced patients. Hypertension 2001;38:949-52. https://doi.org/10.1161/hy1001.096210
  19. Palatini P, Winnicki M, Santonastaso M, et al. Reproducibility of heart rate measured in the clinic and with 24-hour intermittent recorders. Am J Hypertens 2000;13(1 Pt 1):92-8. https://doi.org/10.1016/S0895-7061(99)00170-3
  20. Hozawa A, Ohkubo T, Kikuya M, et al. Prognostic value of home heart rate for cardiovascular mortality in the general population: the Ohasama study. Am J Hypertens 2004;17(11 Pt 1):1005-10.
  21. Grippo AJ, Johnson AK. Stress, depression and cardiovascular dysregulation: a review of neurobiological mechanisms and the integration of research from preclinical disease models. Stress 2009;12:1-21. https://doi.org/10.1080/10253890802046281
  22. Amiya E, Watanabe M, Takeda N, et al. Angiotensin II impairs endothelial nitric-oxide synthase bioavailability under free cholesterol-enriched conditions via intracellular free cholesterol-rich membrane microdomains. J Biol Chem 2013;288:14497-509. https://doi.org/10.1074/jbc.M112.448522
  23. Hornig B, Kohler C, Drexler H. Role of bradykinin in mediating vascular effects of angiotensin-converting enzyme inhibitors in humans. Circulation 1997;95:1115-8. https://doi.org/10.1161/01.CIR.95.5.1115
  24. Kawahara H, Kawahara Y, Westerink BH. The role of afferents to the locus coeruleus in the handling stress-induced increase in the release of noradrenaline in the medial prefrontal cortex: a dual-probe microdialysis study in the rat brain. Eur J Pharmacol 2000;387:279-86. https://doi.org/10.1016/S0014-2999(99)00793-1
  25. Yasmin, McEniery CM, Wallace S, et al. Matrix metalloproteinase-9 (MMP-9), MMP-2, and serum elastase activity are associated with systolic hypertension and arterial stiffness. Arterioscler Thromb Vasc Biol 2005;25:372.
  26. Tan J, Hua Q, Xing X, Wen J, Liu R, Yang Z. Impact of the metalloproteinase-9/tissue inhibitor of metalloproteinase-1 system on large arterial stiffness in patients with essential hypertension. Hypertens Res 2007;30:959-63. https://doi.org/10.1291/hypres.30.959
  27. Hu Z, Wang Z, Wu H, et al. Ang II enhances noradrenaline release from sympathetic nerve endings thus contributing to the upregulation of metalloprotease-2 in aortic dissection patients' aorta wall. PLoS One 2013;8:e76922. https://doi.org/10.1371/journal.pone.0076922
  28. Yang EV, Bane CM, MacCallum RC, Kiecolt-Glaser JK, Malarkey WB, Glaser R. Stress-related modulation of matrix metalloproteinase expression. J Neuroimmunol 2002;133:144-50. https://doi.org/10.1016/S0165-5728(02)00270-9
  29. Chen W, Li S, Fernandez C, et al. Temporal relationship between elevated blood pressure and arterial stiffening among middle-aged black and white adults: The bogalusa heart study. Am J Epidemiol 2016;183:599-608. https://doi.org/10.1093/aje/kwv274
  30. Kwon O, Park S, Kim YJ, et al. The exercise heart rate profile in master athletes compared to healthy controls. Clin Physiol Funct Imaging 2016;36:286-92. https://doi.org/10.1111/cpf.12226

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