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Epidemiology of Lung Cancer in Korea: Recent Trends

  • Park, Ji Young (Division of Pulmonary, Department of Internal Medicine, The Armed Forces Daejeon Hospital) ;
  • Jang, Seung Hun (Division of Pulmonary, Allergy and Critical Care Medicine, Department of Internal Medicine, Hallym University Sacred Heart Hospital)
  • Received : 2015.12.04
  • Accepted : 2015.12.14
  • Published : 2016.03.31

Abstract

Lung cancer causes the most cancer deaths in Korea. Although the smoking rate has begun to decrease, the prevalence of lung cancer is still increasing. We reviewed the national lung cancer registry data and the data published about lung cancer in Korea. In 2012, the crude incidence rate of lung cancer was 43.9 per 100,000. The age-standardized mortality rate of lung cancer was 19.8 per 100,000. The 5-year relative survival rate for lung cancer was 11.3% from 1993 to 1995 and increased to 21.9% in the period from 2008 to 2012. Lung cancer occurring in never-smokers was estimated to increase in Korea. Adenocarcinoma is steadily increasing in both women and men and has replaced squamous cell carcinoma as the most common type of lung cancer in Korea. In patients with adenocarcinoma, the frequency of EGFR mutations was 43% (range, 20%-56%), while that of the EMK4-ALK gene was less than 5%.

Keywords

References

  1. Global Burden of Disease Cancer Collaboration, Fitzmaurice C, Dicker D, Pain A, Hamavid H, Moradi-Lakeh M, et al. The global burden of cancer 2013. JAMA Oncol 2015;1:505-27. https://doi.org/10.1001/jamaoncol.2015.0735
  2. Korea Central Cancer Registry. Annual report of cancer statistics in Korea in 2012 [Internet]. Goyang: National Cancer Information Center; 2015 [cited 2015 Mar 31]. Available from: http://www.cancer.go.kr/.
  3. In KH, Kwon YS, Oh IJ, Kim KS, Jung MH, Lee KH, et al. Lung cancer patients who are asymptomatic at diagnosis show favorable prognosis: a Korean Lung Cancer Registry Study. Lung Cancer 2009;64:232-7. https://doi.org/10.1016/j.lungcan.2008.08.005
  4. Park JH, Lee KS, Choi KS. Burden of cancer in Korea during 2000-2020. Cancer Epidemiol 2013;37:353-9. https://doi.org/10.1016/j.canep.2013.03.015
  5. World DataBank. World development indicators [Internet]. Washington, DC: The World Bank Group; 2015 [cited 2015 Nov 11]. Available from: http://databank.worldbank.org/ddp/home.do.
  6. Planchard D, Besse B. Lung cancer in never-smokers. Eur Respir J 2015;45:1214-7. https://doi.org/10.1183/09031936.00046915
  7. Wakelee HA, Chang ET, Gomez SL, Keegan TH, Feskanich D, Clarke CA, et al. Lung cancer incidence in never smokers. J Clin Oncol 2007;25:472-8. https://doi.org/10.1200/JCO.2006.07.2983
  8. Kang H, Park CW, Kim W, Song SY, Na KJ, Jeong JU, et al. Never-smoker lung cancer is increasing. J Lung Cancer 2012;11: 89-93. https://doi.org/10.6058/jlc.2012.11.2.89
  9. Couraud S, Souquet PJ, Paris C, Do P, Doubre H, Pichon E, et al. BioCAST/IFCT-1002: epidemiological and molecular features of lung cancer in never-smokers. Eur Respir J 2015;45: 1403-14. https://doi.org/10.1183/09031936.00097214
  10. Ha SY, Choi SJ, Cho JH, Choi HJ, Lee J, Jung K, et al. Lung cancer in never-smoker Asian females is driven by oncogenic mutations, most often involving EGFR. Oncotarget 2015;6: 5465-74. https://doi.org/10.18632/oncotarget.2925
  11. Korean Statistical Information Service. Statistics Korea [Internet]. Daejeon: Statistics Korea; 2015 [cited 2015 Sep 23]. Available from: http://kosis.kr/.
  12. Gloeckler Ries LA, Reichman ME, Lewis DR, Hankey BF, Edwards BK. Cancer survival and incidence from the Surveillance, Epidemiology, and End Results (SEER) program. Oncologist 2003;8:541-52. https://doi.org/10.1634/theoncologist.8-6-541
  13. Lortet-Tieulent J, Soerjomataram I, Ferlay J, Rutherford M, Weiderpass E, Bray F. International trends in lung cancer incidence by histological subtype: adenocarcinoma stabilizing in men but still increasing in women. Lung Cancer 2014;84:13-22. https://doi.org/10.1016/j.lungcan.2014.01.009
  14. Zhou C. Lung cancer molecular epidemiology in China: recent trends. Transl Lung Cancer Res 2014;3:270-9.
  15. Toyoda Y, Nakayama T, Ioka A, Tsukuma H. Trends in lung cancer incidence by histological type in Osaka, Japan. Jpn J Clin Oncol 2008;38:534-9. https://doi.org/10.1093/jjco/hyn072
  16. Gray N. The consequences of the unregulated cigarette. Tob Control 2006;15:405-8. https://doi.org/10.1136/tc.2006.017277
  17. Marugame T, Sobue T, Nakayama T, Suzuki T, Kuniyoshi H, Sunagawa K, et al. Filter cigarette smoking and lung cancer risk: a hospital-based case: control study in Japan. Br J Cancer 2004;90:646-51. https://doi.org/10.1038/sj.bjc.6601565
  18. Dela Cruz CS, Tanoue LT, Matthay RA. Lung cancer: epidemiology, etiology, and prevention. Clin Chest Med 2011;32:605-44. https://doi.org/10.1016/j.ccm.2011.09.001
  19. Kenfield SA, Wei EK, Stampfer MJ, Rosner BA, Colditz GA. Comparison of aspects of smoking among the four histological types of lung cancer. Tob Control 2008;17:198-204. https://doi.org/10.1136/tc.2007.022582
  20. Ahn MJ, Lee J, Park YH, Ahn JS, Ziogas A, Zell JA, et al. Korean ethnicity as compared with white ethnicity is an independent favorable prognostic factor for overall survival in non-small cell lung cancer before and after the oral epidermal growth factor receptor tyrosine kinase inhibitor era. J Thorac Oncol 2010;5:1185-96. https://doi.org/10.1097/JTO.0b013e3181e2f624
  21. Jung KW, Won YJ, Kong HJ, Oh CM, Cho H, Lee DH, et al. Cancer statistics in Korea: incidence, mortality, survival, and prevalence in 2012. Cancer Res Treat 2015;47:127-41. https://doi.org/10.4143/crt.2015.060
  22. Allemani C, Weir HK, Carreira H, Harewood R, Spika D, Wang XS, et al. Global surveillance of cancer survival 1995-2009: analysis of individual data for 25,676,887 patients from 279 population-based registries in 67 countries (CONCORD-2). Lancet 2015;385:977-1010. https://doi.org/10.1016/S0140-6736(14)62038-9
  23. Alberg AJ, Brock MV, Ford JG, Samet JM, Spivack SD. Epidemiology of lung cancer: diagnosis and management of lung cancer, 3rd ed: American College of Chest Physicians evidence-based clinical practice guidelines. Chest 2013;143(5 Suppl):e1S-29S. https://doi.org/10.1378/chest.12-2345
  24. Howlader N, Noone AM, Krapcho M, Garshell J, Miller D, Altekruse SF, et al. SEER cancer statistics review, 1975-2012. Bethesda: National Cancer Institute; 2015.
  25. Donington JS, Colson YL. Sex and gender differences in nonsmall cell lung cancer. Semin Thorac Cardiovasc Surg 2011; 23:137-45. https://doi.org/10.1053/j.semtcvs.2011.07.001
  26. Wang LE, Yin M, Dong Q, Stewart DJ, Merriman KW, Amos CI, et al. DNA repair capacity in peripheral lymphocytes predicts survival of patients with non-small-cell lung cancer treated with first-line platinum-based chemotherapy. J Clin Oncol 2011;29:4121-8. https://doi.org/10.1200/JCO.2010.34.3616
  27. Soo RA, Loh M, Mok TS, Ou SH, Cho BC, Yeo WL, et al. Ethnic differences in survival outcome in patients with advanced stage non-small cell lung cancer: results of a meta-analysis of randomized controlled trials. J Thorac Oncol 2011;6:1030-8. https://doi.org/10.1097/JTO.0b013e3182199c03
  28. Ou SH, Ziogas A, Zell JA. Asian ethnicity is a favorable prognostic factor for overall survival in non-small cell lung cancer (NSCLC) and is independent of smoking status. J Thorac Oncol 2009;4:1083-93. https://doi.org/10.1097/JTO.0b013e3181b27b15
  29. Gandara DR, Kawaguchi T, Crowley J, Moon J, Furuse K, Kawahara M, et al. Japanese-US common-arm analysis of paclitaxel plus carboplatin in advanced non-small-cell lung cancer: a model for assessing population-related pharmacogenomics. J Clin Oncol 2009;27:3540-6. https://doi.org/10.1200/JCO.2008.20.8793
  30. Yun YH, Lim MK, Jung KW, Bae JM, Park SM, Shin SA, et al. Relative and absolute risks of cigarette smoking on major histologic types of lung cancer in Korean men. Cancer Epidemiol Biomarkers Prev 2005;14:2125-30. https://doi.org/10.1158/1055-9965.EPI-05-0236
  31. Lee PN, Forey BA, Coombs KJ. Systematic review with metaanalysis of the epidemiological evidence in the 1900s relating smoking to lung cancer. BMC Cancer 2012;12:385. https://doi.org/10.1186/1471-2407-12-385
  32. Janjigian YY, McDonnell K, Kris MG, Shen R, Sima CS, Bach PB, et al. Pack-years of cigarette smoking as a prognostic factor in patients with stage IIIB/IV nonsmall cell lung cancer. Cancer 2010;116:670-5. https://doi.org/10.1002/cncr.24813
  33. Kogure Y, Ando M, Saka H, Chiba Y, Yamamoto N, Asami K, et al. Histology and smoking status predict survival of patients with advanced non-small-cell lung cancer. Results of West Japan Oncology Group (WJOG) Study 3906L. J Thorac Oncol 2013;8:753-8. https://doi.org/10.1097/JTO.0b013e31828b51f5
  34. Yano T, Haro A, Shikada Y, Maruyama R, Maehara Y. Nonsmall cell lung cancer in never smokers as a representative 'non-smoking-associated lung cancer': epidemiology and clinical features. Int J Clin Oncol 2011;16:287-93. https://doi.org/10.1007/s10147-010-0160-8
  35. Couraud S, Zalcman G, Milleron B, Morin F, Souquet PJ. Lung cancer in never smokers: a review. Eur J Cancer 2012;48:1299-311. https://doi.org/10.1016/j.ejca.2012.03.007
  36. Bae JM. Modifiable risk factors of lung cancer in neversmoker women. Epidemiol Health 2015 Oct 29 [Epub]. http://dx.doi.org/10.4178/epih/e2015047.
  37. Hackshaw AK, Law MR, Wald NJ. The accumulated evidence on lung cancer and environmental tobacco smoke. BMJ 1997; 315:980-8. https://doi.org/10.1136/bmj.315.7114.980
  38. Zhong L, Goldberg MS, Parent ME, Hanley JA. Exposure to environmental tobacco smoke and the risk of lung cancer: a meta-analysis. Lung Cancer 2000;27:3-18. https://doi.org/10.1016/S0169-5002(99)00093-8
  39. Nordquist LT, Simon GR, Cantor A, Alberts WM, Bepler G. Improved survival in never-smokers vs current smokers with primary adenocarcinoma of the lung. Chest 2004;126:347-51. https://doi.org/10.1378/chest.126.2.347
  40. Quoix E, Monnet I, Scheid P, Hamadouche A, Chouaid C, Massard G, et al. Management and outcome of French elderly patients with lung cancer: an IFCT survey. Rev Mal Respir 2010;27:421-30. https://doi.org/10.1016/j.rmr.2010.02.013
  41. Toh CK, Gao F, Lim WT, Leong SS, Fong KW, Yap SP, et al. Never-smokers with lung cancer: epidemiologic evidence of a distinct disease entity. J Clin Oncol 2006;24:2245-51. https://doi.org/10.1200/JCO.2005.04.8033
  42. Kawaguchi T, Takada M, Kubo A, Matsumura A, Fukai S, Tamura A, et al. Gender, histology, and time of diagnosis are important factors for prognosis: analysis of 1499 neversmokers with advanced non-small cell lung cancer in Japan. J Thorac Oncol 2010;5:1011-7. https://doi.org/10.1097/JTO.0b013e3181dc213e
  43. Straif K, Cohen A, Samet J. Air pollution and cancer [Internet]. Lyon: International Agency for Research on Cancer; 2013 [cited 2015 Nov 11]. Available from: http://www.iarc.fr/en/publications/books/sp161/AirPollutionandCancer161.pdf.
  44. Gallus S, Negri E, Boffetta P, McLaughlin JK, Bosetti C, La Vecchia C. European studies on long-term exposure to ambient particulate matter and lung cancer. Eur J Cancer Prev 2008; 17:191-4. https://doi.org/10.1097/CEJ.0b013e3282f0bfe5
  45. Katanoda K, Sobue T, Satoh H, Tajima K, Suzuki T, Nakatsuka H, et al. An association between long-term exposure to ambient air pollution and mortality from lung cancer and respiratory diseases in Japan. J Epidemiol 2011;21:132-43. https://doi.org/10.2188/jea.JE20100098
  46. Hwang SS, Lee JH, Jung GW, Lim JH, Kwon HJ. Spatial analysis of air pollution and lung cancer incidence and mortality in 7 metropolitan cities in Korea. J Prev Med Public Health 2007; 40:233-8. https://doi.org/10.3961/jpmph.2007.40.3.233
  47. Sung JH, Cho SH, Kang DH, Yoo KY. Lung cancer, chronic obstructive pulmonary disease and air pollution. Korean J Prev Med 1997;30:585-98.
  48. Desai MA, Mehta S, Smith KR. Indoor smoke from solid fuels: assessing the environmental burden of disease at national and local levels [Internet]. Geneva: World Health Organization; 2004 [cited 2015 Nov 11.] Available from: http://www.who.int/quantifying_ehimpacts/publications/en/Indoorsmoke.pdf.
  49. Lissowska J, Bardin-Mikolajczak A, Fletcher T, Zaridze D, Szeszenia-Dabrowska N, Rudnai P, et al. Lung cancer and indoor pollution from heating and cooking with solid fuels: the IARC international multicentre case-control study in Eastern/Central Europe and the United Kingdom. Am J Epidemiol 2005;162:326-33. https://doi.org/10.1093/aje/kwi204
  50. Zhao Y, Wang S, Aunan K, Seip HM, Hao J. Air pollution and lung cancer risks in China: a meta-analysis. Sci Total Environ 2006;366:500-13. https://doi.org/10.1016/j.scitotenv.2005.10.010
  51. Yu IT, Chiu YL, Au JS, Wong TW, Tang JL. Dose-response relationship between cooking fumes exposures and lung cancer among Chinese nonsmoking women. Cancer Res 2006;66: 4961-7. https://doi.org/10.1158/0008-5472.CAN-05-2932
  52. Kim C, Gao YT, Xiang YB, Barone-Adesi F, Zhang Y, Hosgood HD, et al. Home kitchen ventilation, cooking fuels, and lung cancer risk in a prospective cohort of never smoking women in Shanghai, China. Int J Cancer 2015;136:632-8.
  53. Peek RM Jr, Mohla S, DuBois RN. Inflammation in the genesis and perpetuation of cancer: summary and recommendations from a national cancer institute-sponsored meeting. Cancer Res 2005;65:8583-6. https://doi.org/10.1158/0008-5472.CAN-05-1777
  54. Brenner DR, Boffetta P, Duell EJ, Bickeboller H, Rosenberger A, McCormack V, et al. Previous lung diseases and lung cancer risk: a pooled analysis from the International Lung Cancer Consortium. Am J Epidemiol 2012;176:573-85. https://doi.org/10.1093/aje/kws151
  55. Denholm R, Schuz J, Straif K, Stucker I, Jockel KH, Brenner DR, et al. Is previous respiratory disease a risk factor for lung cancer? Am J Respir Crit Care Med 2014;190:549-59. https://doi.org/10.1164/rccm.201402-0338OC
  56. Antoniou KM, Tomassetti S, Tsitoura E, Vancheri C. Idiopathic pulmonary fibrosis and lung cancer: a clinical and pathogenesis update. Curr Opin Pulm Med 2015;21:626-33. https://doi.org/10.1097/MCP.0000000000000217
  57. Kwak N, Park CM, Lee J, Park YS, Lee SM, Yim JJ, et al. Lung cancer risk among patients with combined pulmonary fibrosis and emphysema. Respir Med 2014;108:524-30. https://doi.org/10.1016/j.rmed.2013.11.013
  58. Lee T, Park JY, Lee HY, Cho YJ, Yoon HI, Lee JH, et al. Lung cancer in patients with idiopathic pulmonary fibrosis: clinical characteristics and impact on survival. Respir Med 2014;108: 1549-55. https://doi.org/10.1016/j.rmed.2014.07.020
  59. Cancer Genome Atlas Research Network. Comprehensive molecular profiling of lung adenocarcinoma. Nature 2014; 511:543-50. https://doi.org/10.1038/nature13385
  60. Midha A, Dearden S, McCormack R. EGFR mutation incidence in non-small-cell lung cancer of adenocarcinoma histology: a systematic review and global map by ethnicity (mutMapII). Am J Cancer Res 2015;5:2892-911.
  61. Park JY, Jang SH, Kim HJ, Park YB, Kwon JH, Song HH, et al. Predicting the treatment response using a direct sequencing method for EGFR in non-squamous, non-small cell lung cancer. Korean J Med 2011;81:611-22.
  62. Jang TW, Oak CH, Chang HK, Suo SJ, Jung MH. EGFR and KRAS mutations in patients with adenocarcinoma of the lung. Korean J Intern Med 2009;24:48-54. https://doi.org/10.3904/kjim.2009.24.1.48
  63. Kim HJ, Lee KY, Kim YC, Kim KS, Lee SY, Jang TW, et al. Detection and comparison of peptide nucleic acid-mediated real-time polymerase chain reaction clamping and direct gene sequencing for epidermal growth factor receptor mutations in patients with non-small cell lung cancer. Lung Cancer 2012;75:321-5. https://doi.org/10.1016/j.lungcan.2011.08.005
  64. Min KW, Kim WS, Jang SJ, Choi YD, Chang S, Jung SH, et al. Comparison of EGFR mutation detection between the tissue and cytology using direct sequencing, pyrosequencing and peptide nucleic acid clamping in lung adenocarcinoma: Korean multicentre study. QJM 2016;109:167-73. https://doi.org/10.1093/qjmed/hcv103
  65. Sun PL, Seol H, Lee HJ, Yoo SB, Kim H, Xu X, et al. High incidence of EGFR mutations in Korean men smokers with no intratumoral heterogeneity of lung adenocarcinomas: correlation with histologic subtypes, EGFR/TTF-1 expressions, and clinical features. J Thorac Oncol 2012;7:323-30. https://doi.org/10.1097/JTO.0b013e3182381515
  66. Shaw AT, Yeap BY, Mino-Kenudson M, Digumarthy SR, Costa DB, Heist RS, et al. Clinical features and outcome of patients with non-small-cell lung cancer who harbor EML4 -ALK . J Clin Oncol 2009;27:4247-53. https://doi.org/10.1200/JCO.2009.22.6993
  67. Kang HJ, Lim HJ, Park JS, Cho YJ, Yoon HI, Chung JH, et al. Comparison of clinical characteristics between patients with ALK-positive and EGFR-positive lung adenocarcinoma. Respir Med 2014;108:388-94. https://doi.org/10.1016/j.rmed.2013.11.020
  68. Chia PL, Mitchell P, Dobrovic A, John T. Prevalence and natural history of ALK positive non-small-cell lung cancer and the clinical impact of targeted therapy with ALK inhibitors. Clin Epidemiol 2014;6:423-32.
  69. Soda M, Choi YL, Enomoto M, Takada S, Yamashita Y, Ishikawa S, et al. Identification of the transforming EML4-ALK fusion gene in non-small-cell lung cancer. Nature 2007;448:561-6. https://doi.org/10.1038/nature05945
  70. Koivunen JP, Mermel C, Zejnullahu K, Murphy C, Lifshits E, Holmes AJ, et al. EML4-ALK fusion gene and efficacy of an ALK kinase inhibitor in lung cancer. Clin Cancer Res 2008;14: 4275-83. https://doi.org/10.1158/1078-0432.CCR-08-0168
  71. Gainor JF, Shaw AT. Novel targets in non-small cell lung cancer: ROS1 and RET fusions. Oncologist 2013;18:865-75. https://doi.org/10.1634/theoncologist.2013-0095
  72. Yoo SS, Jin G, Jung HJ, Hong MJ, Choi JE, Jeon HS, et al. RET fusion genes in Korean non-small cell lung cancer. J Korean Med Sci 2013;28:1555-8. https://doi.org/10.3346/jkms.2013.28.10.1555
  73. Bae EY, Lee SY, Kang BK, Lee EJ, Choi YY, Kang HG, et al. Replication of results of genome-wide association studies on lung cancer susceptibility loci in a Korean population. Respirology 2012;17:699-706. https://doi.org/10.1111/j.1440-1843.2012.02165.x
  74. Ahn MJ, Won HH, Lee J, Lee ST, Sun JM, Park YH, et al. The 18p11.22 locus is associated with never smoker non-small cell lung cancer susceptibility in Korean populations. Hum Genet 2012;131:365-72. https://doi.org/10.1007/s00439-011-1080-z

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  38. CT features and disease spread patterns in ROS1 -rearranged lung adenocarcinomas: comparison with those of EGFR -mutant or ALK -rearranged lung adenocarcinomas vol.10, pp.1, 2020, https://doi.org/10.1038/s41598-020-73533-y
  39. Lifetime survival and medical costs of lung cancer: a semi-parametric estimation from South Korea vol.20, pp.None, 2016, https://doi.org/10.1186/s12885-020-07353-8
  40. Cancer development in patients with COPD: a retrospective analysis of the National Health Insurance Service-National Sample Cohort in Korea vol.20, pp.1, 2016, https://doi.org/10.1186/s12890-020-01194-8
  41. Serum Reactive Oxygen Species Modulator 1 as a Novel Predictive Biomarker for Resected Lung Adenocarcinoma: A Retrospective Pilot Study vol.14, pp.None, 2021, https://doi.org/10.2147/ott.s336399
  42. Active Treatment Improves Overall Survival in Extremely Older Non–Small Cell Lung Cancer Patients: A Multicenter Retrospective Cohort Study vol.53, pp.1, 2021, https://doi.org/10.4143/crt.2020.894
  43. Excess Mortality of Males Due to Malignant Lung Cancer in OECD Countries vol.18, pp.2, 2016, https://doi.org/10.3390/ijerph18020447
  44. 국가유공자 암환자의 생존율 vol.31, pp.1, 2016, https://doi.org/10.4332/kjhpa.2021.31.1.35
  45. Awareness and Use of Complementary and Alternative Medicine in Korean Lung Cancer Patients vol.84, pp.2, 2021, https://doi.org/10.4046/trd.2020.0098
  46. Recent Trends of Lung Cancer in Korea vol.84, pp.2, 2021, https://doi.org/10.4046/trd.2020.0134
  47. Depressive symptoms among cancer patients: Variation by gender, cancer type, and social engagement vol.44, pp.5, 2016, https://doi.org/10.1002/nur.22168
  48. Impact of idiopathic pulmonary fibrosis on clinical outcomes of lung cancer patients vol.11, pp.1, 2016, https://doi.org/10.1038/s41598-021-87747-1