Korean Journal of Biological Psychiatry (생물정신의학)

The Korean Society of Biological Psychiatry (대한생물정신의학회)
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Role of p11 (S100A10) in Depression and Antidepressant Effects

우울증과 항우울작용에 관한 p11(S100A10)의 역할

  • Park, Sung Woo (Paik Institute for Clinical Research, Inje University College of Medicine) ;
  • Seo, Mi Kyong (Paik Institute for Clinical Research, Inje University College of Medicine) ;
  • Lee, Jung Goo (Paik Institute for Clinical Research, Inje University College of Medicine) ;
  • Kim, Young Hoon (Paik Institute for Clinical Research, Inje University College of Medicine)
  • 박성우 (인제대학교 의과대학 백인제기념임상의학연구소 신경과학연구부) ;
  • 서미경 (인제대학교 의과대학 백인제기념임상의학연구소 신경과학연구부) ;
  • 이정구 (인제대학교 의과대학 백인제기념임상의학연구소 신경과학연구부) ;
  • 김영훈 (인제대학교 의과대학 백인제기념임상의학연구소 신경과학연구부)
  • Received : 2016.01.29
  • Accepted : 2016.02.11
  • Published : 2016.02.29
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Abstract

p11 protein (S100A10) is downregulated in depressive-like states of human and rodent. Antidepressant drug treatment increases p11 levels in rodent models. We reviewed studies demonstrating that p11 levels are regulated in depression and by antidepressant treatment and that p11 upregulation exerts antidepressant effects. Current studies on p11 underscore the importance of p11 as a potential antidepressant target.

Keywords

References

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