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High Performance Materials for Ophthalmic Hydrogel Lens Containing Nanoparticles

  • Kim, Duck-Hyun (Department of Optometry and Vision Science, Catholic University of Daegu) ;
  • Sung, A-Young (Department of Optometry and Vision Science, Catholic University of Daegu)
  • Received : 2016.02.11
  • Accepted : 2016.03.25
  • Published : 2016.03.30

Abstract

The optical and physical and characteristics of hydrogel ophthalmic lens polymerized with addition of 2,6-difluoropyridine, SiPc(silicon 2,9,16,23-tetra-tert-butyl-29H31H-phthalocyanine dihydroxide) and nanodiamond in the basic hydrogel material were evaluated. In particular, the utility of 2,6-difluoropyridine, SiPc and nanodiamond as a hydrogel ophthalmic lens material was investigated. 2,6-difluoropyridine, SiPc and nanodiamond were used as additives. And also, 2-hydroxyethyl methacrylate, acrylic acid, methyl methacrylate and a cross-linker EGDMA were copolymerized in the presence of AIBN as an initiator. The refractive index of 1.4348~1.4361, water content of 33.30~34.02%, UV-B transmittance of 4.77~67.50%, UV-A transmittance of 1.45~89.19% and visible transmittance of 32.12~92.21% were obtained. The results of hydrogel lens containing 2,6-difluoropyridine (add 5%) showed antibiosis for staphylococcus aureus. The produced copolymer is suitable for hydrogel soft ophthalmic lenses with antibiotic and anti-UV effect.

Keywords

References

  1. T.-H. Kim and A.-Y. Sung, "Copolymerization and contact lens application of HEMA-substituted polyphosphazene", Journal of the Korean Chemical Society, Vol. 53, pp. 340-344, 2009. https://doi.org/10.5012/jkcs.2009.53.3.340
  2. G. D. Winter, "Heterotopic bone formation in a synthetic sponge", Proceedings of the Royal Society of Medicine, Vol. 62, pp. 1111-1115, 1970.
  3. M. Tollar, M. Stol, and K. Kliment, "Surgical suture materials coated with a layer of hydrophilic Hydron gel", J. Biomed. Mater. Res. A, Vol. 3, pp. 305-313, 1969. https://doi.org/10.1002/jbm.820030210
  4. M. Baravic, K. Kliment, and M. Zavadil, "Iologic properties and possible uses of polymer-like sponges", J. Biomed. Mater. Res. A, Vol. 1, pp. 313-323, 1967. https://doi.org/10.1002/jbm.820010303
  5. G. Bittner, "Blut in vitro unter der Einwirkung eines elektrischen Stromes", Biomed. Eng-Biomed. Te., Vol. 4, pp. 61-63, 1959. https://doi.org/10.1515/bmte.1959.4.3.61
  6. M. F. Refojo, "A critical review of properties and applications of soft hydrogel contact lenses", Surv. Ophthalmol., Vol. 16, pp. 233-246, 1972.
  7. L. Krejci and H. Krejcova, "Effect of conventional hard and hydrophilic soft contact lenses on the corneal epithelium. Comparative study in tissue culture", Brit. J. Ophthalmol., Vol. 57, pp. 675-680, 1973. https://doi.org/10.1136/bjo.57.9.675
  8. D. H. Kim and A. Y. Sung, "Application of hydroxy-substituted benzophenone group for UV-block soft contact lens", The Korean Journal of Vision Science, Vol. 17, pp. 57-68, 2015.
  9. M. J. Lee, A. Y. Sung, and T. H. Kim, "Influence of wetting agents on physical properties of soft contact lens", The Korean Ophthalmic Optics Society, Vol. 19, pp. 43-49, 2014. https://doi.org/10.14479/jkoos.2014.19.1.43
  10. D. H. Kim, T. H. Kim, and A. Y. Sung, "Ophthalmic application of polymer with high oxygen transmissibility containing 2-(trimethylsilyloxy)ethyl methacrylate", Journal of the Korean Chemical Society, Vol. 57, pp. 405-410, 2013. https://doi.org/10.5012/jkcs.2013.57.3.405
  11. D. H. Kim, A. Y. Sung and T. H. Kim, "Antibacterial and characterization of high performance soft contact lens using fluoro- and carboxy-substituted pyridine as additive", The Korean Journal of Vision Science, Vol. 16, No. 1, pp. 89-97, 2014.
  12. S. W. Kim, M. Adhikari, D. R. Yadav, H. G. Lee, Y. H. Um, H. S. Kim, and Y. S. Lee, "Antimicrobial activity of nano materials against acidovorax citrulli and other plant pathogens", Research in Plant Disease, Vol. 21, pp. 12-19, 2015. https://doi.org/10.5423/RPD.2015.21.1.012
  13. B. H. Lessard, J. D. Dang, T. M. Grant, D. Gao, D. S. Seferos, and T. P. Bender, "Bis(tri-n-hexylsilyl oxide) silicon phthalocyanine: A unique additive in ternary bulk heterojunction organic photovoltaic devices", ACS Appl. Mater. Inter., Vol. 6, pp. 15040-15051, 2014. https://doi.org/10.1021/am503038t
  14. A. Y. Sung and T. H. Kim, "High functional nano materials for ophthalmic lenses containing silicon 2,3-naphthalocyanine bis(trihexylsilyloxide) and silicon 2,9,16,23-tetra-tert-butyl-29H31H-phthalocyanine dihydroxide", J. Nanosci. Nanotechno., Vol. 14, pp. 8523-8530, 2014. https://doi.org/10.1166/jnn.2014.9941
  15. Y. Xing and L. Dai, "Nanodiamonds for nanomedicine", Future Medicine, Vol. 4, pp. 207-218, 2009.
  16. Q. Zou, Y. G. Li, L. H. Zou, and M. Z. Wang, "Characterization of structures and surface states of the nanodiamond synthesized by detonation", Mater. Charact., Vol. 60, pp. 1257-1262, 2009. https://doi.org/10.1016/j.matchar.2009.05.008
  17. T. H. Kim, D. H. Kim, and A. Y. Sung, "Nanodiamond polymer for strength improvement of hydrogel lens with refractive power", Journal of the Korean Chemical Society, Vol. 56, pp. 303-308, 2012. https://doi.org/10.5012/jkcs.2012.56.2.303
  18. S.Y. Park, M. J. Lee, and A. Y. Sung, "Physical and optical properties of hydrophilic tinted lens materials with the fluoro-substituted aniline group", J. Chosun Natural. Sci., Vol. 8, pp. 60-66, 2015. https://doi.org/10.13160/ricns.2015.8.1.60