The Korean Journal of Mycology (한국균학회지)

The Korean Society of Mycology (한국균학회)
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Antihyperglycemic Effect of Water Extracts from Pleurotus cornucopiae-Containing α-Glucosidase Inhibitor

α-Glucosidase 저해물질을 함유한 노랑느타리버섯 (Pleurotus cornucopiae) 물추출물의 혈당상승 억제 효과

  • Shin, Ja-Won (Department of Biomedicinal Science and Biotechnology, Paichai University) ;
  • Bae, Sang-Min (Department of Biomedicinal Science and Biotechnology, Paichai University) ;
  • Han, Sang-Min (Department of Biomedicinal Science and Biotechnology, Paichai University) ;
  • Lee, Yun-Hae (Mushroom Research Station, Gyeonggi-do Agricultural Research & Extension Service) ;
  • Jeong, Youn-Kyung (Mushroom Research Station, Gyeonggi-do Agricultural Research & Extension Service) ;
  • Ji, Jeong-Hyun (Mushroom Research Station, Gyeonggi-do Agricultural Research & Extension Service) ;
  • Lee, Jong-Soo (Department of Biomedicinal Science and Biotechnology, Paichai University)
  • 신자원 (배재대학교 바이오.의생명공학과) ;
  • 배상민 (배재대학교 바이오.의생명공학과) ;
  • 한상민 (배재대학교 바이오.의생명공학과) ;
  • 이윤혜 (경기도농업기술원 버섯연구소) ;
  • 정윤경 (경기도농업기술원 버섯연구소) ;
  • 지정현 (경기도농업기술원 버섯연구소) ;
  • 이종수 (배재대학교 바이오.의생명공학과)
  • Received : 2016.01.18
  • Accepted : 2016.03.09
  • Published : 2016.03.31
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Abstract

Following preparation of water extracts of Pleurotus cornucopiae fruiting body-containing ${\alpha}$-glucosidase inhibitor, their antihyperglycemic effects were examined using streptozotocin-induced diabetic Sprague-Dawley (SD)-rats. The water extracts from Pleurotus cornucopiae showed dosage-dependant antihyperglycemic effects on the streptozotocin-induced diabetic SD-rats after oral administration to 120 min on the short time test and 4 days on the long time test, respectively. The water extracts from Pleurotus cornucopiae fruiting body showed dosage-dependent hypoglycemic action after administration to 120 min and 4 days in the SD-rat and streptozotocin-induced diabetic SD-rat.

식용버섯 자실체를 이용하여 새로운 식후 혈당상승억제물질을 개발하기 위하여 노랑느타리버섯 자실체에 함유되어있는 ${\alpha}$-glucosidase 저해물질을 증류수로 추출하여 식후 혈당 상승억제효과를 조사하였다. ${\alpha}$-Glucosidase 저해물질을 함유한 노랑느타리버섯 물추출물은 streptozotocin으로 당뇨를 유발시킨 당뇨 쥐에서 장기 30 mg/kg, 150 mg/kg 경구투여(2일)와 단기 500 mg/kg, 1,000 mg/kg 경구투여(120분)시 모두, 농도 의존적으로 식후 혈당상승억제 효과를 보였다.

Keywords

References

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