Food Science and Industry (식품과학과 산업)

Korean Society of Food Science and Technology (한국식품과학회)
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Scientific review on safety of monosodium glutamate

글루탐산나트륨(Monosodium glutamate; MSG)의 안전성 이슈에 대한 과학적 고찰

  • Lee, Kwang-Won (Department of Biotechnology, College of Life Science & Biotechnology, Korea University)
  • Published : 2016.03.31
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Abstract

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References

  1. Paracelsus, PG, Defensiones S. Die Selbstverteidigung eines Aussenseiters. Schwabe (2003)
  2. 식품의약품안전처. L-글루타민산나트륨에 대하여. 첨가물기준과, (2010) Available from http://www.mfds.go.kr/index.do?mid=675&seq=11961&cmd=v.
  3. 최낙언. 화학조미료? MSG 유해성 주장은 물의 유해성 주장과 같다. (2013) Available from http://seehint .com/Hint.asp?md=201&no=11157.
  4. 최낙언, 노중섭. 아무도 알려주지 않는 감칠맛과 MSG 이야기. 리북, p34 (2013)
  5. 최낙언. 맛의 원리. 리북. p20 (2015)
  6. 최낙언, 노중섭. 아무도 알려주지 않는 감칠맛과 MSG 이야기. 리북, p41 (2013)
  7. Burrin DG, Stoll B. Metabolic fate and function of dietary glutamate in the gut. Am. J. Clin. Nutr. 90(3): 850-856 (2009) https://doi.org/10.3945/ajcn.2009.27462Y
  8. Windmueller HG, Spaeth AE. Intestinal metabolism of glutamine and glutamate from the lumen as compared to glutamine from blood. Arch. Biochem. Biophys. 171(2): 662-672 (1975) https://doi.org/10.1016/0003-9861(75)90078-8
  9. Lambert BD, Filip R, Stoll B, Junghans P, Derno M, Hennig U, Souffrant WB, Pierzynowski S, Burrin DG. First-pass metabolism limits the intestinal absorption of enteral ${\alpha}$-ketoglutarate in young pigs. J. Nutr. 136(11): 2779-84 (2006) https://doi.org/10.1093/jn/136.11.2779
  10. Lambert BD, Stoll B, Niinikoski H, Pierzynowski S, Burrin DG. Net portal absorption of enterally fed alpha-ketoglutarate is limited in young pigs. J. Nutr. 132(11): 3383-86 (2002) https://doi.org/10.1093/jn/132.11.3383
  11. Falalyeyeva T, Beregova T. Role of peripheral glutamate receptors in regulation of gastric secretion and motor function of stomach. J. Pre-Clin. Clin. Res. 1(2): 107-11 (2007)
  12. Covasa M, Ritter RC, Burns GA. NMDA receptor participation in control of food intake by the stomach. Am. J. Physiol. Regul. Integr. Comp. Physiol. 278(5): R1362-R1368 (2000) https://doi.org/10.1152/ajpregu.2000.278.5.R1362
  13. Sengupta J, Petersen J, Peles S, Shaker R. Response properties of antral mechanosensitive afferent fibers and effects of ionotropic glutamate receptor antagonists. Neuroscience, 125(3): 711-723 (2004) https://doi.org/10.1016/j.neuroscience.2004.02.018
  14. Kondoh T, Mallick HN, Torii K. Activation of the gut-brain axis by dietary glutamate and physiologic significance in energy homeostasis. Am. J. Clin. Nutr. 90(3): 832-37 (2009) https://doi.org/10.3945/ajcn.2009.27462V
  15. Hara S, Shibuya T, Nakakawaji K, Kyu M, Nakamura Y, Hoshikawa H, Takeuchi T, Iwao T, Ino H. Observations of pharmacological actions and toxicity of sodium glutamate, with comparisons between natural and synthetic products. J. Tokyo. Med. Coll., 20(1), 69-100 (1962)
  16. FAO Nutrition Meetings. The result of the deliberations of the Joint FAO/WHO Expert Committee on Food Additives which met in Geneva. Report Series No. 48A (1970)
  17. Daniel RG, Waisman HA. The effects of excess amino acids on the growth of the young rat. Growth, 32(4): 255-65 (1968)
  18. Little, AD. Report to International Mineral & Chemical Corporation dated (1953a)
  19. Little AD. Report to International Mineral & Chemical Corporation dated (1953b)
  20. Shibata MA. Tanaka H, Kawabe M, Sano M, Hagiwara A, Shirai T. Lack of carcinogenicity of monosodium L-glutamate in Fischer 344 rats. Food Chem. Toxicol. 33(5): 383-91 (1995) https://doi.org/10.1016/0278-6915(94)00152-E
  21. Yonetani S, Unpublished report of Central Research Laboratories, Ajinomoto Co., Inc. (1967)
  22. Khera KS, Whitta LL, Nera EA. Unpublished result of Research Lab., Food & Drug Directorate, Ottawa, Canada (1970)
  23. Suzuki Y, Takahashi M. Unpublished report to Ajinomoto Co. Inc. (1970)
  24. Schaumburg HH, Byck R, Gerstl R, Mashman JH. Monosodium L-glutamate: its pharmacology and role in the Chinese restaurant syndrome. Science, 163(3689): 826-8 (1969) https://doi.org/10.1126/science.163.3869.826
  25. Ichimura M, Tanaka M, Tomita K, Kirimura J, Ishizaki T. Unpublished report of Central Research Laboratories, Ajinomoto Co., Inc. (1970b)
  26. Olney JW. Brain lesions, obesity, and other disturbances in mice treated with monosodium glutamate. Science, 164(3880): 719-21 (1969) https://doi.org/10.1126/science.164.3880.719
  27. Fuke S, Shimizu, T. Sensory and preference aspects of umami. Trends Food Sci. Tech. 4(8): 246-251 (1993) https://doi.org/10.1016/0924-2244(93)90139-2
  28. Meldrum B. Amino acids as dietary excitotoxins: a contribution to under standing neurodegenerative disorders. Brain Res. Rev. 18(3): 293-314 (1993) https://doi.org/10.1016/0165-0173(93)90014-Q
  29. Bazzano G, D'Elia JA, Olson, RE. Monosodium glutamate: feeding of large amounts in man and gerbils. Science, 169(3951): 1208-9 (1970) https://doi.org/10.1126/science.169.3951.1208
  30. Pardridge WM. Regulation of amino acid availability to brain: selective control mechanisms for glutamate. Glutamic Acid. Adv. Biochem. Physiol. 125-137 (1979)
  31. Meldrum BS. Glutamate as a neurotransmitter in the brain: review of physiology and pathology. J. Nutr. 130(4): 1007-15 (2000) https://doi.org/10.1093/jn/130.4.1007S
  32. Fernstrom JD. Dietary amino acids and brain function. J. Am. Diet. Assoc. 94(1): 71-77 (1994) https://doi.org/10.1016/0002-8223(94)92045-1
  33. Parker SL, Krondl M, Coleman P. Foods perceived by adults as causing adverse reactions. J. Am. Diet. Assoc. 93(1): 40-44 (1993) https://doi.org/10.1016/0002-8223(93)92128-K
  34. FDA. Questions and Answers on Monosodium glutamate (MSG), (2012). Available from:www.fda.gov/food/ingredientspackaginglabeling/ foodadditives ingredients/ucm328728.htm
  35. Commision of the European Communities. Reports of the Scientific Committee for Food, 1990
  36. Walker R, Lupien JR. The safety evaluation of monosodium glutamate. J. Nutr. 130(4): 1049-52 (2000) https://doi.org/10.1093/jn/130.4.1049S
  37. Health canada. Questions and Answers on Monosodium glutamate(MSG) (2008). Available from: http://www.hc-sc.gc.ca/fn-an/securit/addit/msg_qa-qr-eng.php,
  38. FSANZ. Mandatory declaration of monosodium glutamte by restaurants and other food outlets. (2002)
  39. 최낙언. MSG 안전하다-식품의약품안전청. (2010). Available from http://WWW.seehint.com/hint.asp?md=201&no=11128,