Journal of Preventive Medicine and Public Health

  • 제49권1호
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  • Pages.45-52
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  • 2016
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  • 1975-8375(pISSN)
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  • 2233-4521(eISSN)
대한예방의학회 (The Korean Society for Preventive Medicine)
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Diabetes Mellitus and Site-specific Colorectal Cancer Risk in Korea: A Case-control Study

  • Woo, Hyeongtaek (Department of Preventive Medicine, Seoul National University College of Medicine) ;
  • Lee, Jeeyoo (Department of Preventive Medicine, Seoul National University College of Medicine) ;
  • Lee, Jeonghee (Molecular Epidemiology Branch, Division of Cancer Epidemiology and Prevention, Research Institute, National Cancer Center) ;
  • Park, Ji Won (Center for Colorectal Cancer, Research Institute and Hospital, National Cancer Center) ;
  • Park, Sungchan (Center for Colorectal Cancer, Research Institute and Hospital, National Cancer Center) ;
  • Kim, Jeongseon (Molecular Epidemiology Branch, Division of Cancer Epidemiology and Prevention, Research Institute, National Cancer Center) ;
  • Oh, Jae Hwan (Center for Colorectal Cancer, Research Institute and Hospital, National Cancer Center) ;
  • Shin, Aesun (Department of Preventive Medicine, Seoul National University College of Medicine)
  • 투고 : 2015.04.30
  • 심사 : 2015.12.22
  • 발행 : 2016.01.31
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초록

Objectives: Previous large-scale cohort studies conducted in Korea have found a positive association between diabetes mellitus (DM) and colorectal cancer (CRC) in men only, in contrast to studies of other populations that have found significant associations in both men and women. Methods: A total of 1070 CRC cases and 2775 controls were recruited from the National Cancer Center, Korea between August 2010 and June 2013. Self-reported DM history and the duration of DM were compared between cases and controls. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated by binary and polytomous logistic regression models. Results: DM was associated with an elevated risk of CRC in both men (OR, 1.47; 95% CI, 1.13 to 1.90) and women (OR, 1.92; 95% CI, 1.24 to 2.98). This association remained when we controlled for age, body mass index, alcohol consumption, and physical activity level. In sub-site analyses, DM was associated with distal colon cancer risk in both men (multivariate OR, 2.04; 95% CI, 1.39 to 3.00) and women (multivariate ORs, 1.99; 95% CI, 1.05 to 3.79), while DM was only associated with rectal cancer risk in women (multivariate OR, 2.05; 95% CI, 1.10 to 3.82). No significant association was found between DM and proximal colon cancer risk in either men (multivariate OR, 1.45; 95% CI, 0.88 to 2.41) or women (multivariate OR, 1.79; 95% CI, 0.78 to 4.08). Conclusions: Overall, DM was associated with an increased risk of CRC in Koreans. However, potential over-estimation of the ORs should be considered due to potential biases from the case-control design.

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