Journal of the Institute of Electronics and Information Engineers (전자공학회논문지)

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Optimization of Flip Angle at Head & Neck MR Angiography using Gadoteridol

Gadoteridol을 이용한 Head & Neck MR Angiography에서의 적정 Flip Angle

  • Jeong, Hyunkeun (Medical Imaging of Engineering, Korea University) ;
  • Kim, Mingi (Electronics&Information Engineering, Korea University) ;
  • Song, Jaejun (Otolaryngology, Korea University Guro Hospital) ;
  • Nam, Kichang (Medical Engineering, Dongguk University College of Medicine) ;
  • Choi, Hyunsung (Biology science, University of Texas at Dallas) ;
  • Jeong, Hyundo (Department of Psychology, Templeton University) ;
  • Kim, Hochul (Department of Radiological Science, Eulji University)
  • 정현근 (고려대학교 의용과학대학원 의료영상공학과) ;
  • 김민기 (고려대학교 전자 정보공학과) ;
  • 송재준 (고려대학교 구로병원 이비인후과) ;
  • 남기창 (동국대학교 의과대학 의공학교실) ;
  • 최현성 (텍사스 주립대학교 분자세포생물학과) ;
  • 정현도 (템플턴대학교 심리학과) ;
  • 김호철 (을지대학교 방사선학과)
  • Received : 2016.01.08
  • Accepted : 2016.03.01
  • Published : 2016.03.25
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Abstract

In this research, we tried to suggest moderate FA(Flip Angle) for CE(Contrast Enhnaced)-Head&Neck MR Angiography with Gadoteridol. For this study, we did test MR phantom and clinical study according to FA change. After that, quantitative analysis was progressed. The results of MR phantom study were as follow: RSP(Reaction Starting Point)was recorded within 300~400 mmol. MPSI(Max Peak Signal Intensity) was 2,086, 3,705, 5,109, 6,194, 7.096, 7,192 [a.u]. MPP(Max Peak Point) was shown at 30, 50, 50, 40, 50, 40 mmol. IRMPSI(Increase Rate of MPSI) was 77.6%, 37.9%, 21.2%, 14.6%, 1.4% as increasing of FA. The results of clinical study were as follow SICB(Signal Intensity of Carotid artery Bifurcation) was recorded respectively 392.5, 4165.2, 4270, 3502.2, 3263.7, 3119.6 [a.u]. ORA(Occurence Rate of Artifact) was increased as 0, 0, 20, 40, 50, 70%. According to this research, we are not only able to assure that increase of FA can be effect on H1 spin's SI(Signal Intensity) which was combined with gadolinium agent, but also be effect on artifact rate in blood vessel. In clinical field, we expect that CE-Head&Neck MR Angiography can be performed in a practical way with this research.

본 연구의 목적은 가돌리늄 조영제를 사용한 Head & Neck MR Angio검사에 있어서 매개변수인 FA(Flip Angle)이 MR신호에 미치는 영향에 대해서 알아보고자 하였으며, 이에 따른 FA의 적정 값을 제시하는 것이다. 실험은 FA증가에 따른 MR팬텀실험과 임상실험으로 진행하였고, 이에 대한 정량적 분석이 이루어졌다. 실험결과 팬텀실험에서의 조영증강 반응시작 지점인 RSP(Reaction Starting Point)는 FA증가에 따라 300~400 mmol 사이에서 반응하였고, 최대 신호강도인 MPSI(Max Peak Signal Intensity)는 2,086, 3,705, 5,109, 6,194, 7.096, 7,192 [a.u]를 기록하였다. MPSI가 형성되는 몰농도 지점인 MPP(Max Peak Point)는 FA에 증가에 따라 40, 50, 50, 40, 50, 40 mmol에서 보였으며, MPSI의 증가율인 IRMPSI(Increase Rate of MPSI)는 77.6%, 37.9%, 21.2%, 14.6%, 1.4%임을 확인하였다. 임상실험에서의 평가기준인 SICB(Signal Intensity of Carotid artery Bifurcation)는 FA증가에 따라 각 평균값 2392.5, 4165.2, 4270, 3502.2, 3263.7, 3119.6 [a.u]를 기록하였고, 아티팩트 발생율인 ORA(Occurence Rate of Artifact)는 0, 0, 20, 40, 50, 70%로 점차 증가하였다. 본 연구를 통하여 FA의 증가는 혈관 내 가돌리늄과 결합한 H1스핀의 신호강도와 아티팩트에 영향을 미친다는 사실을 확인하였고, 이는 실제 임상에서의 CE(Contrast Enhanced)-Head&Neck MR Angio검사에 있어서 본 연구의 데이터를 활용한다면 진단학적으로 효율적인 MR Angiography 영상을 구현할 수 있을 것으로 사료된다.

Keywords

References

  1. HK. Jeong, H. Jung, and H. Kim, "Quantitative Analysis of GBCA Reaction by Mol Concentration Change on MRI Sequence", The Institute of Electronics and Information Engineers, vol.52, No.2, pp.182-192, Feb, 2015. https://doi.org/10.5573/ieie.2015.52.2.182
  2. HK. Jeong, H. Jung, K. Nam and H. Kim, "Gadoteridol's Signal Change according to TR, TE Parameters in T1 Image", The Institute of Electronics and Information Engineers, vol.52, No.9, pp.117-124, Sep, 2015.
  3. HK. Jeong, H. Jung, K. Nam, G. Jang and H. Kim, "Comparative Analysis of Quantitative Signal Intensity between 1.0 mol and 0.5 mol MR Contrast Agent", The Institute of Electronics and Information Engineers, vol.52, No.12, pp.134-141, Dec, 2015. https://doi.org/10.5573/ieie.2015.52.12.134
  4. E. Hagberg, and K. Scheffler, "Effect of r(1) and r(2) relaxivity of gadolinium-based contrast agents on the T(1)-weighted MR signal at increasing magnetic field strengths", ContrastMedia MolImaging, vol.8 no.6, pp.456-65, Nov-Dec, 2013.
  5. Z. Seidl, J. Vymazal, M. Mechl, M. Goyal, M. Herman, C. Colosimo, M. Pasowicz, R. Yeung, B. Paraniak-Gieszczyk, B. Yemen, N. Anzalone, A. Citterio, G. Schneider, S. Bastianello, and J. Ruscalleda, "Does higher gadolinium concentration play a role in the morphologic assessment of brain tumors? Results of a multicenter intraindividual crossover comparison of gadobutrol versus gadobenate dimeglumine(the MERIT Study)", AJNRAmJNeuroradiol, vol.33, no.6, pp.1050-8, Jun, 2012.
  6. H. S. Thomsen, S. K. Morcos, T. Almen, M. F. Bellin, M. Bertolotto, G. Bongartz, O. Clement, P. Leander, G. Heinz-Peer, P. Reimer, F. Stacul, A. van der Molen, J. A. Webb, and E. C. M. S. Committee, "Nephrogenic systemic fibrosis and gadolinium-based contrast media: updated ESUR Contrast Medium Safety Committee guidelines", EurRadiol, vol.23, no.2, pp.307-18, Feb, 2013.
  7. F. G. Shellock, and A. Spinazzi, "MRI safety update 2008: part 1, MRI contrast agents and nephrogenic systemic fibrosis", AJRAm JRoentgenol, vol.191, no.4, pp.1129-39, Oct, 2008.
  8. M. J. Sharafuddin, A. H. Stolpen, S. Sun, C. R. Leusner, A. A. Safvi, J. J. Hoballah, W. J. Sharp, and J. D. Corson, "High-resolution multiphase contrast-enhanced three- dimensional MR angiography compared with two-dimensional time-of-flight MR angiography for the identification of pedal vessels," JVascInterv Radiol, vol.13, no.7, pp.695-702, Jul, 2002.