Korean Journal of Biological Psychiatry (생물정신의학)

The Korean Society of Biological Psychiatry (대한생물정신의학회)
권호 표지

Correlation between Quantitative Electroencephalogram Findings and Neurocognitive Functions in Patients with Obsessive-Compulsive Disorder and Schizophrenia

강박장애 및 조현병 환자에서의 정량뇌파 소견과 신경인지기능 간의 연관성

  • Kim, Seoyoung (Department of Psychiatry, Seoul National University Hospital) ;
  • Shin, Jung Eun (Department of Psychiatry, Seoul National University Hospital) ;
  • Kim, Min Joo (Department of Psychiatry, Seoul National University Hospital) ;
  • Kwon, Jun Soo (Department of Psychiatry, Seoul National University Hospital) ;
  • Choi, Soo-Hee (Department of Psychiatry, Seoul National University Hospital)
  • 김서영 (서울대학교병원 정신건강의학과) ;
  • 신정은 (서울대학교병원 정신건강의학과) ;
  • 김민주 (서울대학교병원 정신건강의학과) ;
  • 권준수 (서울대학교병원 정신건강의학과) ;
  • 최수희 (서울대학교병원 정신건강의학과)
  • Received : 2016.08.31
  • Accepted : 2016.10.04
  • Published : 2016.11.30
Download PDF
⟨ Previous Next ⟩

Abstract

Objectives Obsessive-compulsive disorder (OCD) and schizophrenia have many common clinical and neurocognitive features. However, not all of them share the same underlying mechanism. The aim of this study was to discover evidences that indicate a pathophysiological mechanism specific to OCD by comparing correlations of quantitative electroencephalography (QEEG) patterns and neurocognitive function in patients with OCD and schizophrenia. Methods Resting-state QEEG data of total 265 patients were acquired retrospectively and parameters such as absolute power, relative power and peak frequency were analyzed from the data. Stroop test and Trail Making Test results as well as demographic features were reviewed for this study. The correlation of neurocognitive functions and brain electrical activities in each group were assessed and compared by correlation analysis. Results Compared with the OCD group, the schizophrenia group performed poorly in neurocognitive tests. Mean values of QEEG parameters in patients with OCD and schizophrenia did not show significant differences. Both absolute and relative power of alpha rhythm in central and frontal regions showed significant positive correlation with Stroop test results in OCD patients. Conclusions Findings in this study shows distinctive correlations between frontal executive dysfunction and frontal alpha rhythm in the OCD patients, both of which might be a candidate for endophenotype underlying obsessive rumination.

Keywords

References

  1. Bottas A, Cooke RG, Richter MA. Comorbidity and pathophysiology of obsessive-compulsive disorder in schizophrenia: is there evidence for a schizo-obsessive subtype of schizophrenia? J Psychiatry Neurosci 2005;30:187-193.
  2. Kim MS, Kang SS, Youn T, Kang DH, Kim JJ, Kwon JS. Neuropsychological correlates of P300 abnormalities in patients with schizophrenia and obsessive-compulsive disorder. Psychiatry Res 2003;123:109-123. https://doi.org/10.1016/S0925-4927(03)00045-3
  3. Kwon JS, Shin YW, Kim CW, Kim YI, Youn T, Han MH, et al. Similarity and disparity of obsessive-compulsive disorder and schizophrenia in MR volumetric abnormalities of the hippocampus-amygdala complex. J Neurol Neurosurg Psychiatry 2003;74:962-964. https://doi.org/10.1136/jnnp.74.7.962
  4. Tumkaya S, Karadag F, Oguzhanoglu NK, Tekkanat C, Varma G, Ozdel O, et al. Schizophrenia with obsessive-compulsive disorder and obsessive-compulsive disorder with poor insight: a neuropsychological comparison. Psychiatry Res 2009;165:38-46. https://doi.org/10.1016/j.psychres.2007.07.031
  5. Roh KS, Shin MS, Kim MS, Ha TH, Shin YW, Lee KJ, et al. Persistent cognitive dysfunction in patients with obsessive-compulsive disorder: a naturalistic study. Psychiatry Clin Neurosci 2005;59:539-545. https://doi.org/10.1111/j.1440-1819.2005.01411.x
  6. de Geus F, Denys DA, Sitskoorn MM, Westenberg HG. Attention and cognition in patients with obsessive-compulsive disorder. Psychiatry Clin Neurosci 2007;61:45-53. https://doi.org/10.1111/j.1440-1819.2007.01609.x
  7. Bannon S, Gonsalvez CJ, Croft RJ, Boyce PM. Executive functions in obsessive-compulsive disorder: state or trait deficits? Aust N Z J Psychiatry 2006;40:1031-1038.
  8. Ekerholm M, Firus Waltersson S, Fagerberg T, Soderman E, Terenius L, Agartz I, et al. Neurocognitive function in long-term treated schizophrenia: a five-year follow-up study. Psychiatry Res 2012;200:144-152. https://doi.org/10.1016/j.psychres.2012.05.008
  9. Martin V, Huber M, Rief W, Exner C. Comparative cognitive profiles of obsessive-compulsive disorder and schizophrenia. Arch Clin Neuropsychol 2008;23:487-500. https://doi.org/10.1016/j.acn.2008.03.006
  10. Shin NY, Lee TY, Kim E, Kwon JS. Cognitive functioning in obsessive-compulsive disorder: a meta-analysis. Psychol Med 2014;44:1121-1130. https://doi.org/10.1017/S0033291713001803
  11. Youn T, Kwon JS. Clinical Applications of Quantitative EEG. Sleep Med Psychophysiol 1995;2:31-43.
  12. Karadag F, Oguzhanoglu NK, Kurt T, Oguzhanoglu A, Atesci F, Ozdel O. Quantitative EEG analysis in obsessive compulsive disorder. Int J Neurosci 2003;113:833-847. https://doi.org/10.1080/00207450390200963
  13. Pogarell O, Juckel G, Mavrogiorgou P, Mulert C, Folkerts M, Hauke W, et al. Symptom-specific EEG power correlations in patients with obsessive-compulsive disorder. Int J Psychophysiol 2006;62:87-92. https://doi.org/10.1016/j.ijpsycho.2006.02.002
  14. Bucci P, Mucci A, Volpe U, Merlotti E, Galderisi S, Maj M. Executive hypercontrol in obsessive-compulsive disorder: electrophysiological and neuropsychological indices. Clin Neurophysiol 2004;115:1340-1348. https://doi.org/10.1016/j.clinph.2003.12.031
  15. Zielinska J, Goral-Polrola J, Polrola P, Luckos M, Kropotov JD, Pachalska M. Hyper-frontality in an OCD patient-evidence from event-related potentials in a cued GO/NOGO task. Ann Agric Environ Med 2016;23:276-279. https://doi.org/10.5604/12321966.1203890
  16. Ranlund S, Nottage J, Shaikh M, Dutt A, Constante M, Walshe M, et al. Resting EEG in psychosis and at-risk populations--a possible endophenotype? Schizophr Res 2014;153:96-102. https://doi.org/10.1016/j.schres.2013.12.017
  17. Kam JW, Bolbecker AR, O'Donnell BF, Hetrick WP, Brenner CA. Resting state EEG power and coherence abnormalities in bipolar disorder and schizophrenia. J Psychiatr Res 2013;47:1893-1901. https://doi.org/10.1016/j.jpsychires.2013.09.009
  18. Bazanova OM, Vernon D. Interpreting EEG alpha activity. Neurosci Biobehav Rev 2014;44:94-110. https://doi.org/10.1016/j.neubiorev.2013.05.007
  19. Son KL, Choi JS, Lee J, Park SM, Lim JA, Lee JY, et al. Neurophysiological features of Internet gaming disorder and alcohol use disorder: a resting-state EEG study. Transl Psychiatry 2015;5:e628. https://doi.org/10.1038/tp.2015.124
  20. Schirmbeck F, Rausch F, Englisch S, Eifler S, Esslinger C, Meyer-Lindenberg A, et al. Stable cognitive deficits in schizophrenia patients with comorbid obsessive-compulsive symptoms: a 12-month longitudinal study. Schizophr Bull 2013;39:1261-1271. https://doi.org/10.1093/schbul/sbs123
  21. Lysaker PH, Lancaster RS, Nees MA, Davis LW. Patterns of obsessive-compulsive symptoms and social function in schizophrenia. Psychiatry Res 2004;125:139-146. https://doi.org/10.1016/j.psychres.2003.12.007
  22. Michalopoulou PG, Konstantakopoulos G, Typaldou M, Papageorgiou C, Christodoulou GN, Lykouras L, et al. Can cognitive deficits differentiate between schizophrenia with and without obsessivecompulsive symptoms? Compr Psychiatry 2014;55:1015-1021. https://doi.org/10.1016/j.comppsych.2013.12.004
  23. Cunill R, Huerta-Ramos E, Castells X. The effect of obsessive-compulsive symptomatology on executive functions in schizophrenia: a systematic review and meta-analysis. Psychiatry Res 2013;210:21-28. https://doi.org/10.1016/j.psychres.2013.05.029
  24. Harsanyi A, Csigo K, Rajkai C, Demeter G, Nemeth A, Racsmany M. Two types of impairments in OCD: obsessions, as problems of thought suppression; compulsions, as behavioral-executive impairment. Psychiatry Res 2014;215:651-658. https://doi.org/10.1016/j.psychres.2013.11.014
  25. West R, Bell MA. Stroop color-word interference and electroencephalogram activation: evidence for age-related decline of the anterior attention system. Neuropsychology 1997;11:421-427. https://doi.org/10.1037/0894-4105.11.3.421
  26. Fan Y, Tang YY, Tang R, Posner MI. Short term integrative meditation improves resting alpha activity and stroop performance. Appl Psychophysiol Biofeedback 2014;39:213-217. https://doi.org/10.1007/s10484-014-9258-5
  27. Schiller B, Gianotti LR, Nash K, Knoch D. Individual differences in inhibitory control--relationship between baseline activation in lateral PFC and an electrophysiological index of response inhibition. Cereb Cortex 2014;24:2430-2435. https://doi.org/10.1093/cercor/bht095