DOI QR코드

DOI QR Code

통계자료를 통한 국내 성조숙증 진료현황 분석

An Increase of Patients Diagnosed as Precocious Puberty among Korean Children from 2010 to 2015

  • 투고 : 2016.10.28
  • 심사 : 2016.11.17
  • 발행 : 2016.11.30

초록

Objectives The purpose of this study is to emphasize the importance of preventing precocious puberty. This study assessed current number of the patients with early puberty and their medical expenses from 2010 to 2015. Methods Using the data from Korean Statistical Information Service and Heathcare Bigdata Hub, number of patients diagnosed with precocious puberty by gender, age, and year from 2010 to 2015 were reviewed. Also, annual medical insurance expenses and the incidence of leuprorelin use were reviewed. Results Number of the patients with precocious puberty has increased from 29,251 in 2010 to 75,945 in 2015. Total medical insurance expenses have increased from 25,716,431 won in 2010 to 56,367,981 won in 2015. The use of lueprorelin also has increased annually from 11,097,590,000 won in 2010 to 21,617,585,000 won in 2015. Conclusions As a result, the patients diagnosed with precocious puberty are increasing in number, and their medical costs have been rising as well. It may be necessary to control the environmental causes of precocious puberty to reduce not only the physical and psychosocial health problems, but also the social costs.

키워드

참고문헌

  1. Shirtcliff EA, Dahl RE, Pollak SD. Pubertal development: correspondence between hormonal and physical development. Child Dev. 2009;80:327-37. https://doi.org/10.1111/j.1467-8624.2009.01263.x
  2. Brook CGD, Clyton PE, Brown TS, Savage MO. Brook's clinical pediatric endocrinology. 5th ed. Blackwell Publishing Co. 2005:183-210.
  3. Ora HP, Emily CW. When puberty is precocious: scientific and clinical aspects. Humana Press. 2007:105-36.
  4. Park MJ, Lee IS, Shin EK, Joung HJ, Cho SI. The timing of sexual maturation and secular trends of menarchial age in Korean adolescents. Korean J Pediatr. 2006;49:610-6. https://doi.org/10.3345/kjp.2006.49.6.610
  5. Park YJ, Moon CM, Yoo HJ. A study of factors influencing advanced puberty. Korean J Pediatr. 2010;53:146-51. https://doi.org/10.3345/kjp.2010.53.2.146
  6. Korean Statistical Information Service. Population projection. http://kosis.kr/statisticsList/statisticsList_01List.jsp?vwcd=MT_ZTITLE&parmTabId=M_01_01#SubCont.
  7. Heathcare Bigdata Hub. Statistics by Four-character subcategories. http://opendata.hira.or.kr/op/opcolap4thDsInfo.do.
  8. Heathcare Bigdata Hub. Statistics by ATC codes (by year, gender, age). http://opendata.hira.or.kr/op/opc/olapMsupTrdInfo.do.
  9. Mayo clinic. Precocious puberty. http://www.mayoclinic.org/diseases-conditions/precocious-puberty/basics/definition/con-20029745.
  10. Kim EK, Sung WY, Song KS. Study on Chungye relevant to menstration starting and pause compared by oriental and western Medicine. J Korean med. 1996;17(2):48-57.
  11. Ahn JE, Kang JS. Study on Tiangui - according to successive physicians. J Oriental Physiol. 1999;14(2):139-48.
  12. Jeon MH, Park JS, Kim DC. A study on the cycle of Tiangui and circadian-rhythms -by the relation of bioclock theory and hormone. J East West Med. 2009;34(3):47-54.
  13. Lee DW, Ku SG, Yang CH, Jang EY, Choi SH. Biology of gonadotropin-releasing hormone, GnRH. J East West Med. 2010;35(1):27-36.
  14. Lee MJ, Chang GT, Han YJ. The study for precocious puberty in recent journals of traditional Chinese medicine. J Korean Orient Pediatr. 2008;22(1):163-87.
  15. Hong CH, Gho HR, Park GS. The secular trend of menarchial age in Korea. J Korean Pediatr Soc. 1993;36:239-43.
  16. Kim SH, Huh K, Won SH, Lee KW, Park MJ. A significant increase in the incidence of central precocious puberty among Korean girls from 2004 to 2010. Plos One. 2015;10(11):e0141844. https://doi.org/10.1371/journal.pone.0141844
  17. Park MJ. Update in the etiology and treatment of sexual precocity. Korean J Pediatr. 2006;49:718-25. https://doi.org/10.3345/kjp.2006.49.7.718
  18. Lim JS, Lee HS, Kim EY, Yi KH, Hwang JS. Early menarche increases the risk of type 2 diabetes in young and middle-aged Korean women. Diabet Med. 2015;32:521-5. https://doi.org/10.1111/dme.12653
  19. Baek TH, Lim NK, Kim MJ, Lee JW, Ryu SH, Chang YS, Choi Y, Park HY. Age at menarche and its association with dysglycemia in Korean middle-aged women. Menopause. 2015;22:542-8. https://doi.org/10.1097/GME.0000000000000353
  20. Lakshman R, Forouhi NG, Sharp SJ, Luben R, Bingham SA, Khaw KT, Wareham NJ, Ong KK. Early age at menarche associated with cardiovascular disease and mortality. J Clin Endocrinol Metab. 2009;94:4953-60. https://doi.org/10.1210/jc.2009-1789
  21. Kotsopoulos J, Lubinski J, Lynch HT, Neuhausen SL, Ghadirian P, Isaacs C, Weber B, Sing CK, Foulkes WD, Baruch RG, Ainsworth P, Friedman E, Daly M, Garber JE, Karlan B, Olopade OI, Tung N, Saal HM, Eisen A, Osborne M, Olsson H, Gilchrist D, Sun P, Narod SA. Age at menarche and the risk of breast cancer in BRCA1 and BRCA2 mutation carriers. Cancer Causes Control. 2005;16:667-74. https://doi.org/10.1007/s10552-005-1724-1
  22. Collaborative Group on Hormonal Factors in Breast Cancer. Menarche, menopause, and breast cancer risk: individual participant meta-analysis, including 118 964 women with breast cancer from 117 epidemiological studies. Lancet Oncol. 2012;13:1141-51. https://doi.org/10.1016/S1470-2045(12)70425-4
  23. Gong TT, Wang YL, Ma XX. Age at menarche and endometrial cancer risk: a dose-response meta-analysis of prospective studies. Sci Rep. 2015;5:14051. https://doi.org/10.1038/srep14051
  24. Yoo JH. Effect of early menarche on physical and psycosocial health problems in adolescent girls and adult women. Korean J Pediatr. 2016;59(9):355-61. https://doi.org/10.3345/kjp.2016.59.9.355

피인용 문헌

  1. 성조숙증 치료에 대한 임상 연구 동향 -최근 중의학 저널을 중심으로- vol.31, pp.1, 2017, https://doi.org/10.7778/jpkm.2017.31.1.063
  2. 특발성 성조숙증으로 진단받은 환아 2례에 대한 증례보고 vol.31, pp.1, 2016, https://doi.org/10.7778/jpkm.2017.31.1.074
  3. 한약 치료를 이용한 여성 특발성 성조숙증의 임상연구에 대한 문헌고찰 vol.30, pp.3, 2016, https://doi.org/10.15204/jkobgy.2017.30.3.020
  4. 호르몬 치료를 받은 초등학교 여아의 성조숙증 경험 vol.25, pp.4, 2016, https://doi.org/10.5977/jkasne.2019.25.4.459
  5. Herbal Medicine for Idiopathic Central Precocious Puberty: A Systematic Review and Meta-Analysis vol.26, pp.11, 2016, https://doi.org/10.1089/acm.2019.0312