Asian Pacific Journal of Cancer Prevention

  • 제17권2호
  • /
  • Pages.647-653
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  • 2016
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  • 1513-7368(pISSN)
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  • 2476-762X(eISSN)
아시아태평양암예방학회 (Asian Pacific Journal of Cancer Prevention)
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Association of CYP2E1, STK15 and XRCC1 Polymorphisms with Risk of Breast Cancer in Malaysian Women

  • Chong, Eric Tzyy Jiann (Biotechnology Programme, Faculty of Science and Natural Resources, Universiti Malaysia Sabah) ;
  • Goh, Lucky Poh Wah (Biotechnology Programme, Faculty of Science and Natural Resources, Universiti Malaysia Sabah) ;
  • See, Edwin Un Hean (Surgery Department, Queen Elizabeth Hospital) ;
  • Chuah, Jitt Aun (Surgery Department, Queen Elizabeth Hospital) ;
  • Chua, Kek Heng (Department of Biomedical Science, Faculty of Medicine Building, University of Malaya) ;
  • Lee, Ping-Chin (Biotechnology Programme, Faculty of Science and Natural Resources, Universiti Malaysia Sabah)
  • 발행 : 2016.03.07
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초록

Background: Breast cancer is the most common type of cancer affecting Malaysian women. Recent statistics revealed that the cumulative probability of breast cancer and related deaths in Malaysia is higher than in most of the countries of Southeast Asia. Single nucleotide polymorphisms (SNPs) in CYP2E1 (rs6413432 and rs3813867), STK15 (rs2273535 and rs1047972) and XRCC1 (rs1799782 and rs25487) have been associated with breast cancer risk in a meta-analysis but any link in Southeast Asia, including Malaysia, remained to be determined. Hence, we investigated the relationship between these SNPs and breast cancer risk among Malaysian women in the present case-control study. Materials and Methods: Genomic DNA was isolated from peripheral blood of 71 breast cancer patients and 260 healthy controls and subjected to polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis. Results: Our study showed that the c1/c2 genotype or subjects with at least one c2 allele in CYP2E1 rs3813867 SNP had significantly increased almost 1.8-fold higher breast cancer risk in Malaysian women overall. In addition, the variant Phe allele in STK15 rs2273535 SNP appeared to protect against breast cancer in Malaysian Chinese. No significance association was found between XRCC1 SNPs and breast cancer risk in the population. Conclusions: This study provides additional knowledge on CYP2E1, STK15 and XRCC1 SNP impact of risk of breast cancer, particularly in the Malaysian population. From our findings, we also recommend Malaysian women to perform breast cancer screening before 50 years of age.

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참고문헌

  1. Bu T, Liu L, Sun Y, et al (2014). XRCC1 Arg399Gln polymorphism confers risk of breast cancer in American population: a meta-analysis of 10846 cases and 11723 controls. PLos ONE, 9, 86086. https://doi.org/10.1371/journal.pone.0086086
  2. Chong ETJ, Lee CC, Chua KH, Chuah JA, Lee PC (2014). RsaI but not DraI polymorphism in CYP2E1 gene increases the risk of gastrointestinal cancer in Malaysians: a case-control study. BMJ Open, 4, 4109.
  3. Cox DG, Hankinson SE, Hunter DJ (2006). Polymorphisms of the AURKA (STK15/Aurora kinase) gene and breast cancer risk (United States). Cancer Causes Control, 17, 81-3. https://doi.org/10.1007/s10552-005-0429-9
  4. Dai ZJ, Kang HF, Wang XJ, et al (2014). Association between genetic polymorphisms in AURKA (rs2273535 and rs1047972) and breast cancer risk: a meta-analysis involving 37,221 subjects. Cancer Cell Int, 14, 91. https://doi.org/10.1186/s12935-014-0091-y
  5. Ding PJ, Yang Y, Cheng LY, et al (2014). The relationship between seven common polymorphisms from five DNA repair genes and the risk for breast cancer in Northern Chinese women. PLoS ONE, 9, 92083. https://doi.org/10.1371/journal.pone.0092083
  6. Ewart-Toland A, Dai Q, Gao YT, et al (2005). Aurora-A/STK15 T+91A is a general low penetrance cancer susceptibility gene:a meta-analysis of multiple cancer types. Carcinogenesis, 26, 1368-73. https://doi.org/10.1093/carcin/bgi085
  7. Feng YZ, Liu YL, He XF, et al (2014). Association between the XRCC1 Arg194Trp polymorphism and risk of cancer: evidence from 201 case-control studies. Tumor Biol, 35, 10677-97. https://doi.org/10.1007/s13277-014-2326-x
  8. Fletcher O, Johnson N, Palles C, et al (2006). Inconsistent association between the STK15 F31I genetic polymorphism and breast cancer risk. J Natl Cancer Inst, 98, 1014-8. https://doi.org/10.1093/jnci/djj268
  9. Forouzanfar MH, Foreman KJ, Delossantos AM, et al (2011). Breast and cervical cancer in 187 countries between 1980 and 2010: a systematic analysis. Lancet, 378, 1461-84. https://doi.org/10.1016/S0140-6736(11)61351-2
  10. Goh LPW, Chong ETJ, Chua KH, Chuah JA, Lee PC (2014). Significant genotype difference in the CYP2E1 PstI polymorphism of indigenous groups in Sabah, Malaysia with Asian and non-Asian populations. Asian Pac J Cancer Prev, 15, 7377-81. https://doi.org/10.7314/APJCP.2014.15.17.7377
  11. Guengerich FP, Kim DH, Iwasaki M (1991). Role of human cytochrome P-450 IIE1 in the oxidation of many low molecular weight cancer suspects. Chem Res Toxicol, 4, 168-79. https://doi.org/10.1021/tx00020a008
  12. Guo XG, Zheng L, Feng WB, Xia Y (2014). The AURKA gene rs2273535 polymorphism contributes to breast carcinoma risk - meta-analysis of eleven studies. Asian Pac J Cancer Prev, 15, 6709-14. https://doi.org/10.7314/APJCP.2014.15.16.6709
  13. Higgins MJ, Baselga J (2011). Targeted therapies for breast cancer. J Clin Invest, 121, 3797-803. https://doi.org/10.1172/JCI57152
  14. Hisham AN, Yip CH (2004). Overview of breast cancer in Malaysian women: a problem with late diagnosis. Asian J Surg, 27, 130-3. https://doi.org/10.1016/S1015-9584(09)60326-2
  15. Hutchinson L (2010). Breast cancer: challenges, controversies, breakthroughs. Nat Rev Clic Oncol, 7, 669-70. https://doi.org/10.1038/nrclinonc.2010.192
  16. Khedhaier A, Hassen E, Bouaouina N, et al (2008). Implication of xenobiotic metabolizing enzyme gene (CYP2E1, CYP2C19, CYP2D6, mEH and NAT2) polymorphisms in breast carcinoma. BMC Cancer, 8, 109. https://doi.org/10.1186/1471-2407-8-109
  17. Kubota Y, Nash RA, Klungland A, et al (1996). Reconstitution of DNA base excision-repair with purified human protein: interaction between DNA polymerase beta and the XRCC1 protein. EMBO J, 15, 6662-70.
  18. Leong BDK, Chuah JA, Kumar VM, Yip CH (2007). Breast cancer in Sabah, Malaysia: a two year prospective study. Asian Pac J Cancer Prev, 8, 525-9.
  19. Leung T, Rajendran R, Singh S, et al (2013). Cytochrome P450 2E1 (CYP2E1) regulates the response to oxidative stress and migration of breast cancer cells. Breast Cancer Res, 15, R107. https://doi.org/10.1186/bcr3574
  20. Lim GCC, Yahaya H (2004). Second report of the national cancer incidence in Malaysia. National Cancer Registry Press, Kuala Lumpur, 47-8.
  21. Liu Y, He XF, Lu YT, et al (2013). Association between the XRCC1 Arg399Gln polymorphism and risk of cancer: evidence from 297 case-control studies. PLoS ONE, 8, 78071. https://doi.org/10.1371/journal.pone.0078071
  22. Liu ZQ, Zhang XS, Zhang SH (2014). Breast tumor subgroups reveal diverse clinical prognostic power. Sci Rep, 4, 4002.
  23. Malhotra GK, Zhao XS, Band H, Band V (2010). Histological, molecular and functional subtypes of breast cancers. Cancer Biol Ther, 10, 955-60. https://doi.org/10.4161/cbt.10.10.13879
  24. Mangia A, Malfettone A, Simone G, Darvishian F (2011). Old and new concepts in histopathological characterization of familial breast cancer. Ann Oncol, 22, 24-30. https://doi.org/10.1093/annonc/mdq305
  25. Pathy NB, Yip CH, Taib NA, et al (2011). Breast cancer in a multi-ethnic Asian setting: results from the Singapore-Malaysia hospital-based breast cancer registry. Breast, 20, 575-80.
  26. Perou CM, Sorlie T, Eisen MB, et al (2000). Molecular portraits of human breast tumors. Nature, 406, 747-52. https://doi.org/10.1038/35021093
  27. Qin J, He XF, Wei W, et al (2015). Association between the STK15 polymorphisms and risk of cancer: a meta-analysis. Mol Genet Genomics, 290, 97-114 https://doi.org/10.1007/s00438-014-0895-4
  28. Qin K, Wu C, Wu XT (2013). Two nonsynonymous polymorphisms (F31I and V57I) of the STK15 gene and breast cancer risk: a meta-analysis based on 5966 cases and 7609 controls. J Int Med Res, 41, 956-63. https://doi.org/10.1177/0300060513490087
  29. Ruan Y, Song AP, Wang H, et al (2011). Genetic polymorphisms in AURKA and BRCA1 are associated with breast cancer susceptibility in a Chinese Han population. J Pathol, 225, 535-43. https://doi.org/10.1002/path.2902
  30. Sangrajrang S, Sato Y, Sakamoto H, et al (2010). Genetic polymorphisms in folate and alcohol metabolism and breast cancer risk: a case-control study in Thai women. Breast Cancer Res Treat, 123, 885-93. https://doi.org/10.1007/s10549-010-0804-4
  31. Sen S, Zhou H, White RA (1997). A putative serine/threonine kinase encoding gene BTAK on chromosome 20q12 is amplified and overexpressed in human breast cancer cell lines. Oncogene, 14, 2195-200. https://doi.org/10.1038/sj.onc.1201065
  32. Sheikh MK, Khan FA, Imran Abdul Khalid K, Kumar G (2009). Age specific histologic types of carcinoma breast in Malaysians. J Coll Physicians Surg Pak, 19, 201-2.
  33. Staff S, Isola J, Jumppanen M, Tanner M (2010). Aurora-A gene is frequently amplified in basal-like breast cancer. Oncol Rep, 23, 307-12.
  34. Sultana R, Abdel-Fatah T, Abbotts R, et al (2012). Targeting XRCC1 deficiency in breast cancer for personalized therapy. Cancer Res, 73, 1621-34.
  35. Tang WF, Qiu H, Ding H, et al (2013). Association between the STK15 F31I polymorphism and cancer susceptibility: a metaanalysis involving 43,626 subjects. PLoS ONE, 8, 82790. https://doi.org/10.1371/journal.pone.0082790
  36. Vodicka P, Stetina R, Polakova V, et al (2007). Association of DNA repair polymorphisms with DNA repair functional outcomes in healthy human subjects. Carcinogenesis, 28, 657-64.
  37. Wu KS, Su DS, Lin K, Luo JY, Au WW (2011). XRCC1 Arg399Gln gene polymorphism and breast cancer risk: a meta-analysis based on case-control studies. Asian Pac J Cancer Prev, 12, 2237-43.
  38. Wu SH, Tsai SM, Hou MF, et al (2006). Interaction of genetic polymorphisms in cytochrome P450 2E1 and glutathione S-transferase M1 to breast cancer in Taiwanese women without smoking and drinking habits. Breast Cancer Res Treat, 100, 93-8. https://doi.org/10.1007/s10549-006-9226-8
  39. Xu L, Zhou X, Jiang F, Xu L, Yin R (2014). STK15 rs2273535 polymorphism and cancer risk: a meta-analysis of 74,896 subjects. Cancer Epidemiol, 38, 111-7. https://doi.org/10.1016/j.canep.2013.10.008
  40. Ye S, Rong J, Huang SH, et al (2012). XRCC1 and ADPRT polymorphisms associated with survival in breast cancer cases treated with chemotherapy. Asian Pac J Cancer Prev, 13, 4923-6. https://doi.org/10.7314/APJCP.2012.13.10.4923
  41. Yip CH, Pathy NB, Teo SH (2014). A review of breast cancer research in Malaysia. Med J Malaysia, 69, 8-22.
  42. Zgheib NK, Shamseddine AA, Geryess E, et al (2013). Genetic polymorphisms of CYP2E1, GST, and NAT2 enzymes are not associated with risk of breast cancer in a sample of Lebanese women. Mutat Res, 747-748, 40-7. https://doi.org/10.1016/j.mrfmmm.2013.04.004
  43. Zhou HY, Kuang J, Zhong L, et al (1998). Tumour amplified kinase STK15/BTAK induces centrosome amplification, aneuploidy and transformation. Nat Genet, 20, 189-93. https://doi.org/10.1038/2496

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