Journal of Yeungnam Medical Science

Yeungnam University College of Medicine, Yeungnam University Institute Medical Science (영남대 의대 학술지 편집위원회)
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Chronic hepatitis C healed by peginterferon-α and rivabirin treatment after kidney transplantation

만성 C형 간염의 신이식 환자에서 페그인터페론 알파와 리바비린 병합치료로 치유한 1예

  • Seok, Min Gue (Division of Gastroenterology and Hepatology, Department of Internal Medicine, Konyang University College of Medicine) ;
  • Lee, Tae Hee (Division of Gastroenterology and Hepatology, Department of Internal Medicine, Konyang University College of Medicine) ;
  • Yun, Sung Ro (Division of Gastroenterology and Hepatology, Department of Internal Medicine, Konyang University College of Medicine) ;
  • Hwang, Won Min (Division of Gastroenterology and Hepatology, Department of Internal Medicine, Konyang University College of Medicine) ;
  • Yoon, Se Hee (Division of Gastroenterology and Hepatology, Department of Internal Medicine, Konyang University College of Medicine) ;
  • Choe, In Soo (Division of Gastroenterology and Hepatology, Department of Internal Medicine, Konyang University College of Medicine) ;
  • Kang, Seong Joo (Division of Gastroenterology and Hepatology, Department of Internal Medicine, Konyang University College of Medicine) ;
  • Hong, Ju Young (Division of Gastroenterology and Hepatology, Department of Internal Medicine, Konyang University College of Medicine) ;
  • Kim, Dae Sung (Division of Gastroenterology and Hepatology, Department of Internal Medicine, Konyang University College of Medicine)
  • 석민규 (건양대학교 의과대학 내과학교실) ;
  • 이태희 (건양대학교 의과대학 내과학교실) ;
  • 윤성로 (건양대학교 의과대학 내과학교실) ;
  • 황원민 (건양대학교 의과대학 내과학교실) ;
  • 윤세희 (건양대학교 의과대학 내과학교실) ;
  • 최인수 (건양대학교 의과대학 내과학교실) ;
  • 강성주 (건양대학교 의과대학 내과학교실) ;
  • 홍주영 (건양대학교 의과대학 내과학교실) ;
  • 김대성 (건양대학교 의과대학 내과학교실)
  • Received : 2015.05.06
  • Accepted : 2015.07.27
  • Published : 2016.11.18
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Abstract

Hepatitis C virus (HCV) infection is present in a high proportion of patients with kidney transplantation. Compared with uninfected kidney transplant recipients, HCV infected kidney recipient have higher prevalence of liver disease and worse allograft survival after transplantation. Interferon monotherapy before transplantation is standard therapy for HCV-infected kidney transplant candidates. If HCV infection is discovered after transplantation, interferon monotherapy is considered due to the limited critical situation. However, in this patient, who was a kidney recipient, HCV infection was treated after kidney transplantation with peginterferon-${\alpha}$ and rivabirin. As a result, the patient achieved sustained virologic response.

Keywords

References

  1. Pereira BJ, Levey AS. Hepatitis C virus infection in dialysis and renal transplantation. Kidney Int 1997;51:981-99. https://doi.org/10.1038/ki.1997.139
  2. Aroldi A, Tarantino A, Montagnino G, Paparella M, Cesana B, Rumi MG, et al. Renal transplant recipients and chronic liver disease: statistical evaluation of predisposing factors. Nephron 1992;61:290-2. https://doi.org/10.1159/000186908
  3. Fabrizi F, Martin P, Ponticelli C. Hepatitis C virus infection and renal transplantation. Am J Kidney Dis 2001;38:919-34. https://doi.org/10.1053/ajkd.2001.28576
  4. Fishman JA, Rubin RH, Koziel MJ, Periera BJ. Hepatitis C virus and organ transplantation. Transplantation 1996;62:147-54. https://doi.org/10.1097/00007890-199607270-00001
  5. Kim DY, Kim IH, Jeong SH, Cho YK, Lee JH, Jin YJ, et al. A nationwide seroepidemiology of hepatitis C virus infection in South Korea. Liver Int 2013;33:586-94. https://doi.org/10.1111/liv.12108
  6. Kim H, Kim KT, Yoo JH, Kim BI, Lee SJ, Lee EJ, et al. Prevalence and risk factors of hepatitis C virus infection in chronic hamodialysis patients (multi-center study). Korean J Med 1997;52:833-40. Korean.
  7. Shin YH, Kim HK, Choi SD, Kim YS, Shin HS, Won YJ, et al. Prevalence of anti-HCV in hemodialysis patients in Taegu and Kyeongbuk, Korea. Korean J Med 1998;54:640-6. Korean.
  8. Bang BK, Yang CW, Yoon SA, Kim YS, Chang YS, Yoon YS, et al. Prevalence and clinical course of hepatitis B and hepatitis C liver disease in ciclosporin-treated renal allograft recipients. Nephron 1995;70:397-401. https://doi.org/10.1159/000188635
  9. Huang CC, Liaw YF, Lai MK, Chu SH, Chuang CK, Huang JY. The clinical outcome of hepatitis C virus antibody-positive renal allograft recipients. Transplantation 1992;53:763-5. https://doi.org/10.1097/00007890-199204000-00011
  10. Periera BJ, Wright TL, Schmid CH, Levey AS. The impact of pretransplantation hepatitis C infection on the outcome of renal transplantation. Transplantation 1995;60:799-805. https://doi.org/10.1097/00007890-199510000-00007
  11. Lee HJ. Effect of ${\alpha}$-interferon treatment on serum ALT levels in patients with chronic hepatitis C. Yeungnam Univ J Med 1993;10:190-6. Korean. https://doi.org/10.12701/yujm.1993.10.1.190
  12. Kamar N, Sandres-Saune K, Selves J, Ribes D, Cointault O, Durand D, et al. Long-term ribavirin therapy in hepatitis C virus-positive renal transplant patients: effects on renal function and liver histology. Am J Kidney Dis 2003;42:184-92. https://doi.org/10.1016/S0272-6386(03)00422-0
  13. Weclawiack H, Kamar N, Mehrenberger M, Guilbeau-Frugier C, Modesto A, Izopet J, et al. Alpha-interferon therapy for chronic hepatitis C may induce acute allograft rejection in kidney transplant patients with failed allografts. Nephrol Dial Transplant 2008;23:1043-7.
  14. Harihara Y, Kurooka Y, Yanagisawa T, Kuzuhara K, Otsubo O, Kumada H. Interferon therapy in renal allograft recipients with chronic hepatitis C. Transplant Proc 1994;26:2075.
  15. KDIGO clinical practice guidelines for the preventation, diagnosis, evaluation, and treatment of hepatitis C in chronic kidney disease. Kidney Int 2008;73(Suppl 109):S53-68. https://doi.org/10.1038/ki.2008.87
  16. Pereira BJ, Milford EL, Kirkman RL, Levey AS. Transmission of hepatitis C virus by organ transplantation. N Engl J Med 1991;325:454-60. https://doi.org/10.1056/NEJM199108153250702
  17. Chan TM, Lok AS, Cheng IK, Chan RT. Prevalence of hepatitis C virus infection in hemodialysis patients: a longitudinal study comparing the results of RNA and antibody assays. Hepatology 1993;17:5-8. https://doi.org/10.1002/hep.1840170103
  18. KDIGO clinical practice guidelines for the preventation, diagnosis, evaluation, and treatment of hepatitis C in chronic kidney disease. Kidney Int 2008;73(Suppl 109):S20-45. https://doi.org/10.1038/ki.2008.85
  19. Ning Q, Brown D, Parodo J, Cattral M, Gorczynski R, Cole E, et al. Ribavirin inhibits viral-induced macrophage production of TNF, IL-1, the procoagulant fgl2 prothrombinase and preserves Th1 cytokine production but inhibits Th2 cytokine response. J Immunol 1998;160:3487-93.