Journal of Radiopharmaceuticals and Molecular Probes (대한방사성의약품학회지)

Korean Society of Radiopharmaceuticals and Molecular Probes (대한방사성의약품학회)
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The development of a fully automated homemade system for [11C] acetate synthesis using an open source PLC

  • Kang, Se Hun (Molecular Imaging and Therapy Branch, Research Institute and Hospital, National Cancer Center) ;
  • Hong, Sung Tack (Department of Nuclear Medicine, Research Institute and Hospital, National Cancer Center) ;
  • Park, Kwangseo (Department of Nuclear Medicine, Research Institute and Hospital, National Cancer Center) ;
  • Kim, Seok-ki (Molecular Imaging and Therapy Branch, Research Institute and Hospital, National Cancer Center)
  • Received : 2016.10.04
  • Accepted : 2016.12.08
  • Published : 2016.12.30
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Abstract

Solid phase extraction (SPE) purification method is the efficient and well-known tool for automated [$^{11}C$]acetate synthesis. A fully automated homemade module adopting the SPE method and 'pinch' valves was developed very economically with a universal interface board, a relay card and an open source programmable logic controller. The radiochemical yield of the optimized [$^{11}C$]acetate synthesis by this system was $58.8{\pm}2.1%$ (n=10, decay-corrected) from $15.5{\pm}0.19GBq$ of $[^{11}C]CO_2$ as starting activity, and total synthetic time was 15 minutes. HPLC analysis showed its high radiochemical purity as $97.4{\pm}1.1%$ without possible by-products.

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References

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