Journal of the Korean Academy of Child and Adolescent Psychiatry

Korean Academy of Child and Adolescent Psychiatry (대한소아청소년정신의학회)
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Harmful Environmental Factors Leading to Attention-Deficit Hyperactivity Disorder

아동기 주의력결핍 과잉행동장애의 유해환경인자

  • Kwon, Ho Jang (Department of Preventive Medicine, College of Medicine, Dankook University) ;
  • Ha, Mina (Department of Preventive Medicine, College of Medicine, Dankook University) ;
  • Kim, Bung Nyun (Department of Psychiatry, College of Medicine, Seoul National University) ;
  • Lim, Myung Ho (Environmental Health Center, Dankook University Hospital)
  • 권호장 (단국대학교 의과대학 예방의학교실) ;
  • 하미나 (단국대학교 의과대학 예방의학교실) ;
  • 김붕년 (서울대학교 의과대학 정신건강의학교실) ;
  • 임명호 (단국대학교 의료원 환경보건센터)
  • Received : 2016.06.20
  • Accepted : 2016.11.09
  • Published : 2016.12.31
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Abstract

Attention-deficit hyperactivity disorder (ADHD) is a common, childhood-onset, neuropsychiatric disorder with an estimated prevalence of 2-7.6% in Korean children. Although the etiology of ADHD is not well understood, evidence from genetic factor and environmental factor studies suggests that ADHD results from a gene environmental interaction. In the current study, we reviewed the evidence for and clinical implications of the hypothetical roles of organophosphate pesticides, organochlorine pesticides, polychlorinated biphenyls, phthalate, bisphenol, polyfluoroalkyl chemicals, polycyclic aromatic hydrocarbons, mercury, lead, arsenic, cadmium, manganese, tobacco, alcohol as harmful risk factors in the development of ADHD.

Keywords

References

  1. Cho SC, Shin YO. Prevalence of disruptive behavior disorders. J Korean Acad Child Adolesc Psychiatry 1994;5:141-149.
  2. Eaves LJ, Silberg JL, Meyer JM, Maes HH, Simonoff E, Pickles A, et al. Genetics and developmental psychopathology: 2. The main effects of genes and environment on behavioral problems in the virginia twin study of adolescent behavioral development. J Child Psychol Psychiatry 1997;38:965-980. https://doi.org/10.1111/j.1469-7610.1997.tb01614.x
  3. Faraone SV, Perlis RH, Doyle AE, Smoller JW, Goralnick JJ, Holmgren MA, et al. Molecular genetics of attention-deficit/hyperactivity disorder. Biol Psychiatry 2005;57:1313-1323. https://doi.org/10.1016/j.biopsych.2004.11.024
  4. Jokanovic M. Medical treatment of acute poisoning with organophosphorus and carbamate pesticides. Toxicol Lett 2009;190:107- 115. https://doi.org/10.1016/j.toxlet.2009.07.025
  5. Timofeeva OA, Sanders D, Seemann K, Yang L, Hermanson D, Regenbogen S, et al. Persistent behavioral alterations in rats neonatally exposed to low doses of the organophosphate pesticide, parathion. Brain Res Bull 2008;77:404-411. https://doi.org/10.1016/j.brainresbull.2008.08.019
  6. Heath CJ, Picciotto MR. Nicotine-induced plasticity during development: modulation of the cholinergic system and long-term consequences for circuits involved in attention and sensory processing. Neuropharmacology 2009;56 Suppl 1:254-262.
  7. Rauh VA, Garfinkel R, Perera FP, Andrews HF, Hoepner L, Barr DB, et al. Impact of prenatal chlorpyrifos exposure on neurodevelopment in the first 3 years of life among inner-city children. Pediatrics 2006;118:e1845-e1859. https://doi.org/10.1542/peds.2006-0338
  8. Eskenazi B, Marks AR, Bradman A, Harley K, Barr DB, Johnson C, et al. Organophosphate pesticide exposure and neurodevelopment in young Mexican-American children. Environ Health Perspect 2007;115:792-798. https://doi.org/10.1289/ehp.9828
  9. Marks AR, Harley K, Bradman A, Kogut K, Barr DB, Johnson C, et al. Organophosphate pesticide exposure and attention in young Mexican-American children: the CHAMACOS study. Environ Health Perspect 2010;118:1768-1774. https://doi.org/10.1289/ehp.1002056
  10. Bouchard MF, Bellinger DC, Wright RO, Weisskopf MG. Attention- deficit/hyperactivity disorder and urinary metabolites of organophosphate pesticides. Pediatrics 2010;125:e1270-e1277. https://doi.org/10.1542/peds.2009-3058
  11. Lizardi PS, O'Rourke MK, Morris RJ. The effects of organophosphate pesticide exposure on Hispanic children's cognitive and behavioral functioning. J Pediatr Psychol 2008;33:91-101. https://doi.org/10.1093/jpepsy/jsm047
  12. Guodong D, Pei W, Ying T, Jun Z, Yu G, Xiaojin W, et al. Organophosphate pesticide exposure and neurodevelopment in young Shanghai children. Environ Sci Technol 2012;46:2911-2917. https://doi.org/10.1021/es202583d
  13. van Wendel de Joode B, Wesseling C, Kromhout H, Monge P, García M, Mergler D. Chronic nervous-system effects of long-term occupational exposure to DDT. Lancet 2001;357:1014-1016. https://doi.org/10.1016/S0140-6736(00)04249-5
  14. Schantz SL, Widholm JJ, Rice DC. Effects of PCB exposure on neuropsychological function in children. Environ Health Perspect 2003;111:357-576. https://doi.org/10.1289/ehp.5461
  15. Sagiv SK, Nugent JK, Brazelton TB, Choi AL, Tolbert PE, Altshul LM, et al. Prenatal organochlorine exposure and measures of behavior in infancy using the Neonatal Behavioral Assessment Scale (NBAS). Environ Health Perspect 2008;116:666-673. https://doi.org/10.1289/ehp.10553
  16. Vreugdenhil HJ, Mulder PG, Emmen HH, Weisglas-Kuperus N. Effects of perinatal exposure to PCBs on neuropsychological functions in the Rotterdam cohort at 9 years of age. Neuropsychology 2004;18:185-193. https://doi.org/10.1037/0894-4105.18.1.185
  17. Jacobson JL, Jacobson SW. Prenatal exposure to polychlorinated biphenyls and attention at school age. J Pediatr 2003;143:780-788. https://doi.org/10.1067/S0022-3476(03)00577-8
  18. Stewart P, Fitzgerald S, Reihman J, Gump B, Lonky E, Darvill T, et al. Prenatal PCB exposure, the corpus callosum, and response inhibition. Environ Health Perspect 2003;111:1670-1677. https://doi.org/10.1289/ehp.6173
  19. Grandjean P, Weihe P, Burse VW, Needham LL, Storr-Hansen E, Heinzow B, et al. Neurobehavioral deficits associated with PCB in 7-year-old children prenatally exposed to seafood neurotoxicants. Neurotoxicol Teratol 2001;23:305-317. https://doi.org/10.1016/S0892-0362(01)00155-6
  20. Lee DH, Jacobs DR, Porta M. Association of serum concentrations of persistent organic pollutants with the prevalence of learning disability and attention deficit disorder. J Epidemiol Community Health 2007;61:591-596. https://doi.org/10.1136/jech.2006.054700
  21. Nakajima S, Saijo Y, Kato S, Sasaki S, Uno A, Kanagami N, et al. Effects of prenatal exposure to polychlorinated biphenyls and dioxins on mental and motor development in Japanese children at 6 months of age. Environ Health Perspect 2006;114:773-778.
  22. Daniels JL, Longnecker MP, Klebanoff MA, Gray KA, Brock JW, Zhou H, et al. Prenatal exposure to low-level polychlorinated biphenyls in relation to mental and motor development at 8 months. Am J Epidemiol 2003;157:485-492. https://doi.org/10.1093/aje/kwg010
  23. Masuo Y, Morita M, Oka S, Ishido M. Motor hyperactivity caused by a deficit in dopaminergic neurons and the effects of endocrine disruptors: a study inspired by the physiological roles of PACAP in the brain. Regul Pept 2004;123:225-234. https://doi.org/10.1016/j.regpep.2004.05.010
  24. Ghisari M, Bonefeld-Jorgensen EC. Effects of plasticizers and their mixtures on estrogen receptor and thyroid hormone functions. Toxicol Lett 2009;189:67-77. https://doi.org/10.1016/j.toxlet.2009.05.004
  25. Engel SM, Zhu C, Berkowitz GS, Calafat AM, Silva MJ, Miodovnik A, et al. Prenatal phthalate exposure and performance on the Neonatal Behavioral Assessment Scale in a multiethnic birth cohort. Neurotoxicology 2009;30:522-528. https://doi.org/10.1016/j.neuro.2009.04.001
  26. Kim BN, Cho SC, Kim Y, Shin MS, Yoo HJ, Kim JW, et al. Phthalates exposure and attention-deficit/hyperactivity disorder in schoolage children. Biol Psychiatry 2009;66:958-963. https://doi.org/10.1016/j.biopsych.2009.07.034
  27. Park S, Lee JM, Kim JW, Cheong JH, Yun HJ, Hong YC, et al. Association between phthalates and externalizing behaviors and cortical thickness in children with attention deficit hyperactivity disorder. Psychol Med 2015;45:1601-1612. https://doi.org/10.1017/S0033291714002694
  28. Hong SB, Im MH, Kim JW, Park EJ, Shin MS, Kim BN, et al. Environmental lead exposure and attention deficit/hyperactivity disorder symptom domains in a community sample of South Korean school-age children. Environ Health Perspect 2015;123:271-276.
  29. Welshons WV, Nagel SC, vom Saal FS. Large effects from small exposures. III. Endocrine mechanisms mediating effects of bisphenol A at levels of human exposure. Endocrinology 2006;147(6 Suppl):S56-S69. https://doi.org/10.1210/en.2005-1159
  30. Braun JM, Yolton K, Dietrich KN, Hornung R, Ye X, Calafat AM, et al. Prenatal bisphenol A exposure and early childhood behavior. Environ Health Perspect 2009;117:1945-1952. https://doi.org/10.1289/ehp.0900979
  31. Longnecker MP. Human data on bisphenol A and neurodevelopment. Environ Health Perspect 2009;117:A531-A532. https://doi.org/10.1289/ehp.0901610
  32. Hong SB, Hong YC, Kim JW, Park EJ, Shin MS, Kim BN, et al. Bisphenol A in relation to behavior and learning of school-age children. J Child Psychol Psychiatry 2013;54:890-899. https://doi.org/10.1111/jcpp.12050
  33. Slotkin TA, MacKillop EA, Melnick RL, Thayer KA, Seidler FJ. Developmental neurotoxicity of perfluorinated chemicals modeled in vitro. Environ Health Perspect 2008;116:716-722. https://doi.org/10.1289/ehp.11253
  34. Hoffman K, Webster TF, Weisskopf MG, Weinberg J, Vieira VM. Exposure to polyfluoroalkyl chemicals and attention deficit/hyperactivity disorder in U.S. children 12-15 years of age. Environ Health Perspect 2010;118:1762-1767. https://doi.org/10.1289/ehp.1001898
  35. Fei C, McLaughlin JK, Lipworth L, Olsen J. Prenatal exposure to perfluorooctanoate (PFOA) and perfluorooctanesulfonate (PFOS) and maternally reported developmental milestones in infancy. Environ Health Perspect 2008;116:1391-1395. https://doi.org/10.1289/ehp.11277
  36. Lundqvist C, Zuurbier M, Leijs M, Johansson C, Ceccatelli S, Saunders M, et al. The effects of PCBs and dioxins on child health. Acta Paediatr Suppl 2006;95:55-64.
  37. Perera FP, Wang S, Vishnevetsky J, Zhang B, Cole KJ, Tang D, et al. Polycyclic aromatic hydrocarbons-aromatic DNA adducts in cord blood and behavior scores in New York city children. Environ Health Perspect 2011;119:1176-1181. https://doi.org/10.1289/ehp.1002705
  38. Atchison WD, Hare MF. Mechanisms of methylmercury-induced neurotoxicity. FASEB J 1994;8:622-629. https://doi.org/10.1096/fasebj.8.9.7516300
  39. Debes F, Budtz-Jorgensen E, Weihe P, White RF, Grandjean P. Impact of prenatal methylmercury exposure on neurobehavioral function at age 14 years. Neurotoxicol Teratol 2006;28:363-375. https://doi.org/10.1016/j.ntt.2006.02.004
  40. Julvez J, Debes F, Weihe P, Choi A, Grandjean P. Sensitivity of continuous performance test (CPT) at age 14 years to developmental methylmercury exposure. Neurotoxicol Teratol 2010;32:627-632. https://doi.org/10.1016/j.ntt.2010.08.001
  41. Myers GJ, Davidson PW, Cox C, Shamlaye CF, Palumbo D, Cernichiari E, et al. Prenatal methylmercury exposure from ocean fish consumption in the Seychelles child development study. Lancet 2003;361:1686-1692. https://doi.org/10.1016/S0140-6736(03)13371-5
  42. Nicolescu R, Petcu C, Cordeanu A, Fabritius K, Schlumpf M, Krebs R, et al. Environmental exposure to lead, but not other neurotoxic metals, relates to core elements of ADHD in Romanian children: performance and questionnaire data. Environ Res 2010;110:476- 483. https://doi.org/10.1016/j.envres.2010.04.002
  43. Cheuk DK, Wong V. Attention-deficit hyperactivity disorder and blood mercury level: a case-control study in Chinese children. Neuropediatrics 2006;37:234-240. https://doi.org/10.1055/s-2006-924577
  44. Ha M, Kwon HJ, Lim MH, Jee YK, Hong YC, Leem JH, et al. Low blood levels of lead and mercury and symptoms of attention deficit hyperactivity in children: a report of the children's health and environment research (CHEER). Neurotoxicology 2009;30:31-36. https://doi.org/10.1016/j.neuro.2008.11.011
  45. Suzuki K, Nakai K, Sugawara T, Nakamura T, Ohba T, Shimada M, et al. Neurobehavioral effects of prenatal exposure to methylmercury and PCBs, and seafood intake: Neonatal Behavioral Assessment Scale results of Tohoku study of child development. Environ Res 2010;110:699-704. https://doi.org/10.1016/j.envres.2010.07.001
  46. Needleman HL. Lead and impaired abilities. Dev Med Child Neurol 1982;24:196-198.
  47. Centers for Disease Control and Prevention (CDC). Preventing lead poisoning in young children. Atlanta: Centers for Disease Control and Prevention;2005.
  48. Lanphear BP, Hornung R, Khoury J, Yolton K, Baghurst P, Bellinger DC, et al. Low-level environmental lead exposure and children's intellectual function: an international pooled analysis. Environ Health Perspect 2005;113:894-899. https://doi.org/10.1289/ehp.7688
  49. Jusko TA, Henderson CR, Lanphear BP, Cory-Slechta DA, Parsons PJ, Canfield RL. Blood lead concentrations < 10 microg/dL and child intelligence at 6 years of age. Environ Health Perspect 2008;116: 243-248. https://doi.org/10.1289/ehp.116-a243
  50. Solon O, Riddell TJ, Quimbo SA, Butrick E, Aylward GP, Lou Bacate M, et al. Associations between cognitive function, blood lead concentration, and nutrition among children in the central Philippines. J Pediatr 2008;152:237-243. https://doi.org/10.1016/j.jpeds.2007.09.008
  51. Braun JM, Kahn RS, Froehlich T, Auinger P, Lanphear BP. Exposures to environmental toxicants and attention deficit hyperactivity disorder in U.S. children. Environ Health Perspect 2006;114:1904-1909.
  52. Froehlich TE, Lanphear BP, Auinger P, Hornung R, Epstein JN, Braun J, et al. Association of tobacco and lead exposures with attention- deficit/hyperactivity disorder. Pediatrics 2009;124:e1054-e1063. https://doi.org/10.1542/peds.2009-0738
  53. Kim Y, Cho SC, Kim BN, Hong YC, Shin MS, Yoo HJ, et al. Association between blood lead levels $<5 {\mu}g/dL$) and inattention-hyperactivity and neurocognitive profiles in school-aged Korean children. Sci Total Environ 2010;408:5737-5743. https://doi.org/10.1016/j.scitotenv.2010.07.070
  54. Cho SC, Kim BN, Hong YC, Shin MS, Yoo HJ, Kim JW, et al. Effect of environmental exposure to lead and tobacco smoke on inattentive and hyperactive symptoms and neurocognitive performance in children. J Child Psychol Psychiatry 2010;51:1050-1057. https://doi.org/10.1111/j.1469-7610.2010.02250.x
  55. Wang HL, Chen XT, Yang B, Ma FL, Wang S, Tang ML, et al. Casecontrol study of blood lead levels and attention deficit hyperactivity disorder in Chinese children. Environ Health Perspect 2008;116: 1401-1406. https://doi.org/10.1289/ehp.11400
  56. Choi WJ, Kwon HJ, Lim MH, Lim JA, Ha M. Blood lead, parental marital status and the risk of attention-deficit/hyperactivity disorder in elementary school children: a longitudinal study. Psychiatry Res 2016;236:42-46. https://doi.org/10.1016/j.psychres.2016.01.002
  57. Agency for Toxic Substances and Disease Registry. The priority list of hazardous substances, 2011. Atlanta, GA: U.S. Department of Health and Human Services, Public Health Services;2011.
  58. Rodriguez-Barranco M, Lacasana M, Aguilar-Garduno C, Alguacil J, Gil F, Gonzalez-Alzaga B, et al. Association of arsenic, cadmium and manganese exposure with neurodevelopment and behavioural disorders in children: a systematic review and metaanalysis. Sci Total Environ 2013;454-455:562-577. https://doi.org/10.1016/j.scitotenv.2013.03.047
  59. Rocha-Amador D, Navarro ME, Carrizales L, Morales R, Calderon J. Decreased intelligence in children and exposure to fluoride and arsenic in drinking water. Cad Saude Publica 2007;23 Suppl 4: S579-S587. https://doi.org/10.1590/S0102-311X2007001600018
  60. Abbas S, Qureshi EMA, Ahmad F, Vehra S, Khan AU. An assessment of relationship between arsenic in drinking water, health status and intellectual functioning of children in district Kasur. Pak J Nutr 2012;11:150-153. https://doi.org/10.3923/pjn.2012.150.153
  61. Wang SX, Wang ZH, Cheng XT, Li J, Sang ZP, Zhang XD, et al. Arsenic and fluoride exposure in drinking water: children's IQ and growth in Shanyin county, Shanxi province, China. Environ Health Perspect 2007;115:643-647. https://doi.org/10.1289/ehp.9270
  62. Wasserman GA, Liu X, Parvez F, Ahsan H, Factor-Litvak P, van Geen A, et al. Water arsenic exposure and children's intellectual function in Araihazar, Bangladesh. Environ Health Perspect 2004; 112:1329-1333. https://doi.org/10.1289/ehp.6964
  63. Wasserman GA, Liu X, Parvez F, Ahsan H, Factor-Litvak P, Kline J, et al. Water arsenic exposure and intellectual function in 6-yearold children in Araihazar, Bangladesh. Environ Health Perspect 2007;115:285-289.
  64. Parvez F, Wasserman GA, Factor-Litvak P, Liu X, Slavkovich V, Siddique AB, et al. Arsenic exposure and motor function among children in Bangladesh. Environ Health Perspect 2011;119:1665- 1670. https://doi.org/10.1289/ehp.1103548
  65. Tsai SY, Chou HY, The HW, Chen CM, Chen CJ. The effects of chronic arsenic exposure from drinking water on the neurobehavioral development in adolescence. Neurotoxicology 2003;24:747- 753. https://doi.org/10.1016/S0161-813X(03)00029-9
  66. Rosado JL, Ronquillo D, Kordas K, Rojas O, Alatorre J, Lopez P, et al. Arsenic exposure and cognitive performance in Mexican schoolchildren. Environ Health Perspect 2007;115:1371-1375. https://doi.org/10.1289/ehp.9961
  67. von Ehrenstein OS, Poddar S, Yuan Y, Mazumder DG, Eskenazi B, Basu A, et al. Children's intellectual function in relation to arsenic exposure. Epidemiology 2007;18:44-51. https://doi.org/10.1097/01.ede.0000248900.65613.a9
  68. U.S. Department of the Interior, U.S. Geological Survey. Mineral commodity summaries 2011. Reston, Virginia: U.S. Geological Survey;2011.
  69. Cao Y, Chen A, Radcliffe J, Dietrich KN, Jones RL, Caldwell K, et al. Postnatal cadmium exposure, neurodevelopment, and blood pressure in children at 2, 5, and 7 years of age. Environ Health Perspect 2009;117:1580-1586. https://doi.org/10.1289/ehp.0900765
  70. Tian LL, Zhao YC, Wang XC, Gu JL, Sun ZJ, Zhang YL, et al. Effects of gestational cadmium exposure on pregnancy outcome and development in the offspring at age 4.5 years. Biol Trace Elem Res 2009;132:51-59. https://doi.org/10.1007/s12011-009-8391-0
  71. Bao QS, Lu CY, Song H, Wang M, Ling W, Chen WQ, et al. Behavioural development of school-aged children who live around a multi-metal sulphide mine in Guangdong province, China: a crosssectional study. BMC Public Health 2009;9:217. https://doi.org/10.1186/1471-2458-9-217
  72. Yousef S, Adem A, Zoubeidi T, Kosanovic M, Mabrouk AA, Eapen V. Attention deficit hyperactivity disorder and environmental toxic metal exposure in the United Arab Emirates. J Trop Pediatr 2011;57:457-460. https://doi.org/10.1093/tropej/fmq121
  73. Bouchard M, Laforest F, Vandelac L, Bellinger D, Mergler D. Hair manganese and hyperactive behaviors: pilot study of school-age children exposed through tap water. Environ Health Perspect 2007;115:122-127. https://doi.org/10.1289/ehp.9360
  74. Farias AC, Cunha A, Benko CR, McCracken JT, Costa MT, Farias LG, et al. Manganese in children with attention-deficit/hyperactivity disorder: relationship with methylphenidate exposure. J Child Adolesc Psychopharmacol 2010;20:113-118. https://doi.org/10.1089/cap.2009.0073
  75. Ericson JE, Crinella FM, Clarke-Stewart KA, Allhusen VD, Chan T, Robertson RT. Prenatal manganese levels linked to childhood behavioral disinhibition. Neurotoxicol Teratol 2007;29:181-187. https://doi.org/10.1016/j.ntt.2006.09.020
  76. Khan K, Factor-Litvak P, Wasserman GA, Liu X, Ahmed E, Parvez F, et al. Manganese exposure from drinking water and children's classroom behavior in Bangladesh. Environ Health Perspect 2011; 119:1501-1506. https://doi.org/10.1289/ehp.1003397
  77. Kim Y, Kim BN, Hong YC, Shin MS, Yoo HJ, Kim JW, et al. Co-exposure to environmental lead and manganese affects the intelligence of school-aged children. Neurotoxicology 2009;30:564-571. https://doi.org/10.1016/j.neuro.2009.03.012
  78. Wasserman RC, Kelleher KJ, Bocian A, Baker A, Childs GE, Indacochea F, et al. Identification of attentional and hyperactivity problems in primary care: a report from pediatric research in office settings and the ambulatory sentinel practice network. Pediatrics 1999;103:E38. https://doi.org/10.1542/peds.103.3.e38
  79. Mick E, Biederman J, Prince J, Fischer MJ, Faraone SV. Impact of low birth weight on attention-deficit hyperactivity disorder. J Dev Behav Pediatr 2002;23:16-22. https://doi.org/10.1097/00004703-200202000-00004
  80. Slotkin TA. Fetal nicotine or cocaine exposure: which one is worse? J Pharmacol Exp Ther 1998;285:931-945.
  81. Kotimaa AJ, Moilanen I, Taanila A, Ebeling H, Smalley SL, Mc- Gough JJ, et al. Maternal smoking and hyperactivity in 8-year-old children. J Am Acad Child Adolesc Psychiatry 2003;42:826-833. https://doi.org/10.1097/01.CHI.0000046866.56865.A2
  82. Hill SY, Lowers L, Locke-Wellman J, Shen SA. Maternal smoking and drinking during pregnancy and the risk for child and adolescent psychiatric disorders. J Stud Alcohol 2000;61:661-668. https://doi.org/10.15288/jsa.2000.61.661
  83. Lindblad F, Hjern A. ADHD after fetal exposure to maternal smoking. Nicotine Tob Res 2010;12:408-415. https://doi.org/10.1093/ntr/ntq017
  84. Arnold LE, DiSilvestro RA. Zinc in attention-deficit/hyperactivity disorder. J Child Adolesc Psychopharmacol 2005;15:619-627. https://doi.org/10.1089/cap.2005.15.619
  85. Han JY, Kwon HJ, Ha M, Paik KC, Lim MH, Lee SG, et al. The effects of prenatal exposure to alcohol and environmental tobacco smoke on risk for ADHD: a large population-based study. Psychiatry Res 2015;225:164-168. https://doi.org/10.1016/j.psychres.2014.11.009
  86. Banerjee TD, Middleton F, Faraone SV. Environmental risk factors for attention-deficit hyperactivity disorder. Acta Paediatr 2007;96: 1269-1274. https://doi.org/10.1111/j.1651-2227.2007.00430.x
  87. Knopik VS, Sparrow EP, Madden PA, Bucholz KK, Hudziak JJ, Reich W, et al. Contributions of parental alcoholism, prenatal substance exposure, and genetic transmission to child ADHD risk: a female twin study. Psychol Med 2005;35:625-635. https://doi.org/10.1017/S0033291704004155
  88. Delaney-Black V, Covington C, Templin T, Ager J, Nordstrom- Klee B, Martier S, et al. Teacher-assessed behavior of children prenatally exposed to cocaine. Pediatrics 2000;106:782-791. https://doi.org/10.1542/peds.106.4.782
  89. Romano E, Tremblay RE, Farhat A, Cote S. Development and prediction of hyperactive symptoms from 2 to 7 years in a populationbased sample. Pediatrics 2006;117:2101-2110. https://doi.org/10.1542/peds.2005-0651
  90. Sood B, Delaney-Black V, Covington C, Nordstrom-Klee B, Ager J, Templin T, et al. Prenatal alcohol exposure and childhood behavior at age 6 to 7 years: I. dose-response effect. Pediatrics 2001;108: E34. https://doi.org/10.1542/peds.108.2.e34
  91. Bhatara V, Loudenberg R, Ellis R. Association of attention deficit hyperactivity disorder and gestational alcohol exposure: an exploratory study. J Atten Disord 2006;9:515-522. https://doi.org/10.1177/1087054705283880

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