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Gene Expression Related to Cognitive Function in Growth Hormone-treated Mice with Prader-Willi Syndrome

  • Ko, Ah-Ra (Research Institute for Future Medicine, Samsung Biomedical Research Institute)
  • Received : 2016.11.30
  • Accepted : 2016.12.13
  • Published : 2016.12.31

Abstract

Prader-Willi syndrome (PWS) is a rare genetic disorder often caused by a deletion of the chromosome 15q11-q13 region inherited from the father or by maternal disomy 15. Growth hormone deficiency with short stature, hypogonadism, cognitive and behavioral problems, analgesia, decreased gastric motility and decreased ability to vomit with hyperphagia are common in PWS leading to severe obesity in early childhood, if not controlled. The goal of this study is to investigate the effects of recombinant human GH (rhGH, henceforth designated GH) on the gene expression related to cognitive function in the brain of PWS mouse model (Snord116del). GH restored the mRNA expression level of several genes in the cerebellum. These data suggest the effect of GH on the expression of cognitive function related genes in cerebellum may provide a mechanism for the GH-induced brain function in PWS patients.

Keywords

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