Asian Pacific Journal of Cancer Prevention

Asian Pacific Journal of Cancer Prevention (아시아태평양암예방학회)
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Evaluation of Methylobacterium radiotolerance and Sphyngomonas yanoikoaie in Sentinel Lymph Nodes of Breast Cancer Cases

  • Yazdi, Hamid Reza (Department of Microbiology, Pishva Islamic Azad Uinversity) ;
  • Movafagh, Abolfazl (Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences) ;
  • Fallah, Fateme (Department of Microbiology, School of Medicine, Shahid Beheshti University of Medical Sciences) ;
  • Shargh, Shohreh Alizadeh (Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences) ;
  • Mansouri, Neda (Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences) ;
  • Pour, Atefeh Heidary (Department of Cell and Molecular Biology, Pharmaceutical Sciences Branch, Islamic Azad University) ;
  • Hashemi, Mehrdad (Department of Genetic, Islamic Azad University, Tehran Medical Sciences Branch)
  • Published : 2016.06.01
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Abstract

It has been established that different kinds of bacteria agents are involved in various cancers. Although the mechanism of tumorigenesis is not clearly understood, there is evidence for the presence of bacteria within tumors, with at least a progression effect for some bacteria that prepare suitable microenvironments for tumor cell growth. The aim of current study was to evaluate bacterial dysbiosis in sentinel lymph nodes of breast cancer patients. One hundred and twenty three fresh-frozen sentinel lymph nodes and a corresponding number of normal adjacent breast tissue specimens and five normal mastectomy samples were investigated employing RT-PCR. In addition using genus-specific primers were applied. There was a significant differences as presence of Methylobacterium radiotolerance DNA recorded between patients and normal control group (p= 0.0). Based on our research work, further studies into the role of microbes in breast cancer would be of great interest.

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