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T- Lymphocyte Subset (CD4 /CD8) Ratios of Breast Cancer Patients in Basra-Iraq and Baku-Azerbaijan

  • Published : 2016.06.01

Abstract

Breast cancer is the most common cancer among the population as a whole and among females, yet it is highly curable if diagnosed at an early stage. Different methods are used to diagnose breast cancer. One of these methods features immunological tests using flow cytometry to determine T-lymphocyte (CD4/CD8) ratios in peripheral blood. One hundred patients with breast cancer (50 from Basra, Iraq, and 50 from Baku, Azerbaijan) confirmed to have breast cancer by histopathology were studied. Blood samples were collected from all patients before initiation of treatment and were used for analysis. The mean age of women from Basra was $51.2{\pm}10.7years$ and that of women from Baku was slightly higher at $54.8{\pm}12.2$. The mean CD4/CD8 ratio in Basra was 1.4 and in Baku was 1.8 with P value < 0.05. The percentage of Basra patients who have CD4/CD8 value less than 1 was 50%, while the percentage for Baku patients was 24 % (p < 0.05). While the CD4/CD8 T-lymphocyte ratio might be useful for early diagnosis in patients with breast cancer parallel with other confirmed tests factors involved in explaining variation between countries such as that observed here need to be taken into account.

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References

  1. Black MM. (1977). Immunopathology of breast cancer. Pathobiol Annu, 7, 213-30
  2. Farhad RR, Soheila A, Ramesh O, et al (2015). Comparative analysis of CD4 ,CD8 T cells in tumor tissue, lymph nodes and peripheral blood from patients with breast cancer. Iranian B j 19, 35-44.
  3. Liyange UK, Moree TT, Joo HG et al (2002). Prevalence of regulatory T cells is inceased in peripheral blood and tumor microenvironment of patients with pancreas or breast adenocarcinoma. J Immunol, 169, 2756-61. https://doi.org/10.4049/jimmunol.169.5.2756
  4. Macchetti AH, Marana HRC, Silva JS, et al (2006). Tumor infiltrating CD4 T lymphocytes in early cancer reflect lymph node involvement. Cliinics, 61, 203-8.
  5. Mahmoud SM, Paish EC, Powe DG, et al (2011). Tumor infiltrating CD8 lymphocytes predict clinical outcome in breast cancer. J Clinc Oncol, 29, 1949-55. https://doi.org/10.1200/JCO.2010.30.5037
  6. Vagenopoulo S, Lazaris AC, Markopolus C, et al (2003). Immunohistochemical evaluation of immune response in invasive ductal breast cancer of not-otherwise = specified type. Breast, 12, 172-8. https://doi.org/10.1016/S0960-9776(03)00004-3
  7. Warne ET, Tamimi RM, Hughes ME, et al (2014). Racial and ethnic differences in breast cancer survival. J Clin Oncol, 33, 2254-61.
  8. Westermann J, Pabst R (1990). Lymphocyte subsets in the blood: a diagnostic window on the lymphoid system. Immunol Today, 11, 406-10. https://doi.org/10.1016/0167-5699(90)90160-B
  9. Yo-Ping L, Chung-Jiuan J, Shu-ching C (2011). The roles of CD4 T cell in tumor immunity. J Immunol, 6, 65-72.