생약학회지 (Korean Journal of Pharmacognosy)

  • 제47권4호
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  • Pages.295-300
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  • 2016
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  • 0253-3073(pISSN)
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  • 2288-9299(eISSN)
한국생약학회 (The Korean Society of Pharmacognosy)
권호 표지

LPS유도 대식세포에서 Kaempferol-7-O-β-D-glucoside의 NO, PGE2 및 염증성 사이토카인 생성 저해 효과

Inhibitory Effects of Kaempferol-7-O-β-D-glucoside on LPS-induced NO, PGE2 and Inflammatory Cytokines Production in RAW264.7 Macrophages

  • 박종철 (국립순천대학교 생명산업과학대학 한약자원개발학과) ;
  • 한희수 (경희대학교 약학대학 약품생화학실) ;
  • 이승빈 (경희대학교 약학대학 약품생화학실) ;
  • 이경태 (경희대학교 약학대학 약품생화학실)
  • Park, Jong Cheol (Department of Oriental Medicine Resources, College of Life Science and Natural Resources, Suncheon National University) ;
  • Han, Hee-Soo (Department of Pharmaceutical Biochemistry, College of Pharmacy, Kyung-Hee University) ;
  • Lee, Seung-Bin (Department of Pharmaceutical Biochemistry, College of Pharmacy, Kyung-Hee University) ;
  • Lee, Kyung-Tae (Department of Pharmaceutical Biochemistry, College of Pharmacy, Kyung-Hee University)
  • 투고 : 2016.07.19
  • 심사 : 2016.10.13
  • 발행 : 2016.12.30
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초록

Flavonoids are widely reported to be beneficial to human health. Among flavonoids, in general, flavonoid aglycons have better biological activities than flavonoid glycosides, in that aglycons can easily penetrate through cell membrane because of their low polarity. Therefore, kaempferol, quercetin and various their glycosides were evaluated for their abilities to inhibit NO and $PGE_2$ productions in LPS-induced RAW 264.7 cells. Of these flavonoids and flavonoid glycosides, kaempferol-7-O-${\beta}$-D-glucoside(kp-7-glu) which possesses a glycoside at C-7 position of the A ring in kaempferol, potently inhibited NO, $PGE_2$ and $TNF-{\alpha}$, $IL-1{\beta}$, IL-6 productions in LPS-induced RAW 264.7 macrophages.

키워드

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