The Journal of Internal Korean Medicine (대한한방내과학회지)

The Society of Internal Korean Medicine (대한한방내과학회)
권호 표지
DOI QR코드

DOI QR Code

Two Cases of Correlation between Improvement of General Weakness Symptoms and DHEAS Level through Korean Medical Treatment

한방치료를 통한 허로환자의 증상개선과 DHEAS 수치개선의 연관성에 관한 증례보고 2례

  • Lee, He-sol (Dept. of Oriental Internal Medicine, Gil Oriental Medical Hospital, Ga-Chon University) ;
  • Jun, Chan-young (Dept. of Oriental Internal Medicine, Gil Oriental Medical Hospital, Ga-Chon University) ;
  • Choi, You-kyung (Dept. of Oriental Internal Medicine, Gil Oriental Medical Hospital, Ga-Chon University)
  • 이해솔 (가천대학교 부속 길한방병원 한방내과) ;
  • 전찬용 (가천대학교 부속 길한방병원 한방내과) ;
  • 최유경 (가천대학교 부속 길한방병원 한방내과)
  • Received : 2016.12.09
  • Accepted : 2016.12.29
  • Published : 2016.12.30
Download PDF
⟨ Previous Next ⟩

Abstract

Objectives: This study reports on the efficacy of treating patients with general weakness symptoms with Korean medicine. Methods: Two patients with general weakness symptoms were treated with Korean medical treatment modalities, including acupuncture, moxibustion, and herbal medicines. Blood tests, the visual analogue scale (VAS), and patients' complaints were used to assess the treatment effects. Results and Conclusions: dehydroepiandrosterone sulphate (DHEAS), DHEAS/cortisol index, VAS, and the patients' complaints improved after treatment. Korean medical treatment is effective in improving DHEAS and the DHEAS/cortisol index according to the improvements in the patients' conditions. However, more studies are required to validate its use with other patients.

Keywords

References

  1. Cho YS, Je JT, Lee SK. Effect of sleep-restriction on Salivary Adrenal Hormones in Korean Adolescent. Korean J Oriental Physiology & Pathology 2011;25(2):311-7.
  2. Du CL, Lin MC, Lu L, Tai JJ. Correlation of Occupational Stress Index with 24-hour Urine Cortisol and Serum DHEA Sulfate among City Bus Drivers: A Cross-sectional Study. Saf Health Work 2011 Jun;2(2):169-75. https://doi.org/10.5491/SHAW.2011.2.2.169
  3. Alhaj HA, Massey AE, McAllister-Williams RH. Effects of DHEA administration on episodic memory, cortisol and mood in healthy young men: a double blind, placebo-controlled study. Psychopharmacology(Berl) 2006;188:541-51. https://doi.org/10.1007/s00213-005-0136-y
  4. Morales AJ, Haubrich RH, Hwang JY, Asakura H, Yen SS. The effect of six months treatment with a 100 mg daily dose of dehydroepiandrosterone (DHEA) on circulating sex steroids, body composition and muscle strength in age-advanced men and women. Clin Endocrinol(Oxf) 1998; 49:421-32. https://doi.org/10.1046/j.1365-2265.1998.00507.x
  5. Song YD. Korean Endocrine Society. In: Texbook of Endocrinology and Metabolism. 2nd ed. Seoul: Koonja Publishing; 2011, p. 73, 265, 267-70, 282-4, 289-93.
  6. Lee JH, Kim SM, Kim HJ, Lee MJ. The Influence of Predisposing Factors and Sign of Hypoadrenia on Autonomic Nervous System Activity and Salivary Cortisol. J Oriental Rehab Med 2008;18(2):131-42.
  7. Jung JH, Choi YS, Kim JE, Kim EY. Opioids use and adrenal insufficiency. Korean J Hosp Palliat Vare 2014;17:113-21. https://doi.org/10.14475/kjhpc.2014.17.3.113
  8. Chrousos GP. Stress and disorders of the stress system. Nat Rev Endocrinol 2009;5(7):374-81. https://doi.org/10.1038/nrendo.2009.106
  9. Johnson KL, Rn CR. The hypothalamic-pituitary -adrenal axis in critical illness. AACN Clin Issues 2006;17(1):39-49. https://doi.org/10.1097/00044067-200601000-00006
  10. Jefferies WM. Cortisol and immunity. Med Hypotheses 1991;34(3):198-208. https://doi.org/10.1016/0306-9877(91)90212-H
  11. de Kloet ER. hormones, brain and stress. Endocr Regul 2003;37(2):51-68.
  12. Kirschbaum C, Hellhammer DH. Salivary cortisol in psychoneuroendocrine research: recent development and applications. Psychoneuroendocrinology 1994; 19(4):313-33. https://doi.org/10.1016/0306-4530(94)90013-2
  13. Di Luigi L, Guidetti L, Baldari C, Gallotta MC, Sgro P, Perroni F, et al. Cortisol, dehydroepiandrosterone sulphate and dehydroepiandrosterone sulphate/ cortisol ratio responses to physical stress in males are influenced by pubertal development. J Endocrinol Invest 2006;29(9):796-804. https://doi.org/10.1007/BF03347373
  14. Mommersteeg PM, Heijinen CJ, Verbraak MJ, van Doornen LJ. Clinical burnout is not reflected in the cortisol awakening response, the day-curve or the response to a low-dose dexamethasone suppression test. Psychoneuroendocrinology 2006; 31(2):216-25. https://doi.org/10.1016/j.psyneuen.2005.07.003
  15. Grossi G, Perski A, Ekstedt M, Johansson T, Lindstrom M, Holm K. The morning salivary cortisol response in burnout. J Psychosom Res 2005;59(2):103-11. https://doi.org/10.1016/j.jpsychores.2005.02.009
  16. Walther DS. Lee SW, Yoon SI. Applied Kinesiology. Goyang: Daesung publishing company; 2002, p. 673.
  17. Blum CA, Mueller C, Schuetz P, Fluri F, Trummler M, Mueller B, et al. Prognostric value of dehydroepiandrosterone-sulfate and other parameters of adrenal function in acute ischemic strke. PLoS One 2013;8e63224. https://doi.org/10.1371/journal.pone.0063224
  18. van Niekerk JK, Hupper FA, Herbert J. Salivary cortisol and DHEA: association with measures of cognition and well-being in normal older men, and effects of three months of DHEA supplementation. Psychoneuroendocrinology 2001;26:591-612. https://doi.org/10.1016/S0306-4530(01)00014-2
  19. Misra M, Miller K, Almazan C, Ramaswamy K, Aggarwal A, Herzog DB, et al. Hormonal and body composition predictors of soluble leptin recepter, leptin, and free leptin index in adolescent girls with anorexia nervosa and controls and relation to insulin sensitivity. Journal of Clinical Endocrinology and Metabolism 2004;89:3486-95. https://doi.org/10.1210/jc.2003-032251
  20. Daniell HW. DHEAS deficency during consumption of sustained-action prescribed opioids: evidence for opioid-induced inhibition of adrenal androgen production. J Pain 2006;7:901-7. https://doi.org/10.1016/j.jpain.2006.04.011
  21. Nestler JE, Barlascini CO, Clore JN, Blackard WG. Dehydroepiandrosterone reduces serum low density lipoprotein levels and body fat but does not alter insulin sensitivity in normal men. J Clin Endocrinol Metab 1988;66:57-61. https://doi.org/10.1210/jcem-66-1-57
  22. Mortola JF, Yen SSC. The effects of oral dehydroepiandrosterone on endocrine-metabolic parameters in postmenopausal women. J Clin 1990;71:696-704.
  23. Barrett-Connor E, Khaw KT, Yen SSC. A prospective study of dehydroepiandrosterone sulfate, mortality, and cardiovascular disease. N Engl J Med 1986;315:1519-24. https://doi.org/10.1056/NEJM198612113152405
  24. Slowinska-Srzedinka J, Zglicznski S, Ciswicka-Sznajderman M, Srezednicki M, Soszynski P, Biernacka M, et al. Decreased plasma dehydroepiandrosterone sulfate and dihydrotestosterone concentrations in young men after myocardial infarction. Athero 1989;79:197-203. https://doi.org/10.1016/0021-9150(89)90124-X
  25. Ahn RS, Lee YJ, Choi JY, Kwon HB, Chun SI. Salivary Cortisol and DHEA Levels in the Korean Population: Age-Related Differences, Diurnal Rhythm, and Correlations with Serum Levels. Yonsei Med J 2007;Jun;30;48(3):379-88. https://doi.org/10.3349/ymj.2007.48.3.379
  26. Orentreich N, Brind JL, Rizer RL, Vogelman JH, Andres R, Baldwin H. Long-term longitudinal measurements of plasma dehydroepiandrosterone sulfate in normal men. J Clin Endocrinol Metab 1992;75:1002-4.
  27. Birkenhager-Gillesse EG, Derksen J, Lagaay AM. Dehydroepiandrosterone sulfate(DHEAS) in the oldest old, aged 85 and over. Annals of the New York Academy of Sciences 1994;719: 543-52. https://doi.org/10.1111/j.1749-6632.1994.tb56858.x