대한한방내과학회지 (The Journal of Internal Korean Medicine)

대한한방내과학회 (The Society of Internal Korean Medicine)
권호 표지
DOI QR코드

DOI QR Code

은화연교탕(銀花連翹湯)을 투여한 기침 환자에 대한 후향적 연구

Retrospective Study of Patients with Cough Treated with Eunhwayeongyo-tang

  • 백현정 (경희대학교 한의과대학 폐계내과학교실) ;
  • 이범준 (경희대학교 한의과대학 폐계내과학교실) ;
  • 정승기 (경희대학교 한의과대학 폐계내과학교실) ;
  • 정희재 (경희대학교 한의과대학 폐계내과학교실)
  • Baek, Hyun-jung (Division of Allergy, Immune & Respiratory System, Dept. of Internal Medicine, College of Korean Medicine, Kyung-Hee University) ;
  • Lee, Beom-joon (Division of Allergy, Immune & Respiratory System, Dept. of Internal Medicine, College of Korean Medicine, Kyung-Hee University) ;
  • Jung, Sung-ki (Division of Allergy, Immune & Respiratory System, Dept. of Internal Medicine, College of Korean Medicine, Kyung-Hee University) ;
  • Jung, Hee-jae (Division of Allergy, Immune & Respiratory System, Dept. of Internal Medicine, College of Korean Medicine, Kyung-Hee University)
  • 투고 : 2016.11.02
  • 심사 : 2016.11.30
  • 발행 : 2016.12.30
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

Objectives: This study was designed to analyze the treatment effects of Eunhwayeongyo-tang through retrospective chart reviews. We also checked the correlation between each pair of variables of the symptoms and curative rates of patients with cough. Methods: Thirty-three patients with cough who had satisfied the selection criteria were retrospectively reviewed through their basic medical records, nasal endoscopy, and questionnaires about cough on their first and second visits. The questionnaires used were "The questionnaire on clinical symptoms of cough & sputum", Leicester Cough Questionnaire Korean Version (LCQ-K), Total Nasal Symptom Scores (TNSS), Visual Analog Scale (VAS), and "Cold-heat patterns". The improvement rate, calculated by "The questionnaire on clinical symptoms of cough & sputum" was considered to be clinically effective if reduction of symptoms scored more than 30%. The state of nasopharyngeal mucosa was assessed to categorize the cold-heat patterns of the upper respiratory tract and for diagnosis. Results: According to this study, cough and sputum improved by $57.22{\pm}37.76%$. Most patients (76%) improved significantly after $12.18{\pm}6.59days$ of taking Eunhwayeongyo-tang. The cure rates of 26 patients among the 33 patients were judged as effective. All the mean scores of the questionnaires and the anterior nasal cavity states were significantly improved on the patients' second visits. After $18.39{\pm}15.68days$, 30 patients were completely cured and ended treatment. The nasopharyngeal mucosa states of all patients were categorized as heat patterns. Conclusions: The conditions of the patients with nasopharyngitis significantly improved after taking Eunhwayeongyo-tang. All of the patients had pharyngitis or rhinitis. The cold-heat pattern of nasopharyngeal mucosa was a significant indicator of upper respiratory inflammation diagnosis.

키워드

참고문헌

  1. Jeongdam editorial department. Steps to Internal Medicine, pulmonology 4. Seoul: Jeongdam; 2013, p. 24-5.
  2. Andersson M, Svensson C, Andersson P, Pipkorn U. Objective monitoring of the allergic inflammatory response of the nasal mucosa in patients with hay fever during natural allergen challenge. Am Rev Respir Dis 1989;139:911-4. https://doi.org/10.1164/ajrccm/139.4.911
  3. Gong TX. (Enlargement)Man-Byeong-Hoi-Chun (volume two). Seoul: Iljungsa; 1994, p. 12-4.
  4. Jang BH, Choi IH, Kim KS, Kim HT, Kim KJ, Kim MH, et al. Current status of allergic rhinitis patients in Korean Medicine hospitals - Exploratory study based on electronic medical records of 3 hospitals. The Journal of Korean Medical Ophthalmology & Otolaryngology & Dermatology 2014;27(1):117-29. https://doi.org/10.6114/jkood.2014.27.1.117
  5. Park JH, Hong SU. The Effects of Hyunggaeyungyo-tang of Suppression of iNOS Production on Mice with Allergic Rhinitis. The Journal of Korean Oriental Medical Ophthalmology & Otolaryngology & Dermatology 2012;25(1):12-21.
  6. Shin SY. Effects of Hyunggyeyungyotang and Kamihyunggyeyungyotang administration on the anti-inflammation, analgesia and anti-allergic reaction in mice. J Pediatr Korean Med 1997; 11(1):249-73.
  7. Kyung Hee University Korean Medicine Hospital. Kyung Hee Korean Medicine Prescription. Seoul: Twin planning; 1997, p 491.
  8. Kim Y, Yang SY, Oh YS, Lee JW, Lee YK, Park YC. Research trends of Lonicera japonica over the last 10 years. Collection of dissertations: Korean medical laboratory, Daejon University 2010;19(1):17-23.
  9. Lee HB, Park EK, Baek HJ, Lee BJ, Jung SK, Jung HJ. Clinical Values of Cold-Heat Pattern Diagnosis by the Nasal Endoscopy for Patients with Cough. J. Int. Korean Med. 2014:35(3)274-87.
  10. Ministry of Food and Drug Safety, Herbal medicine Evaluation Department. Guidelines for Crude Drugs(Korean Medicine) Clinical Trial : Antitussive, Mucolytic Agents. Seoul: Ministry of Food and Drug Safety; 2008, p. 3, 5-8, 12, 15.
  11. Ministry of Food and Drug Safety. Research on outcome indicators for clinical trials of herbal medicinal products. Seoul: Ministry of Food and Drug Safety; 2006, p. 84-88.
  12. Miyamoto T, Inoue H, Kitamura S, Yamamoto M, Yamakido M, Nagano Q, et al. Effect of TSUMURA Sho-seiryu-to (TJ-19) on bronchitis in a double-blind placebo-controlled study. J Clin Ther Med 2001;17:1189-214.
  13. Jeong DJ, Joe HM, Lim WK. Korean medicinal Endoscopy. Daejeon: Joomin; 2008, p. 6, 16-9, 20-5.
  14. Yun YH, Park JS, Kim KS, Kim NK, Kim KJ Kim HT, et al. A Study on the Development of Guideline for Assessing Anterior Nasal Cavity Using Nasal Endoscopy on Allergic Rhinitis Patients. Journal of Society of Preventive Korean Medicine 2013;17(1):199-207.
  15. Han JM, Jung IC, Kang W, Kim SS, Yeo Y, Park YC. Reliability and validity of Leicester Cough Questionnaire Korean version. Chron Respir Dis 2014;11(3):147-52. https://doi.org/10.1177/1479972314536206
  16. French CL, Irwin RS, Curley FJ, Krikorian CJ. Impact of chronic cough on quality of life. Arch Intern Med 1998;158(15):1657-61. https://doi.org/10.1001/archinte.158.15.1657
  17. Spinou A, Birring SS. An update on measurement and monitoring of cough: what are the important study endpoints?. J Thorac Dis 2014;6(S7): S728-S734.
  18. Adamopoulos G, Manolopoulos L, Giotakis I. A comparison of the efficacy and patient acceptability of budesonide and beclomethasone dipropionate aqueous nasal sprays in patients with perennial rhinitis. Clin Otolaryngol 1995;20(4):340-4. https://doi.org/10.1111/j.1365-2273.1995.tb00055.x
  19. Ryu HH, Lee HJ, Kim HG, Kim JY. Reliability and validity of a cold heat pattern questionnaire for traditional chinese medicine. J Altern Complement Med 2010;16(6):663-7. https://doi.org/10.1089/acm.2009.0331
  20. Kim SK, Park YB. Development of Questionnarire for Cold-Heat Patternization. The Journal of the Society of Korean Medicine Diagnostics 2003;7(1):64-75.
  21. An JE, Yu LY, Lee JH. Medical.Public Health Statistical Analysis. Seoul: KoRyeo Information Industry; 2000, p. 261-423.
  22. Chung KF. Approach to chronic cough : the neuropathic basis for cough hypersensitivity syndrome. J Thorac Dis 2014;6(Suppl 7):S699-707.
  23. Kim HJ. Current clinical practice for wintertime common cold. J Int Korean Med 2009;76(1): 30-2.
  24. KAPHD. KAPHD's manual for public health doctor. Paju: Wendseday; 2011, p. 159.
  25. Kim CW. Airway disorders associated with chronic cough. J Int Korean Med 2010;78(6):665-9.
  26. Polosa R, Ciamarra I, Mangano G, Prosperini G, Pistorio MP, Vancheri C, et al. Bronchial hyperresponsiveness and airwayinflammation markers in nonasthmatics with allergic rhinitis. Eur Respir J 2000;15:30-5. https://doi.org/10.1183/09031936.00.15103000
  27. Slavin RG. The upper and lower airways: the epidemiological and pathophysiological connection. Allergy Asthma Proc 2008;29:553. https://doi.org/10.2500/aap.2008.29.3169
  28. Boulet LP. Physiopathology of Airway Hyperresponsiveness. Current Allergy and Asthma Reports. 2003;3(2):166-71. https://doi.org/10.1007/s11882-003-0030-9
  29. Shin JY. Bang-Yak-Hap-Pyun Explanation. Seoul: Sin Gwang Mun Hwa Sa; 1989, p. 169.
  30. Blom HM, Godthelp T, Fokkens WJ, Klein Jan A, Holm AF, Vroom TM, et al. Mast cells, eosinophils and IgE-positive cells in the nasal mucosa of patients with vasomotor rhinitis. Eur Arch Otorhinolaryngol 1995;252(1):33-9. https://doi.org/10.1007/BF02484432
  31. Powe DG, Huskisson RS, Carney AS, Jenkins D, Jones NS. Evidence for an inflammatory pathophysiology in idiopathic rhinitis. Clin Exp Allergy 2001;31:864. https://doi.org/10.1046/j.1365-2222.2001.01106.x
  32. Srivastava K, Zhang T, Yang N, Sampson H, Li XM. Anti-asthma simplified herbal medicine intervention induced long-lasting tolerance to allergen exposure in an asthma model is interferon-gamma, but not transforming growth factor-beta dependent. Clin Exp Allergy 2010; 40(11):1678-88. https://doi.org/10.1111/j.1365-2222.2010.03545.x
  33. Jian WY. Therapeutic wisdom in traditional chinese medicine: a perspective from modern science. Discov Med 2005;5(29):455-61.
  34. Bae NS, Park YJ, Oh HS, Park YB. Preceding Studies for Questionnaires on Han-Yol Patternization. J Korean Orient Med Diagn 2005;9(1):98-111.
  35. Kim DH, Lee JH. Yellow Emperor's Inner Canon(volume one). Seoul: Eui Seong Dang; 2001, p. 726.
  36. Byun YS, Yang SY, Jeong IC, Hong KE, Kang WC, Yeoe Y, Park YC. Effects of So-cheong-ryong-tang and Yeon-gyo-pae-dok-san on the common cold: Randomized, double blind, placebo controlled trial. J Ethnopharmacol 2011;133(2): 642-6. https://doi.org/10.1016/j.jep.2010.10.056
  37. Wong W, Lam CL, Fong DY. Treatment effectiveness of two Chinese herbal medicine formulae in upper respiratory tract infections-a randomized double-blind placebo-controlled trial. Fam Pract 2012;29(6):643-52. https://doi.org/10.1093/fampra/cms027

피인용 문헌

  1. 도적강기탕(導赤降氣湯)을 투여한 급성기관지염 치험 3례 vol.39, pp.5, 2016, https://doi.org/10.22246/jikm.2018.39.5.1068