Journal of The Korean Society of Clinical Toxicology (대한임상독성학회지)

Korean society of Clincal Toxicology (대한임상독성학회)
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Utility of the APACHE II Score as a Neurologic Prognostic Factor for Glufosinate Intoxicated Patients

Glufosinate 중독 환자의 신경학적 예후 인자로서 APACHE II Score의 유용성

  • Yoo, Dae Han (Department of Emergency Medicine, College of Medicine, Soonchunhyang University) ;
  • Lee, Jung Won (Department of Emergency Medicine, College of Medicine, Soonchunhyang University) ;
  • Choi, Jae Hyung (Department of Emergency Medicine, College of Medicine, Soonchunhyang University) ;
  • Jeong, Dong Kil (Department of Emergency Medicine, College of Medicine, Soonchunhyang University) ;
  • Lee, Dong Wook (Department of Emergency Medicine, College of Medicine, Soonchunhyang University) ;
  • Lee, Young Joo (Department of Emergency Medicine, College of Medicine, Soonchunhyang University) ;
  • Cho, Young Shin (Department of Emergency Medicine, College of Medicine, Soonchunhyang University) ;
  • Park, Joon Bum (Department of Emergency Medicine, College of Medicine, Soonchunhyang University) ;
  • Chung, Hae Jin (Department of Emergency Medicine, College of Medicine, Soonchunhyang University) ;
  • Moon, Hyung Jun (Department of Emergency Medicine, College of Medicine, Soonchunhyang University)
  • 유대한 (순천향대학교 의과대학 응급의학교실) ;
  • 이정원 (순천향대학교 의과대학 응급의학교실) ;
  • 최재형 (순천향대학교 의과대학 응급의학교실) ;
  • 정동길 (순천향대학교 의과대학 응급의학교실) ;
  • 이동욱 (순천향대학교 의과대학 응급의학교실) ;
  • 이영주 (순천향대학교 의과대학 응급의학교실) ;
  • 조영신 (순천향대학교 의과대학 응급의학교실) ;
  • 박준범 (순천향대학교 의과대학 응급의학교실) ;
  • 정혜진 (순천향대학교 의과대학 응급의학교실) ;
  • 문형준 (순천향대학교 의과대학 응급의학교실)
  • Received : 2016.06.28
  • Accepted : 2016.09.25
  • Published : 2016.12.31
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Abstract

Purpose: The incidence of glufosinate poisoning is gradually increasing, and it can be fatal if severe poisoning occurs. However, factors useful for predicting the post-discharge neurological prognosis of patients who have ingested glufosinate have yet to be identified. Our objective was to evaluate the utility of the acute physiology and chronic health evaluation (APACHE) II score measured in the emergency department for predicting the neurological prognosis. Methods: From April 2012 to August 2014, we conducted a retrospective study of patients who had ingested glufosinate. The outcome of the patients at discharge was defined by the Cerebral Performance Category Score (CPC). The patients were divided into a good prognosis group (CPC 1, 2) and a poor prognosis group (CPC 3, 4, 5), after which the APACHE II scores were compared. The Hosmer-Lemeshow test and the area under the receiver operating characteristic (ROC) curve from patients determined calibration and discrimination. Results: A total of 76 patients were enrolled (good prognosis group: 67 vs poor prognosis group: 9). The cut-off value for the APACHE II score was 12 and the area under the curve value was 0.891. The Hosmer and Lemeshow C statistic x2 was 7.414 (p=0.387), indicating good calibration for APACHE II. Conclusion: The APACHE II score is useful at predicting the neurological prognosis of patients who have ingested glufosinate.

Keywords

References

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