농약과학회지 (The Korean Journal of Pesticide Science)

  • 제20권4호
  • /
  • Pages.326-340
  • /
  • 2016
  • /
  • 1226-6183(pISSN)
  • /
  • 2287-2051(eISSN)
한국농약과학회 (The Korean Society of Pesticide Science)
권호 표지
DOI QR코드

DOI QR Code

농약 품목에 대한 GHS 기준과 농진청 기준에 따른 자극성 산출 후 자극성 분류 차이 비교

Comparison of Differences between the Results of Irritation Classification after Irritation Calculation with GHS Criteria and RDA Directives in Plant Protection Products

  • 유아선 (국립농업과학원 농산물안전성부 농자재평가과) ;
  • 오진아 (국립농업과학원 농산물안전성부 농자재평가과) ;
  • 박수진 (국립농업과학원 농산물안전성부 농자재평가과) ;
  • 조유미 (국립농업과학원 농산물안전성부 농자재평가과) ;
  • 이제봉 (국립농업과학원 농산물안전성부 농자재평가과) ;
  • 이난희 (국립농업과학원 농산물안전성부 농자재평가과) ;
  • 이주연 (국립농업과학원 농산물안전성부 농자재평가과) ;
  • 임양빈 (국립농업과학원 농산물안전성부 농자재평가과)
  • You, Are-Sun (Division of Agro-material Safety Evaluation, Department of Agro-food Safety, National Institute of Agricultural Sciences) ;
  • Oh, Jin A (Division of Agro-material Safety Evaluation, Department of Agro-food Safety, National Institute of Agricultural Sciences) ;
  • Park, Soojin (Division of Agro-material Safety Evaluation, Department of Agro-food Safety, National Institute of Agricultural Sciences) ;
  • Jo, Youmi (Division of Agro-material Safety Evaluation, Department of Agro-food Safety, National Institute of Agricultural Sciences) ;
  • Lee, Je Bong (Division of Agro-material Safety Evaluation, Department of Agro-food Safety, National Institute of Agricultural Sciences) ;
  • Lee, Nanhee (Division of Agro-material Safety Evaluation, Department of Agro-food Safety, National Institute of Agricultural Sciences) ;
  • Lee, Ju Yeon (Division of Agro-material Safety Evaluation, Department of Agro-food Safety, National Institute of Agricultural Sciences) ;
  • Ihm, Yangbin (Division of Agro-material Safety Evaluation, Department of Agro-food Safety, National Institute of Agricultural Sciences)
  • 투고 : 2016.10.25
  • 심사 : 2016.11.29
  • 발행 : 2016.12.31
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

농약의 원제에 대한 GHS 체계 도입에 따라 농약 품목에 대한 GHS 도입 필요성이 대두되고 있어 GHS 도입 시 현행과의 평가 기준을 비교하였다. 농약 59 품목의 독성시험성적에 대하여 농약관리법과 GHS에 따라 피부자극성 및 안점막자극성을 산출 및 분류한 결과, 피부자극성 경도 및 중도로 분류된 품목에서 GHS 기준에 의해 '분류되지 않음'으로 구분된 품목이 전체의 25.5%였고 안점막자극성 경도에서 GHS 기준에 의해 '분류되지 않음'으로 구분된 품목이 45.8%로 나타나 자극성 구분이 완화되었다. 반면 비가역적 반응의 평가에 의해 경도와 중도에서 피부자극성이 피부부식성 구분 1로 보다 높게 평가된 품목이 6.8%, 안점막자극성이 심한 눈손상 구분 1로 보다 높게 평가 된 품목이 5.1%였다. 농약 품목의 시험성적을 이용한 GHS 분류와 품목에 함유된 원제의 자극성 구분과 함유량을 이용하여 GHS 혼합물 분류기준에 따라 분류한 결과를 비교한 결과, 피부자극성에서는 25.5% 품목의 자극성 구분이 완화되었고, 3.4% 품목의 자극성 구분이 강화되었다. 안점막자극성에서는 25.4%의 품목에 대한 자극성 구분이 완화되었고 11.9%의 품목의 자극성 구분이 강화되었다. 농약 품목에 GHS를 도입할 경우, 상이한 분류 결과를 보완할 수 있는 방안 마련이 필요하다고 사료된다.

GHS was compared with that of current RDA directives in skin and eye irritation for plant protection products (PPPs). According to the result of evaluation and classification of skin and eye irritation by RDA directives and GHS for 59 PPPs, 25.5% of PPPs were changed the classification of skin irritation from slightly and moderately by RDA directives to Not Classified by GHS, and 45.8% of PPPs were changed the classification of eye irritation from slightly by RDA directives to Not Classified by GHS. 6.8% of PPPs in skin irritation and 5.1% in eye irritation were classified more highly as category 1 by GHS because of irreversible effect. According to the result of comparison with GHS classification by data of irritation study for PPPs and by GHS classification and concentration of active substances, 25.5% was changed more lowly and 3.4% more highly in skin irritation, and 25.4% was changed more lowly and 11.9% more highly in eye irritation. It is needed to draw a plan to supplement for other results between GHS and RDA directives.

키워드

참고문헌

  1. European commission (2009) Classification, labelling, and Packaging Regulation No. 1272/2009
  2. European Crop Protection (2015), Classification and Labelling of Plant Protection Products, http://www.ecpa.eu/industryresources/classification-and-labelling-plant-protectionproducts
  3. Government combination committee for development of GHS (2009) Globally harmonized system of classification and labelling for chemicals (GHS), Government combination committee for development of GHS, UN edition, 2009
  4. Hill R. H. (2010) GHS and its impact on laboratory safety, Journal of Chemical Health & Safety, July/August, pp. 5-11
  5. Jonai H. (2008) Implementation of GHS in Japan, Ind Health 46:443-7 https://doi.org/10.2486/indhealth.46.443
  6. ME (2012) Regulation for classification and labelling of hazardous chemical, NIER directives, 2012-8
  7. MOEL (2012) Criteria for Classification and labelling of Chemical and MSDS, MOEL directives, 2012-14
  8. Morita T. and Morikawa K. (2011) Expert review for GHS Classification fo chemicals on health effects, Industrial Health, 49:559-565 https://doi.org/10.2486/indhealth.MS1267
  9. NEMA (2008) Criteria for classification and labelling of hazardous substances, NEMA directives, 2008-13
  10. Occupational Safety and Health Administration (2006) Advanced notice of proposed rule making; Hazard communication, Accessed on 5/12/2009 at http://www.osha.gov/pls/oshaweb/owadisp.show_document?p_table=FEDERAL_REGISTER&p_id=18890
  11. Occupational Safety and Health Administration (2009) GHSOSHA HCS comparison. Comparison of hazard communication requirements. Accessed on 5/13/2009 at http://www.osha.gov/dsg/hazcom/GHSOSHA/ Comparison.html
  12. RDA, Agro-Material industry Division (2015a) Criteria for registration of pesticides and active substances, Legislation and Notification.Directive for pesticide regulation, RDA, 239-240
  13. RDA, Agro-Material industry Division (2015b) Criteria for registration of pesticides and active substances, Legislation and Notification.Directive for pesticide regulation, RDA, 245
  14. RDA, Agro-Material industry Division (2015c) Criteria for registration of pesticides and active substances, Legislation and Notification.Directive for pesticide regulation, RDA, 332-335
  15. RDA, Agro-Material industry Division (2015d) Enforcement ordinance, attach 2 in legislation for pesticide regulation, Legislation and Notification.Directive for pesticide regulation, RDA, 157
  16. RDA, Agro-Material industry Division (2015e) Labelling criteria for pesticides, active substances, and appliance with pesticides in legislation for pesticide regulation, Legislation and Notification.Directive for pesticide regulation, RDA, pp. 655-711
  17. Seguin, L. (2009) Optimizing your company's GHS deployment, J. Chem. Health. Saf., 16(4):5-9 https://doi.org/10.1016/j.jchas.2008.10.001
  18. Ta, G.C., Mokhtar, M. B., Peterson, P.J., Yahaya, N (2011) A Comparison of Mandatory and Voluntary Approaches to the Implementation of Globally Harmonized System of Classification and Labelling of Chemicals (GHS) in the Management of Hazardous Chemicals, Industrial health 49(6):765-773 https://doi.org/10.2486/indhealth.MS1258
  19. United Nations (1992) Agenda 21, United Nations, New York
  20. United Nations Institute for Training and Research (2005) Developing a national GHS implementation strategy: a guidance document to support implementation of the GHS. UNITAR, Geneva
  21. United Nations Economic Commission for Europe (2009) Globally Harmonized System for Classification and Labeling of Chemicals, Historical background, Accessed on 5/6/2009 at http://www.unece.org/trans/danger/publi/ghs/histback_e.html
  22. United Nations (2011) Globally Harmonized System of Classification and Labelling of Chemicals (GHS), fourth revised edition, UN, ST/SG/AC.10/30/Rev.4
  23. United Nations (2015) Globally Harmonized System of Classification and Labelling of Chemicals (GHS), Sixth revised edition, UN, ST/SG/AC.10/30/Rev.6

피인용 문헌

  1. Assessment of the Ocular Irritation Potential of Pesticides using Reconstructed Human Cornea-like Epithelium (RhCE) Model as Alternatives to Animal Testing vol.22, pp.3, 2018, https://doi.org/10.7585/kjps.2018.22.3.216