Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
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Inhibitory Effects of Albizziae Cortex Extracts on Adipocyte Differentiation

합환피 추출물의 지방세포 분화 억제 효과

  • Lee, Su Ho (Department of Physiology, School of Korean Medicine, Wonkwang University) ;
  • Lee, Young Rae (Department of Oral Biochemistry, School of Dentistry, Wonkwang University) ;
  • Ryu, Do Gon (Department of Physiology, School of Korean Medicine, Wonkwang University) ;
  • Kim, Ha Rim (Center for Metabolic Function Regulation, School of Medicine, Wonkwang University) ;
  • Kim, Mi Seong (Center for Metabolic Function Regulation, School of Medicine, Wonkwang University) ;
  • Kim, Byung Sook (Department of Hotel Culinary Arts & Nutrition, Jeonbuk Science College) ;
  • Kwon, Kang Beom (Department of Physiology, School of Korean Medicine, Wonkwang University)
  • 이수호 (원광대학교 한의과대학 생리학교실) ;
  • 이영래 (원광대학교 치과대학 구강생화학교실) ;
  • 류도곤 (원광대학교 한의과대학 생리학교실) ;
  • 김하림 (원광대학교 의과대학 대사기능제어연구센터) ;
  • 김미성 (원광대학교 의과대학 대사기능제어연구센터) ;
  • 김병숙 (전북과학대학교 호텔조리영양과) ;
  • 권강범 (원광대학교 한의과대학 생리학교실)
  • Received : 2016.11.29
  • Accepted : 2016.12.21
  • Published : 2016.12.25
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Abstract

In this study, Albizziae Cortex extracts (ACE) have potent effects on adipogenesis and on lipolysis in OP9 cells. There was no cytotoxicity while cells were treated with ACE in designated time intervals, unaffected by various concentrations. In the cells with ACE-treated, increases in fat storage were inhibited, and also confirmed by Oil red O. To understand the underlying mechanism at the molecular level, the effects of ACE were examined on the expression of the genes involved in adipogenesis by using real-time PCR. In this cell model, the mRNA level of adipogenic genes such as peroxisome-proliferator-activated receptors gamma ($PPAR{\gamma}$) and CAAAT/enhancer binding protein alpha ($C/EBP{\alpha}$) were decreased by ACE treatment, comparing with those of control group. Collectively, our data suggest that ACE may have great potential as a novel anti-obesity agent.

Keywords

References

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