Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
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Melanogenic Effect of Eclipta Prostrata (L.) L.

한련초의 멜라닌합성 촉진 효과

  • Cha, Su Bin (Department of Herbal Resources, Professional Graduate School of Korean Medicine, Wonkwang University) ;
  • Park, In Hae (Department of Ophthalmology, Otolaryngology and Dermatology of Korean Medicine, College of Korean Medicine, Wonkwang University) ;
  • Hong, Seok Hun (Department of Ophthalmology, Otolaryngology and Dermatology of Korean Medicine, College of Korean Medicine, Wonkwang University) ;
  • Mun, Yeun Ja (Department of Herbal Resources, Professional Graduate School of Korean Medicine, Wonkwang University) ;
  • Woo, Won Hong (Department of Anatomy, College of Korean Medicine, Wonkwang University)
  • 차수빈 (원광대학교 한의학전문대학원 한약자원개발학과) ;
  • 박인해 (원광대학교 한의과대학 안이비인후피부과학교실) ;
  • 홍석훈 (원광대학교 한의과대학 안이비인후피부과학교실) ;
  • 문연자 (원광대학교 한의학전문대학원 한약자원개발학과) ;
  • 우원홍 (원광대학교 한의과대학 해부학교실)
  • Received : 2016.09.30
  • Accepted : 2016.11.27
  • Published : 2016.12.25
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Abstract

This study was peformed to investigate the mechanism of ethanol extract of Eclipta Prostrata (L.) L. (EEP) induced melanogenesis. EEP enhanced tyrosinase activity and melanin contents of B16F10 cells. Moreover, EEP increased the protein expression of tyrosinase and tyrosinase-related protein 1 (TRP-1). But EEP did not increase the protein expression of tyrosinase-related protein 2 (TRP-2). These results suggest that melanogenesis-promoting effect of EEP was involved in regulation of tyrosinaase and TRP-1 protein, and EEP may be a potent pigmentation darkening agent in hypopigmentation condition.

Keywords

References

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