Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
권호 표지
DOI QR코드

DOI QR Code

Review of Network Pharmacological Approaches on Korean Medicine

네크워크 약리학적 방법론을 활용한 한의학 효능 연구 고찰

  • Beck, Jong Min (Division of Longevity and Biofunctional Medicine, School of Korean Medicine, Pusan National University) ;
  • Seo, Han Kil (Division of Longevity and Biofunctional Medicine, School of Korean Medicine, Pusan National University) ;
  • Kwon, Young Kyu (Division of Longevity and Biofunctional Medicine, School of Korean Medicine, Pusan National University)
  • 백종민 (부산대학교 한의학전문대학원 양생기능의학부) ;
  • 서한길 (부산대학교 한의학전문대학원 양생기능의학부) ;
  • 권영규 (부산대학교 한의학전문대학원 양생기능의학부)
  • Received : 2016.11.30
  • Accepted : 2016.12.19
  • Published : 2016.12.25
Download PDF
⟨ Previous Next ⟩

Abstract

This study analyzed research methodologies based on network pharmacology to build a new system architecture optimized for Korean Medicine research. Results form studies using network pharmacology were collected and analyzed to evaluate the strength and weakness. Finally, an improved system architecture was proposed. Whether the predicted effects of drugs or herbs from network pharmacological analyses were in agreement with those from conventioanl knowledge of Korean Medicine was evaluated. These results were used to verify the applicability of research methodologies to the modern pharmacology and Korean Medicine respectively. Eighteen papers using TCMSP were collected and analyzed. The results suggest that the research methodology based on network pharmacology is appropriate only for the modern pharmacology but not for Korean Medicine. Information about compound-compound, herb-herb and drug-compound interactions need to be considered. We propose the modified system architecture with those information.

Keywords

References

  1. Li, S. Network systems underlying traditional Chinese medicine syndrome and herbformula. Current Bioinformatics. 4(9):188-196, 2009. https://doi.org/10.2174/157489309789071129
  2. Jia, W., Gao, W.Y., Yan, Y.Q., Wang, J., Xu, Z.H., Zheng, W.J., Xiao, P.G. The rediscovery of ancient Chinese herbal formulas. Phyto therapy Research. 18: 681-686, 2004. https://doi.org/10.1002/ptr.1506
  3. Lin, T.X., Li, Y.H. Discussion on the three levels of the prescription-composition principle of TCM. Deutsche Zeitschrift fur Akupunktur. 52: 27-30, 2009. https://doi.org/10.1016/j.dza.2009.05.008
  4. Tang, F., Zhang, Q., Nie, Z., Yao, S., Chen, B. Sample preparation for analyzing traditional Chinese medicines. TrAC Trends in Analytical Chemistry. 28: 1253-1262, 2009. https://doi.org/10.1016/j.trac.2009.09.004
  5. Gu, J.Y., Yuan, G., Zhu, Y.H., Xu, X.J. Computational pharmacological studies on cardiovascular disease by Qishen Yiqi Diwan. Science in China Series B:Chemistry. 52: 1871-1878, 2009.
  6. Zhao, J., Jiang, P., Zhang, W. Molecular networks for the study of TCM pharmacology. Briefings in Bioinformatics. 11: 417-430, 2010. https://doi.org/10.1093/bib/bbp063
  7. Li, P., Yang, L.P., Gong, Y.W. Application of systems biology technology in research of traditional Chinese medicine. Journal of Traditional Chinese Medicine. 2: 153-157, 2009.
  8. Ru, J., Li, P., Wang, J., Zhou, W., Li, B., Huang, C., Yang, L. TCMSP: a database of systems pharmacology for drug discovery from herbal medicines. J. Cheminformatics, 6(1):13, 2014. https://doi.org/10.1186/1758-2946-6-13
  9. Ji, Z.L., Zhou, H., Wang, J.F. Traditional Chinese medicine information database [J]. J Ethnopharmacol, 103(3):501, 2006. https://doi.org/10.1016/j.jep.2005.11.003
  10. Chen, C.Y. TCM Database@Taiwan: the world's largest traditional Chinese medicine database for drug screening in silico. PLoS One, 6(1):e15939, 2011. https://doi.org/10.1371/journal.pone.0015939
  11. Fang, Y.C., Huang, H.C., Chen, H.H. TCMGeneDIT: a database for associated traditional Chinese medicine, gene and disease information using text mining. BMC Complement Altern Med. 8: 58, 2008. https://doi.org/10.1186/1472-6882-8-58
  12. Fang, X., Shao, L., Zhang, H. CHMIS-C: a comprehensive herbal medicine information system for cancer. J Med Chem, 48(5):1481-1488, 2005. https://doi.org/10.1021/jm049838d
  13. Xue, R., Fang, Z., Zhang, M. TCMID: Traditional Chinese Medicine integrative database for herb molecular mechanism analysis [J]. Nucleic Acids Res, 41: D1089-D1095, 2013. https://doi.org/10.1093/nar/gks1100
  14. Ehrman, T.M., Barlow, D.J., Hylands, P.J. Phytochemical databases of Chinese herbal constituents and bioactive plant compounds with known target specificities. Journal of chemical information and modeling. 47(2):254-263, 2007. https://doi.org/10.1021/ci600288m
  15. Ye, H., Ye, L., Kang, H., Zhang, D., Tao, L., Tang, K., Cao, Z. HIT: linking herbal active ingredients to targets. Nucleic acids research, 39(suppl 1):D1055-D1059, 2011. https://doi.org/10.1093/nar/gkq1165
  16. Li, J., Zhao, P., Li, Y., Tian, Y., Wang, Y. Systems pharmacology-based dissection of mechanisms of Chinese medicinal formula Bufei Yishen as an effective treatment for chronic obstructive pulmonary disease. Sci Rep. 5:15290. doi:10.1038/srep15290, 2015.
  17. Li, Y., Wang, J., Xiao, Y., Wang, Y., Chen, S., Yang, Y., Lu, A., Zhang, S. A Systems pharmacology approach to investigate the Mechanisms of action of semen Strychni and Tripterygium wilfordii Hook F for treatment of rheumatoid arthritis. J Ethnopharmacol. pii:S0378-8741(15)30140-9. doi:10.1016/j.jep.2015.09.016, 2015.
  18. Li, Y., Zhang, J., Zhang, L., Chen, X., Pan, Y., Chen, S.S., Zhang, S., Wang, Z.Z., Xiao, W., Yang, L., Wang, Y. Systems pharmacology to decipher the combinational anti-migraine effects of Tianshu formula. J Ethnopharmacol. pii: S0378-8741(15)30056-8. doi:10.1016/j.jep.2015.07.043, 2015.
  19. Wang, Y.H., Zheng, C., Huang, C., Chen, X.T., Wu, Z.Y., Wang, Z.D., Xiao, W., Zhang, B., Li, Y. Systems-Pharmacology Dissecting Holistic medicine for Treatment of Complex Diseases: an example using cardio-cerebrovascular diseases treated by TCM. Evidence-Based Complementary and Alternative Medicine, 2015.
  20. Fu, Y., Wang, Y., Zhang, B. Systems pharmacology for traditional Chinese medicine with application to cardio-cerebrovascular diseases. Journal of Traditional Chinese Medical Sciences. 1(2):84-91, 2015. https://doi.org/10.1016/j.jtcms.2014.09.006
  21. Zheng, C., Guo, Z., Huang, C., Wu, Z., Li, Y., Chen, X., Fu, Y., Ru, J., Ali, S., Wang, Y., Wang, Y. Large-scale Direct Targeting for Drug Repositioning and Discovery. Scientific Reports. 5:11970. doi:10.1038/srep11970, 2015.
  22. Zhang, J., LI, Y., Chen, S. Zhang, L., Wang, J., Yang, Y., Zhang, S., Pan, Y., Yang, L., Wang, Y. Systems Pharmacology Dissection of the Anti-Inflammatory Mechanism for the Medicinal Herb Folium Eriobotryae. Int J Mol Sci. 16(2):2913-41. doi:10.3390/ijms16022913, 2015.
  23. Zhang, J., Li, Y., Chen, X., Pan, Y., Zhang, S., Wang, Y. Systems pharmacology dissection of multi-scale mechanisms of action for herbal medicines in stroke treatment and prevention. PLoS One. 9(8):e102506, 2014. https://doi.org/10.1371/journal.pone.0102506
  24. Li, B., Tao, W., Zheng, C., Piar, A.S., Huang, C., Fu, Y., Wang, Y. Systems pharmacology-based approach for dissecting the addition and subtraction theory of traditional Chinese medicine - An example using Xiao-Chaihu-Decoction and Da-Chaihu-Decoction. Computers in Biology and Medicine, 53: 19-29, 2014. https://doi.org/10.1016/j.compbiomed.2014.05.007
  25. Zheng, C., Wang, J., Liu, J., Pei, M., Huang, C., Wang, Y. Systems-level Multi-target Drug Discovery from Natural Products with Applications to Cardiovascular Diseases. J Ethnopharmacol. 151(1):93-107, 2014. https://doi.org/10.1016/j.jep.2013.07.001
  26. Zhou, W., Wang, Y. A network-based analysis of the types of coronary artery disease from traditional Chinese medicine perspective: Potential for therapeutics anddrug discovery. Journal of Ethnopharmacology, 2013.
  27. Liu, J., Pei, M., Zheng, C., Li, Y., Wang, Y., Lu, A., Yang, L. A systems-pharmacology analysis of herbal medicines used in health improvement treatment: predicting potential new drugs and targets. Evid Based Complement Alternat Med. doi:10.1155/2013/938764, 2013.
  28. Li, P., Chen, J., Wang, J., Zhou, W., Wang, X., Li, B., Tao, W., Wang, W., Wang, Y., Yang, L. Systems pharmacology strategies for Drug Discovery and Combination with applications to cardiovascular diseases. Journal of Ethnopharmacology, 2013.
  29. Yao, Y., Zhang, X., Wang, Z., Zheng, C., Li, P., Huang, C., Tao, W., Xiao, W., Wang, Y., Huang, L., Yang, L., Deciphering the combination principles of Traditional ChineseMedicine from a Systems Pharmacology perspective. J Ethnopharmacol. 150(2):619-638, 2013. https://doi.org/10.1016/j.jep.2013.09.018
  30. Huang, C., Zheng, C., Li, Y., Wang, Y., Lu, A., Yang, L., Systems Pharmacology in DrugDiscovery and Therapeutic Insight for Herbal Medicines. Brief Bioinform. 15(5):710-733, 2013. https://doi.org/10.1093/bib/bbt035
  31. Liu, H., Wang, J., Zhou, W., Wang, Y., Yang, L., Systems Approaches and Polypharmacology for Drug Discovery from Herbal Medicines: An Example Using Licorice. Journal ofEthnopharmacology. 146(3):773-793, 2013. https://doi.org/10.1016/j.jep.2013.02.004
  32. Wang, X., Xu, X., Li, Y., Li, X., Tao, W., Li, B., Wang, Y., Yang, L. Systems pharmacology uncovers Janus functions of botanical drugs: activation of hostdefense system and inhibition of influenza virus replication. IntegrativeBiology. 5(2):351-371, 2013.
  33. Li, B., Xu, X., Wang, X., Yu, H., Li, X., Tao, W., Wang, Y., Yang, L. A systems biology approach to understanding the mechanisms of action of Chinese herbs fortreatment of cardiovascular disease. IntJMolSci. 13(10):13501-13520, 2012.
  34. Wang, X., Xu, X., Tao, W., Li, Y., Wang, Y., Yang, L. A systems biology approach to uncover pharmacological synergy in herbal medicines with applications to cardiovascular disease. Evidence-Based Complementary andAlternative Medicine, 2012.
  35. Ru, J., Li, P., Wang, J., Zhou, W., Li, B., Huang, C., Li, P., Guo, Z., Tao, W., Yang, Y., Xu, X., Li, Y., Wang, Y., Yang, L. TCMSP: a database of systems pharmacology for drug discovery from herbal medicines. Journal of Cheminformatics. 6(1):13, 2014. https://doi.org/10.1186/1758-2946-6-13
  36. Tao, W., Xu, X., Wang, X., Li, B., Wang, Y., Li, Y., Yang, L., Network pharmacology-based prediction of the active ingredients and potential targetsof Chinese herbal Radix Curcumae formula for application to cardiovasculardisease. Journal of Ethnopharmacology. 145(1):1-10, 2013. https://doi.org/10.1016/j.jep.2012.09.051
  37. GU, L.L., WU, L.L., LI, Xiang, CHEN. J.W., LI, M. Analysis of naphtha in Semen Persicae, Flos carthami and its couplet medicines by GC-MS. Chinese Traditional Patent Medicine, 30(5):719-722, 2008.
  38. Teng, J.L. Theoretical and Experimental Studies of Huang Qi Combined With Dang Gui on the Fanction of Tonifying Qi and Activating Blood Circalation. Shandong University of Traditional Chinese Medicine. Chinese pharmacy. Doctorate. 2002.