Natural Product Sciences

The Korean Society of Pharmacognosy (한국생약학회)
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Effects of (-)-Sesamin on Memory Deficits in MPTP-lesioned Mouse Model of Parkinson's Disease

  • Zhao, Ting Ting (Department of Pharmacy and Research Center for Bioresource and Health, College of Pharmacy, Chungbuk National University) ;
  • Shin, Keon Sung (Department of Pharmacy and Research Center for Bioresource and Health, College of Pharmacy, Chungbuk National University) ;
  • Lee, Myung Koo (Department of Pharmacy and Research Center for Bioresource and Health, College of Pharmacy, Chungbuk National University)
  • Received : 2016.03.03
  • Accepted : 2016.06.10
  • Published : 2016.12.31
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Abstract

This study investigated the effects of (-)-sesamin on memory deficits in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-lesioned mouse model of Parkinson's disease (PD). MPTP lesion (30 mg/kg/day, 5 days) in mice showed memory deficits including habit learning memory and spatial memory. However, treatment with (-)-sesamin (25 and 50 mg/kg) for 21 days ameliorated memory deficits in MPTP-lesioned mouse model of PD: (-)-sesamin at both doses improved decreases in the retention latency time of the passive avoidance test and the levels of dopamine, norepinephrine, 3,4-dihydroxyphenylacetic acid, and homovanillic acid, improved the decreased transfer latency time of the elevated plus-maze test, reduced the increased expression of N-methyl-D-aspartate (NMDA) receptor, and increased the reduced phosphorylation of extracellular signal-regulated kinase (ERK1/2) and cyclic AMP-response element binding protein (CREB). These results suggest that (-)-sesamin has protective effects on both habit learning memory and spatial memory deficits via the dopaminergic neurons and NMDA receptor-ERK1/2-CREB system in MPTP-lesioned mouse model of PD, respectively. Therefore, (-)-sesamin may serve as an adjuvant phytonutrient for memory deficits in PD patients.

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