Natural Product Sciences

The Korean Society of Pharmacognosy (한국생약학회)
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Anticholinesterase and Anti-inflammatory Constituents from Beilschmiedia pulverulenta Kosterm

  • Wan Salleh, Wan Mohd Nuzul Hakimi (Department of Chemistry, Faculty of Science, University, Teknologi Malaysia (UTM)) ;
  • Ahmad, Farediah (Department of Chemistry, Faculty of Science, University, Teknologi Malaysia (UTM)) ;
  • Yen, Khong Heng (School of Chemistry and Environment Studies, Faculty of Applied Sciences, University Teknologi MARA (UiTM) Sarawak Jalan Meranek) ;
  • Zulkifli, Razauden Mohamed (Department of Bioscience and Health Sciences, Faculty of Biosciences and Medical Engineering, University Teknologi Malaysia (UTM))
  • Received : 2016.01.22
  • Accepted : 2016.03.07
  • Published : 2016.12.31
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Abstract

Phytochemical investigation from the stem bark of Beilschmiedia pulverulenta resulted in the isolation of five lignans, (+)-yangambin (1), (+)-sesartemin (2), (+)-excelsin (3), (+)-sesamin (4), and (+)-syringaresinol (5), together with lupeol (6), lupenone (7), ${\beta}-sitosterol$ (8), and ${\beta}-sitostenone$ (9). Their structures were established by the analysis of their spectroscopic (1D and 2D NMR) and spectrometric (MS) data, as well as by comparison with those reported in the literature. The isolated lignans were tested for their anticholinesterase (AChE: acetylcholine esterase and BChE: butyryl cholineesterase) and anti-inflammatory (COX-2: cyclooxygenase-2 and LOX: lipoxygenase) activities. All the isolated lignans (1 - 5) exhibited significant inhibition activities in AChE/BChE and COX-2/LOX assays with $IC_{50}$ values ranging from $168.8-504.2{\mu}M$ and $21.0-59.4{\mu}M$, respectively.

Keywords

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