DOI QR코드

DOI QR Code

야채추출물의 융복합적 암세포 증식 억제효과

Antiproliferative Activity of Convergence of Vegetable Extract in Cancer cells

  • 투고 : 2015.11.27
  • 심사 : 2016.01.20
  • 발행 : 2016.01.28

초록

본 논문은 야채추출물의 인간 암세포 증식 억제효과를 살펴보는 데 목적이 있다. 본 연구는 일반적으로 야채수프에 사용되는 무, 무청, 우엉, 표고버섯, 당근등의 야채추출물을 이용하여 암세포 증식 억제효과를 살펴보았다. 인간 암세포주는 위암 (AGS) 세포주, 급성 전골수성 백혈병 (HL-60) 세포주, 폐암 (A549) 세포주를 사용하였으며 MTS방법으로 암세포 증식 억제를 확인하였다. 위암 세포주는 표고버섯과 당근에서 암세포 증식 억제효과가 있었으며 급성 전골수성 백혈병 세포주는 무청, 우엉, 당근에서 암세포 증식 억제효과가 있었으며 특히 우엉과 당근에서 유의성 있는 억제를 보였으며 폐암 세포주는 무, 무청에서 탁월한 효과를 보였다. 암세포 증식억제 효과가 있는 야채추출물을 이용한 야채스프는 항암성이 있는 기능성 소재로 활용과 융복합적인 웰리스를 위한 기초 자료로 활용이 가능하다고 사료된다.

The present sturdy was designed to determine the effect of the antiproliferation in human cancer cells, using vegetable extract of Radish, Radish leaves, Burdock, Shiitake, Carrot of the ordinary vegetable soup. Human cancer cells identify the cancer cell growth with MTS, using stomach cancer cell line (AGS), human promyelocytic leukemia (HL-60) and lung cancer cell line (A549). Shiitake and Carrot are effective on the cancer cell growth inhibition activities of AGS. Radish leaves, Burdock, Carrot have a significance with HL-60 and Radish, Radish leaves works well in A549. The vegetable extracts which is effective for cancer cell growth inhibition is considered to applicate base line data for using functional materials and for wellness life.

키워드

참고문헌

  1. I.. Goleberg, Functional Foods. Chapman & Hall Press, New York, NY, USA. pp. 350-550, 1994.
  2. J. G. Sim, J. H. Lee, T. Y. Shin, H. Y. Shin, S. H. Jeong, M. H. Kim, H. J. Ku, J. S. Park, Anti-Inflammatory Effects of Vegetable Soup in Murine Macrophage RAW 264.7 Cells.J Korean Soc Food Sci Nutr.,Vol. .39, pp.1097 - 1101, 2010 https://doi.org/10.3746/jkfn.2010.39.8.1097
  3. O. Sadaki, The development of functional foods and material. Bio-industry, Vol. 13, pp.44-50, 1996.
  4. M. I. Heinonen, Carotenoids and provitamin A activity of carrot (Daucus carrota L.) cultivars. J Agric Food Chem.., Vol.38, pp. ,609-612, 1990. https://doi.org/10.1021/jf00093a005
  5. P. W. Simon, Carrots and other horticultural crops as a source of provitamin A carotenes. Hortscience, Vol. 25, No. 12, pp.1495-1499, 1990.
  6. H. H. Weisburger, Nutritional approach to cancer prevention with emphasis on vitamins, antioxidants and carotenoids. Amer J Clin Nutr., Vol. 53, pp.2265-2375, 1991.
  7. A. Bendich, Recent advances in clinical research involving carotenoids. Pure Appl Chem.., Vol. 66, pp.1017-1025, 1994. https://doi.org/10.1351/pac199466051017
  8. H. B. Yim, G. Lee, H. J. Chae, Cytotoxicity of ethanol extract of Raphanuse sativus on human lung cacer cell lines. J Korean Soc Food Sci Nutr., Vol. 33, pp. 287-290, 2004. https://doi.org/10.3746/jkfn.2004.33.2.287
  9. A. Shimotoyodome, S. Meguro, T. Hase, I. Sakata, Sulfated polysaccharides, but not cellulose, increase colonic mucus in rats with loperamide-induced constipation. Digest Dis Sci., Vol. 46, pp.1482-1489, 2001. https://doi.org/10.1023/A:1010644021888
  10. H. Matsuoka, Y. Toda, K. Yoneyama, Y. Uda, Formation of raphanusanius depends on extraction procedure and solvent. Phytochemistry, Vol. 47, pp.957-977, 1998.
  11. K. Monde, M. Takasugi, A. Shirata, Three sulphur-containing stress metabolites from Japanese radish. Phytochemistry, Vol. 39, pp. 581-586, 1995. https://doi.org/10.1016/0031-9422(95)00011-U
  12. K. H. Ku, K. A. Lee, Y. L. Kim, Y. W. Lee, Quality characteristics of hot-air dried radish (Raphanus sativus L.) leaves. J Korean Soc Food Sci Nutr., Vol.34, pp.780-785, 2006.
  13. M. N. Ghayur, A. H. Gilani, Gastrointestinal stimulatory and uterotonic activities of dietary radish leaves extract are mediated through multiple pathways. Phytother Res., Vol.19, pp.750-755, 2005. https://doi.org/10.1002/ptr.1753
  14. H. Takeda, S. Kiriyama, Difference between rats and chicks in the protective effect of dietary fiber against amaranth toxicity. Agri Bio Chem., Vol. 55, No. 5, pp.1299, 1991. https://doi.org/10.1271/bbb1961.55.1299
  15. H. Takeda, S. Kiriyama, Effect of feeding amaranth on the jejunal sucrase and digestion-absorption capacity of the jejunum in rats. J Nutr sci and Vit., Vol. 37, No. 6, pp.611, 1991. https://doi.org/10.3177/jnsv.37.611
  16. M. H. Park, K. Y. Oh, B. W. Lee, Anti-cancer of Lentinus edodes and Pleurotus astreatus. Korean J Food Sci Technol., Vol. 30, pp.702-708, 1998.
  17. A. Desai, T. Vyas, M. Amiji, Cyroroxicity and apoptosis enhancement in brain tumor cells upon coadministration of paclitaxel and ceramide in nanoemulsion formulations. J Pharm Sci., Vol. 9, pp.2745-2756, 2008.
  18. M.J.Bae, Y.J.Ye, Effect of Mycelia Extracts from Lentinus edodes Mushroom-Cultured Lonicera japonica Thunberg on Anticancer and Antiallergy Activities.J Korean Soc Food Sci Nutr.,Vol..36 no.4, pp.424 - 430, 2007. https://doi.org/10.3746/jkfn.2007.36.4.424
  19. D. Stephen, Carotenoid-rich vegetables linked to less stomach cancer.Cancer Epidemiology Biomarkers & Prevention, Vol. 15 1998-2001, 2006.
  20. M. S. Jeong, K. S. Lee, In vitro Biological Activity Assay of Ethanol Extract of Radish. Journal of the Korean Society for Applied Biological Chemistry, Vol. 47, pp.67 - 71, 2004,
  21. K. H. Ku, K.A. Lee, Y. Y. Kim, Physiological Activity of Extracts from Radish (Raphanus sativus L.) Leaves. J Korean Soc Food Sci Nutr.,Vol .37, pp.390 - 395, 2008. https://doi.org/10.3746/jkfn.2008.37.3.390