참고문헌
- Aramburu, J., Garcia-Cozar, F., Raghavan, A., Okamura, H., Rao, A., and Hogan, P.G. (1998). Selective inhibition of NFAT activation by a peptide spanning the calcineurin targeting site of NFAT. Mol. Cell 1, 627-637. https://doi.org/10.1016/S1097-2765(00)80063-5
- Bandyopadhyay, J., Lee, J., Lee, J., Lee, J.I., Yu, J.R., Jee, C., Cho, J.H., Jung, S., Lee, M.H., Zannoni, S., et al. (2002). Calcineurin, a calcium/calmodulin-dependent protein phosphatase, is involved in movement, fertility, egg laying, and growth in Caenorhabditis elegans. Mol. Biol. Cell 13, 3281-3293. https://doi.org/10.1091/mbc.E02-01-0005
- Chang, K.T., and Min, K.T. (2009). Upregulation of three Drosophila homologs of human chromosome 21 genes alters synaptic function: implications for Down syndrome. Proc. Natl. Acad. Sci. USA 106, 17117-17122. https://doi.org/10.1073/pnas.0904397106
- Chang, K.T., Shi, Y.J., and Min, K.T. (2003). The Drosophila homolog of Down's syndrome critical region 1 gene regulates learning: implications for mental retardation. Proc. Natl. Acad. Sci. USA 100, 15794-15799. https://doi.org/10.1073/pnas.2536696100
- Crawford, D.R., Leahy, K.P., Abramova, N., Lan, L., Wang, Y., and Davies, K.J. (1997). Hamster adapt78 mRNA is a Down syndrome critical region homologue that is inducible by oxidative stress. Arch. Biochem. Biophys. 342, 6-12. https://doi.org/10.1006/abbi.1997.0109
- Dierssen, M., Arque, G., McDonald, J., Andreu, N., Martinez-Cue, C., Florez, J., and Fillat, C. (2011). Behavioral characterization of a mouse model overexpressing DSCR1/ RCAN1. PLoS One 6, e17010. https://doi.org/10.1371/journal.pone.0017010
- Ermak, G., Morgan, T.E., and Davies, K.J. (2001). Chronic overexpression of the calcineurin inhibitory gene DSCR1 (Adapt78) is associated with Alzheimer's disease. J. Biol. Chem. 276, 38787-38794. https://doi.org/10.1074/jbc.M102829200
- Fuentes, J.J., Pritchard, M.A., Planas, A.M., Bosch, A., Ferrer, I., and Estivill, X. (1995). A new human gene from the Down syndrome critical region encodes a proline-rich protein highly expressed in fetal brain and heart. Hum. Mol. Genet. 4, 1935-1944. https://doi.org/10.1093/hmg/4.10.1935
- Fuentes, J.J., Pritchard, M.A., and Estivill, X. (1997). Genomic organization, alternative splicing, and expression patterns of the DSCR1 (Down syndrome candidate region 1) gene. Genomics 44, 358-361. https://doi.org/10.1006/geno.1997.4866
- Fuentes, J.J., Genesca, L., Kingsbury, T.J., Cunningham, K.W., Perez-Riba, M., Estivill, X., and de la Luna, S. (2000). DSCR1, overexpressed in Down syndrome, is an inhibitor of calcineurinmediated signaling pathways. Hum. Mol. Genet. 9, 1681-1690. https://doi.org/10.1093/hmg/9.11.1681
- Genesca, L., Aubareda, A., Fuentes, J.J., Estivill, X., De La Luna, S., and Perez-Riba, M. (2003). Phosphorylation of calcipressin 1 increases its ability to inhibit calcineurin and decreases calcipressin half-life. Biochem. J. 374, 567-575. https://doi.org/10.1042/bj20030267
- Gorlach, J., Fox, D.S., Cutler, N.S., Cox, G.M., Perfect, J.R., and Heitman, J. (2000). Identification and characterization of a highly conserved calcineurin binding protein, CBP1/calcipressin, in Cryptococcus neoformans. EMBO J. 19, 3618-3629. https://doi.org/10.1093/emboj/19.14.3618
- Hilioti, Z., Gallagher, D.A., Low-Nam, S.T., Ramaswamy, P., Gajer, P., Kingsbury, T.J., Birchwood, C.J., Levchenko, A., and Cunningham, K.W. (2004). GSK-3 kinases enhance calcineurin signaling by phosphorylation of RCNs. Genes Dev. 18, 35-47. https://doi.org/10.1101/gad.1159204
- Hoeffer, C.A., Dey, A., Sachan, N., Wong, H., Patterson, R.J., Shelton, J.M., Richardson, J.A., Klann, E., and Rothermel, B.A. (2007). The Down syndrome critical region protein RCAN1 regulates long-term potentiation and memory via inhibition of phosphatase signaling. J. Neurosci. 27, 13161-13172. https://doi.org/10.1523/JNEUROSCI.3974-07.2007
- Keating, D.J., Dubach, D., Zanin, M.P., Yu, Y., Martin, K., Zhao, Y.F., Chen, C., Porta, S., Arbones, M.L., Mittaz, L., et al. (2008). DSCR1/RCAN1 regulates vesicle exocytosis and fusion pore kinetics: implications for Down syndrome and Alzheimer's disease. Hum. Mol. Genet. 17, 1020-1030. https://doi.org/10.1093/hmg/ddm374
- Kingsbury, T.J., and Cunningham, K.W. (2000). A conserved family of calcineurin regulators. Genes Dev. 14, 1595-1604.
- Kishi, T., Ikeda, A., Nagao, R., and Koyama, N. (2007). The SCFCdc4 ubiquitin ligase regulates calcineurin signaling through degradation of phosphorylated Rcn1, an inhibitor of calcineurin. Proc. Natl. Acad. Sci. USA 104, 17418-17423. https://doi.org/10.1073/pnas.0704951104
- Kuhara, A., Inada, H., Katsura, I., and Mori, I. (2002). Negative regulation and gain control of sensory neurons by the C. elegans calcineurin TAX-6. Neuron 33, 751-763. https://doi.org/10.1016/S0896-6273(02)00607-4
- Kurabayashi, N., and Sanada, K. (2013). Increased dosage of DYRK1A and DSCR1 delays neuronal differentiation in neocortical progenitor cells. Genes Dev. 27, 2708-2721. https://doi.org/10.1101/gad.226381.113
- Lee, J.I., Dhakal, B.K., Lee, J., Bandyopadhyay, J., Jeong, S.Y., Eom, S.H., Kim, D.H., and Ahnn, J. (2003). The Caenorhabditis elegans homologue of down syndrome critical region 1, RCN-1, inhibits multiple functions of the phosphatase calcineurin. J. Mol. Biol. 328, 147-156. https://doi.org/10.1016/S0022-2836(03)00237-7
- Li, W., Bell, H.W., Ahnn, J., and Lee, S.K. (2015). Regulator of Calcineurin (RCAN-1) Regulates Thermotaxis Behavior in Caenorhabditis elegans. J. Mol. Biol. 427, 3457-3468. https://doi.org/10.1016/j.jmb.2015.07.017
- Martin, K.R., Corlett, A., Dubach, D., Mustafa, T., Coleman, H.A., Parkington, H.C., Merson, T.D., Bourne, J.A., Porta, S., Arbones, M.L., et al. (2012). Over-expression of RCAN1 causes Down syndrome-like hippocampal deficits that alter learning and memory. Hum. Mol. Genet. 21, 3025-3041. https://doi.org/10.1093/hmg/dds134
- Mehta, S., Li, H., Hogan, P.G., and Cunningham, K.W. (2009). Domain architecture of the regulators of calcineurin (RCANs). and identification of a divergent RCAN in yeast. Mol. Cell. Biol. 29, 2777-2793. https://doi.org/10.1128/MCB.01197-08
- Park, B.J., Lee, J., II, Lee, J., Kim, S., Choi, K.Y., Park, C.S., and Ahnn, J. (2001a). Isolation of deletion mutants by reverse genetics incaenorhabditis elegans. Korean J. Biol. Sci. 5, 65-69. https://doi.org/10.1080/12265071.2001.9647584
- Park, B.J., Lee, D.G., Yu, J.R., Jung, S.K., Choi, K., Lee, J., Lee, J., Kim, Y.S., Lee, J.I., Kwon, J.Y., et al. (2001b). Calreticulin, a calcium-binding molecular chaperone, is required for stress response and fertility in Caenorhabditis elegans. Mol. Biol. Cell 12, 2835-2845. https://doi.org/10.1091/mbc.12.9.2835
- Reynolds, L.E., Watson, A.R., Baker, M., Jones, T.A., D'Amico, G., Robinson, S.D., Joffre, C., Garrido-Urbani, S., Rodriguez-Manzaneque, J.C., Martino-Echarri, E., et al. (2010). Tumour angiogenesis is reduced in the Tc1 mouse model of Down's syndrome. Nature 465, 813-817. https://doi.org/10.1038/nature09106
- Trent, C., Tsuing, N., and Horvitz, H.R. (1983). Egg-laying defective mutants of the nematode Caenorhabditis elegans. Genetics 104, 619-647.
- Wang, W., Zhu, J.Z., Chang, K.T., and Min, K.T. (2012). DSCR1 interacts with FMRP and is required for spine morphogenesis and local protein synthesis. EMBO J. 31, 3655-3666. https://doi.org/10.1038/emboj.2012.190
- Wang, W., Rai, A., Hur, E.M., Smilansky, Z., Chang, K.T., and Min, K.T. (2016). DSCR1 is required for both axonal growth cone extension and steering. J. Cell Biol. 213, 451-462. https://doi.org/10.1083/jcb.201510107
- Wiese, A.G., Pacifici, R.E., and Davies, K.J. (1995). Transient adaptation of oxidative stress in mammalian cells. Arch. Biochem. Biophys. 318, 231-240. https://doi.org/10.1006/abbi.1995.1225
- Yang, J., Rothermel, B., Vega, R.B., Frey, N., McKinsey, T.A., Olson, E.N., Bassel-Duby, R., and Williams, R.S. (2000). Independent signals control expression of the calcineurin inhibitory proteins MCIP1 and MCIP2 in striated muscles. Circ. Res. 87, E61-68. https://doi.org/10.1161/01.RES.87.12.e61
피인용 문헌
- RCAN1 in the inverse association between Alzheimer’s disease and cancer vol.9, pp.1, 2016, https://doi.org/10.18632/oncotarget.23094
- A spontaneous complex structural variant in rcan-1 increases exploratory behavior and laboratory fitness of Caenorhabditis elegans vol.16, pp.2, 2016, https://doi.org/10.1371/journal.pgen.1008606
- Caenorhabditis elegans phosphatase complexes in UniProtKB and Complex Portal vol.287, pp.13, 2016, https://doi.org/10.1111/febs.15213