대한의용생체공학회:의공학회지 (Journal of Biomedical Engineering Research)

  • 제37권5호
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  • Pages.178-185
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  • 2016
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  • 1229-0807(pISSN)
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  • 2288-9396(eISSN)
대한의용생체공학회 (The Korean Society of Medical and Biological Engineering)
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눈물의 생체 분자 추출을 위한 미세유관이 탑재된 유연한 콘택트 렌즈

Micro-channel Embedded Soft Contact Lens for Tear Biomolecule Sampling

  • 김옥철 (과학기술연합대학원대학교) ;
  • 박형달 (연세대학교 기계공학과) ;
  • 송용원 (한국과학기술연구원 차세대반도체연구소 광전소재연구단) ;
  • 김진석 (한국과학기술연구원 의공학연구소 바이오닉스연구단)
  • Kim, Ockchul (University of Science and Technology) ;
  • Park, HyungDal (Department of Mechanical Engineering, Yonsei University) ;
  • Song, Young-won (Center for Opto-Electronic Materials and Devices, Post-Silicon Semiconductor Institute, Korea Institute of Science and Technology) ;
  • Kim, Jinseok (Center for Bionics, Biomedical Research Institute, Korea Institute of Science and Technology)
  • 투고 : 2016.09.27
  • 심사 : 2016.11.15
  • 발행 : 2016.10.31
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초록

Tear is a promising biological fluid for non-invasive health monitoring. It has been studied in the past to be a possible candidate for the diagnosis of certain systemic diseases, such as breast cancer, multiple sclerosis, prostate cancer, and diabetes. However, currently existing methods for collecting and extracting tear from the human eye causes inconsistencies in the biomolecule concentrations of the tear sample due to the irritating nature of the process. In response, we designed and fabricated a microfluidic system embedded soft contact-lens for the purpose of tear sampling. The lens was then tested with artificial tear for its tear sampling capability, and found to be able to find concentration equilibrium within 50 minutes. Additionally, simulation was carried out to further optimize the design so that tear sampling rate matched the natural tear turn-over rate of 1 microliter per minute.

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참고문헌

  1. A. Lebrecht, D. Boeham, M. Schmidt, H. Koelbl, and H. Gruz, "Surface-enhanced Laser Desorption/Ionisation Time-of-flight Mass Spectrometry to Detect Breast Cancer Markers in Tears and serum," Cancer Genomics and Proteomics, vol. 6, no. 2, pp. 75-83, 2008.
  2. C. Salvisberg, N. Tajouri, A. Hainard, P.R. Burkhard, P.H. Lalive, and N. Turck, "Exploring the human tear fluid: Discovery of new biomarkers in multiple sclerosis," PROTEOMICS - Clinical Applications Prot. Clin. Appl., vol. 8, no. 3-4, pp. 185-194, 2014. https://doi.org/10.1002/prca.201300053
  3. D. Pieragostino, M. D'alessandro, M.D. Ioia, C.D. Ilio, P. Sacchetta, and P.D. Boccio, "Unraveling the molecular repertoire of tears as a source of biomarkers: Beyond ocular diseases," PROTEOMICS - Clinical Applications Prot. Clin. Appl., vol. 9, no. 1-2, pp. 169-186, Dec. 2015. https://doi.org/10.1002/prca.201400084
  4. J.T. Baca, D.N. Finegold, and S.A. Asher, "Tear Glucose Analysis for the Noninvasive Detection and Monitoring of Diabetes Mellitus," The Ocular Surface, vol. 5, no. 4, pp. 280-293, 2007. https://doi.org/10.1016/S1542-0124(12)70094-0
  5. J. Zhang, W. Hodge, C. Hutnick, X. Wang, "Noninvasive Diagnostic Devices for Diabetes through Measuring Tear Glucose," J Diabetes Sci Technol, vol. 5, no. 1, pp. 166-172, 2011. https://doi.org/10.1177/193229681100500123
  6. J.D. Lane, D.M. Krumholz, R.A. Sack, C. Morris, "Tear Glucose Dynamics in Diabetes Mellitus," Curr Eye Res, vol. 31, no. 11, pp. 895-901, 2006. https://doi.org/10.1080/02713680600976552
  7. Verpoorte E, "Microfluidic chips for clinical and forensic analysis," Electrophoresis, vol. 23, No. 5, pp. 677-712, 2002. https://doi.org/10.1002/1522-2683(200203)23:5<677::AID-ELPS677>3.0.CO;2-8
  8. K.N. Han, C.A. Li, G.H. Seong, "Microfluidic Chips for Immunoassays," Annu Rev Anal Chem, vol. 6, pp. 119-141, 2013. https://doi.org/10.1146/annurev-anchem-062012-092616
  9. X. Feng, B. Liu, J. Li, X. Liu, "Advances in Coupling Microfluidic Chips to Mass Spectrometry", Mass Spectrom Rev, vol. 34, no. 5, pp. 535-557, 2015. https://doi.org/10.1002/mas.21417
  10. R.K. Hobbie, B.J. Roth, Intermediate Physics for Medicine and Biology, New York, USA: Springer-Verlag, 2007.