정보과학회 논문지 (Journal of KIISE)

  • 제43권1호
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  • Pages.54-60
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  • 2016
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  • 2383-630X(pISSN)
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  • 2383-6296(eISSN)
한국정보과학회 (Korean Institute of Information Scientists and Engineers)
권호 표지
DOI QR코드

DOI QR Code

쥐 해마의 유전자 발현 그리드 데이터를 이용한 특징기반 유전자 분류 및 영역 군집화

Feature-based Gene Classification and Region Clustering using Gene Expression Grid Data in Mouse Hippocampal Region

  • 강미선 (이화여자대학교 컴퓨터공학과) ;
  • 김혜련 (이화여자대학교 컴퓨터공학과) ;
  • 이석찬 (한국과학기술연구원) ;
  • 김명희 (이화여자대학교 컴퓨터공학과)
  • 투고 : 2015.06.29
  • 심사 : 2015.11.11
  • 발행 : 2016.01.15
⟨ 이전 논문 다음 논문 ⟩

초록

뇌의 유전자 발현 정보는 영역별 기능과 밀접한 관련이 있어 이를 분석하기 위해 다수의 유전자들 간의 발현 정도 및 발현 위치 정보와의 관계에 대한 연구가 이루어지고 있다. 본 논문에서는 컴퓨터 기술을 통해 알렌 뇌과학연구소에서 제공하는 약 2만여개의 쥐 뇌 유전자 발현 정보 중 뇌의 해마 영역을 중점적으로 분석하여 유전자들을 자동으로 분류해내고 발현 위치 정보를 기반으로 군집화하여 가시화하는 방법을 제안한다. 이를 통해 해마 내 전체적으로 발현되는 유전자들과 특정 영역에만 발현되는 유전자들을 분류할 수 있었고 그 중 특정 영역에 발현되는 유전자들의 위치정보 기반으로 군집화된 데이터를 뇌 지도와 함께 관찰 할 수 있었다. 본 연구는 뇌의 기능과 영역과의 관계성 관련 생물학적 연구를 위한 실험군 선정작업에 이용되어 실험설계시간을 줄일 수 있고 기존에 알려진 뇌의 해부학적 구조보다 더욱 세분화된 구조를 발견할 수 있는 가능성을 제시할 것으로 기대된다.

Brain gene expression information is closely related to the structural and functional characteristics of the brain. Thus, extensive research has been carried out on the relationship between gene expression patterns and the brain's structural organization. In this study, Principal Component Analysis was used to extract features of gene expression patterns, and genes were automatically classified by spatial distribution. Voxels were then clustered with classified specific region expressed genes. Finally, we visualized the clustering results for mouse hippocampal region gene expression with the Allen Brain Atlas. This experiment allowed us to classify the region-specific gene expression of the mouse hippocampal region and provided visualization of clustering results and a brain atlas in an integrated manner. This study has the potential to allow neuroscientists to search for experimental groups of genes more quickly and design an effective test according to the new form of data. It is also expected that it will enable the discovery of a more specific sub-region beyond the current known anatomical regions of the brain.

키워드

과제정보

연구 과제 주관 기관 : 미래창조과학부, 정보통신기술진흥센터, 한국연구재단

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