DOI QR코드

DOI QR Code

Do-not-resuscitation in Terminal Cancer Patient

말기암환자에서 심폐소생술금지

  • Kwon, Jung Hye (Division of Hematology-Oncology, Department of Internal Medicine, Hallym University College of Medicine)
  • 권정혜 (한림대학교 강동성심병원 혈액종양내과)
  • Received : 2015.08.12
  • Accepted : 2015.08.18
  • Published : 2015.09.01

Abstract

For patients who are near the end of life, an inevitable step is discussion of a do-not-resuscitate (DNR) order, which involves patients, their family members and physicians. To discuss DNR orders, patients and family members should know the meaning of the order and cardiopulmonary resuscitation (CPR) which includes chest compression, defibrillation, medication to restart the heart, artificial ventilation, and tube insertion in the respiratory tract. And the following issues should be considered as well: patients' and their families' autonomy, futility of treatment, and the right for death with dignity. Terminal cancer patients should be informed of what futility of treatment is, such as a low survival rate of CPR, unacceptable quality of life after CPR, and an irremediable disease status. In Korea, two different law suits related to life supporting treatments had been filed, which in turn raised public interest in death with dignity. Since the 1980s, knowledge of and attitude toward DNR among physicians and the public have been improved. However, most patients are still alienated from the decision making process, and the decision is often made less than a week before death. Thus, the DNR discussion process should be improved. Early palliative care should be adopted more widely.

환자가 죽음에 임박했을 때 환자, 보호자, 의사 사이에서 심폐소생술에 대한 논의는 피할 수 없는 주제이다. 환자가 회복 불가능한 말기의 암환자인 경우에는 환자의 품위 있는 죽음을 고려하여 심폐소생술을 시행하지 않음(Do-not-resuscitate, DNR)을 결정하게 된다. 그러나 DNR에 대한 선택은 환자와 보호자의 심폐소생술과 DNR의 의미 및 그 결과에 대한 이해를 바탕으로 한다. DNR에 대하여 환자, 보호자, 의료진이 상담을 할 때는 환자의 질환이 더 이상 치료가 불가능하며, 심폐소생술이 환자의 생명을 연장시키는 것이 아니라 죽음의 과정을 연장시키는 것이며, 심폐소생술 이후에 삶의 질이 급격히 나빠질 수 있는 상황이라는 합의가 필요하다. 충분한 이해는 환자 또는 보호자가 품위 있는 죽음을 위한 DNR을 선택하도록 한다. 국내에서는 DNR 자체 보다는 이미 생명유지장치를 가지고 있는 환자에서의 생명유지장치의 제거에 대한 법적인 문제가 2차례 발생하면서 사회적으로 품위 있는 죽음에 대한 일반 대중의 관심이 이전보다 증가하였다. 환자와 의료진을 대상으로 한 설문에서는 DNR에 대한 인식과 의지가 80년대에 비해 2000년대 초반에 이르러 상당히 증가하였으나, 실제 의료 현장에서는 DNR의 결정에 있어 환자가 직접 관여를 하는 경우는 많지 않았고 DNR 작성 시점과 사망 시점과의 시간 간격이 1주 이내로 환자가 관여를 하거나 임종시기의 의료를 결정하기에는 너무 짧은 문제가 있었다. 이러한 문제는 조기 완화의료의 확산을 통하여 개선이 가능할 것으로 생각된다. 일부에서는 DNR이라는 용어보다는 자연적인 죽음을 허용함(Allow-Natural-Death)이라는 용어로 바꾸어서 설명하는 것이 이해를 돕고 선택의 갈등을 줄인다는 보고를 하여 DNR 논의와 결정에 있어서 적절한 시기 이외에도 환자와 보호자에게 많은 어려움이 있다는 것을 보여 주고 있다. DNR은 말기암환자에서 품위 있는 죽음을 위해 고려해야 하는 사항이며, 임상에서 DNR이 잘 시행되도록 임상적, 제도적 노력이 필요하다.

Keywords

References

  1. Park HS, Koo MJ, Kim YH. Concept analysis of DNR (Donot-Resuscitate). J Korean Acad Nurs 2006;36:1055-64. https://doi.org/10.4040/jkan.2006.36.6.1055
  2. Simpson SH. A study into the uses and effects of do-notresuscitate orders in the intensive care units of two teaching hospitals. Intensive Crit Care Nurs 1994;10:12-22. https://doi.org/10.1016/0964-3397(94)90074-4
  3. Jonsen AR, Veatch RM, Walters L. Source book in bioethics. Washington, D.C.:Georgetown University Press;1999.
  4. Kouwenhoven WB, Jude JR, Knickerbocker GG. Closed-chest cardiac massage. JAMA 1960;173:1064-7. https://doi.org/10.1001/jama.1960.03020280004002
  5. Jude JR, Kouwenhoven WB, Knickerbocker GG. A new approach to cardiac resuscitation. Ann Surg 1961;154:311-9. https://doi.org/10.1097/00000658-196109000-00002
  6. Fried C. Editorial: Terminating life support: out of the closet. N Engl J Med 1976:295:390-1. https://doi.org/10.1056/NEJM197608122950711
  7. Bedell SE, Delbanco TL, Cook EF, Epstein FH. Survival after cardiopulmonary resuscitation in the hospital. N Engl J Med 1983;309:569-76. https://doi.org/10.1056/NEJM198309083091001
  8. Saklayen M, Liss H, Markert R. In-hospital cardiopulmonary resuscitation. Survival in 1 hospital and literature review. Medicine (Baltimore) 1995;74:163-75. https://doi.org/10.1097/00005792-199507000-00001
  9. Reisfield GM, Wallace SK, Munsell MF, Webb FJ, Alvarez ER, Wilson GR. Survival in cancer patients undergoing in-hospital cardiopulmonary resuscitation: a meta-analysis. Resuscitation 2006; 71:152-60. https://doi.org/10.1016/j.resuscitation.2006.02.022
  10. Optimum care for hopelessly ill patients. A report of the Clinical Care Committee of the Massachusetts General Hospital. N Engl J Med 1976;295:362-4. https://doi.org/10.1056/NEJM197608122950704
  11. United States. President's Commission for the Study of Ethical Problems in Medicine and Biomedical and Behavioral Research, Concern for Dying (Association). Deciding to forego lifesustaining treatment : a report on the ethical, medical, and legal issues in treatment decisions. Washington, DC:President's Commission for the Study of Ethical Problems in Medicine and Biomedical and Behavioral Research;1983.
  12. Koh Y, Heo DS, Yun YH, Moon JL, Park HW, Choung JT, et al. Characteristics and issues of guideline to withdrawal of a lifesustaining therapy. J Korean Med Assoc 2011;54:747-57. https://doi.org/10.5124/jkma.2011.54.7.747
  13. Korean Initiative for Advance Directive. Advance directive [Internet]. Seoul: Korean Initiative for Advance Directive; c2014 [cited 2015 Aug 2]. Available from: http://www.sasilmo.net/bbs/board.php?bo_table=download&wr_id=1&page=0.
  14. Cho DY. Attitudes of Korean physicians toward telling truth to the dying patient. J Korean Neuropsychiar Assoc 1981;20:1-16.
  15. Han SW, Han SH, Cung HY. A study on the attitudes toward dying patients. J Korean Neuropsychiar Assoc 1990;29:1408-28.
  16. Lee SR, Shin DS, Choi YJ. Perceptions of caregivers and medical staff toward DNR and AD. Korean J Hosp Palliat Care 2014; 17:66-74. https://doi.org/10.14475/kjhpc.2014.17.2.66
  17. Yun YH, Han KH, Park S, Park BW, Cho CH, Kim S, et al. Attitudes of cancer patients, family caregivers, oncologists and members of the general public toward critical interventions at the end of life of terminally ill patients. CMAJ 2011;183:E673-9. https://doi.org/10.1503/cmaj.110020
  18. Kang KJ, Ju SJ. Ethical attitudes, perceptions of DNR and advance directives of general population. J Korean Acad Psychiatr Ment Health Nurs 2014;23:113-23. https://doi.org/10.12934/jkpmhn.2014.23.2.113
  19. Kwon JH, Lim YO, Kim do Y, Shin JJ. Analysis of agreement to do-not-resuscitate in a Korean university hospital. 2015 Summer Symposium of Korean Society for Hospice and Palliative Care; 2015 Jul 7; Jeonju, Korea. Seoul: Korean Society for Hospice and Palliative Care; 2015. Abstract p. 25.
  20. Robinson C, Kolesar S, Boyko M, Berkowitz J, Calam B, Collins M. Awareness of do-not-resuscitate orders: what do patients know and want? Can Fam Physician 2012;58:e229-33.
  21. Yun YH, Lee MK, Kim SY, Lee WJ, Jung KH, Do YR, et al. Impact of awareness of terminal illness and use of palliative care or intensive care unit on the survival of terminally ill patients with cancer: prospective cohort study. J Clin Oncol 2011;29: 2474-80. https://doi.org/10.1200/JCO.2010.30.1184
  22. Hospice and Palliative Care. Current status of palliative care professional organizations [Internet]. Goyang: Hospice and Palliative Care; c2014 [cited 2015 Aug 2]. Available from: http://hospice.cancer.go.kr/home/contentsInfo.do?menu_no=443&brd_mgrno.
  23. Oh DY, Kim JE, Lee CH, Lim JS, Jung KH, Heo DS, et al. Discrepancies among patients, family members, and physicians in Korea in terms of values regarding the withholding of treatment from patients with terminal malignancies. Cancer 2004;100: 1961-6. https://doi.org/10.1002/cncr.20184
  24. Kim do Y, Lee KE, Nam EM, Lee HR, Lee KW, Kim JH, et al. Do-not-resuscitate orders for terminal patients with cancer in teaching hospitals of Korea. J Palliat Med 2007;10:1153-8. https://doi.org/10.1089/jpm.2006.0264
  25. Oh DY, Kim JH, Kim DW, Im SA, Kim TY, Heo DS, et al. CPR or DNR? End-of-life decision in Korean cancer patients: a single center's experience. Support Care Cancer 2006;14:103-8. https://doi.org/10.1007/s00520-005-0885-5
  26. Song T, Kim K, Koh Y. Factors determining the establishment of DNR orders in oncologic patients at a university hospital in Korea. Korean J Med 2008;74:403-10.
  27. Lee K, Jang HJ, Hong SB, Lim CM, Koh Y. Do-not-resuscitate order in patients, who were deceased in a medical intensive care unit of an university hospital in Korea. Korean J Crit Care Med 2008;23:84-9. https://doi.org/10.4266/kjccm.2008.23.2.84
  28. Kwon YC, Shin DW, Lee JH, Heo DS, Hong YS, Kim SY, et al. Impact of perception of socioeconomic burden on advocacy for patient autonomy in end-of-life decision making: a study of societal attitudes. Palliat Med 2009;23:87-94. https://doi.org/10.1177/0269216308099244
  29. Ruhnke GW, Wilson SR, Akamatsu T, Kinoue T, Takashima Y, Goldstein MK, et al. Ethical decision making and patient autonomy: a comparison of physicians and patients in Japan and the United States. Chest 2000;118:1172-82. https://doi.org/10.1378/chest.118.4.1172
  30. Morita T, Oyama Y, Cheng SY, Suh SY, Koh SJ, Kim HS, et al. Palliative care physicians' attitudes toward patient autonomy and a good death in East Asian countries. J Pain Symptom Manage 2015;50:190-9. https://doi.org/10.1016/j.jpainsymman.2015.02.020
  31. Pirl WF, Greer JA, Traeger L, Jackson V, Lennes IT, Gallagher ER, et al. Depression and survival in metastatic non-small-cell lung cancer: effects of early palliative care. J Clin Oncol 2012; 30:1310-5. https://doi.org/10.1200/JCO.2011.38.3166
  32. Temel JS, Greer JA, Muzikansky A, Gallagher ER, Admane S, Jackson VA, et al. Early palliative care for patients with metastatic non-small-cell lung cancer. N Engl J Med 2010;363:733-42. https://doi.org/10.1056/NEJMoa1000678
  33. Ahmed N, Lobchuk M, Hunter WM, Johnston P, Nugent Z, Sharma A, et al. How, when and where to discuss do not resuscitate: a prospective study to compare the perceptions and preferences of patients, caregivers, and health care providers in a multidisciplinary lung cancer clinic. Cureus 2015;7:e257.
  34. Shin J. Temel J. Integrating palliative care: when and how? Curr Opin Pulm Med 2013;19:344-9.
  35. NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines$^{(R)}$): Palliative Care [Internet]. Fort Washington: National Comprehensive Cancer Network; c2015 [cted 2015 Aug 2]. Available from: http://www.nccn.org/professionals/physician_gls/pdf/palliative.pdf.
  36. Yuen JK, Reid MC, Fetters MD. Hospital do-not-resuscitate orders: why they have failed and how to fix them. J Gen Intern Med 2011;26:791-7. https://doi.org/10.1007/s11606-011-1632-x
  37. Miljkovic MD, Emuron D, Rhodes L, Abraham J, Miller K. "Allow Natural Death" versus "Do Not Resuscitate": What do patients with advanced cancer choose? J Palliat Med 2015;18: 457-60. https://doi.org/10.1089/jpm.2014.0369
  38. Meyer C. Allow Natural Death - Alternative to DNR? [Internet]. Rockford: Hospice Patients Alliance; c2015 [cited 2015 Aug 2]. Available from: http://www.hospicepatients.org/and.html.
  39. Cohen RW. A tale of two conversations. Hastings Cent Rep 2004;34:49.
  40. Venneman SS, Narnor-Harris P, Perish M, Hamilton M. "Allow natural death" versus "do not resuscitate": three words that can change a life. J Med Ethics 2008;34:2-6. https://doi.org/10.1136/jme.2006.018317

Cited by

  1. End-of-Life Care Practice in Dying Patients with Do-Not-Resuscitate Order: A Single Center Experience vol.21, pp.2, 2018, https://doi.org/10.14475/kjhpc.2018.21.2.51
  2. 국내 일개 2차 병원의 암환자 치료 실태 vol.21, pp.3, 2018, https://doi.org/10.14475/kjhpc.2018.21.3.84
  3. Lived Experience of Primary Decision - Makers Regarding Do-Not-Resuscitate Instruction: Using Parse's Method vol.31, pp.5, 2015, https://doi.org/10.7475/kjan.2019.31.5.540
  4. Care for critically and terminally ill patients and moral distress of physicians and nurses in tertiary hospitals in South Korea: A qualitative study vol.16, pp.12, 2015, https://doi.org/10.1371/journal.pone.0260343