Journal of Mushroom (한국버섯학회지)

The Korean Society of Mushroom Science (한국버섯학회)
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The effect of the mushrooms extract on the PSA expression in prostate cancer cells

버섯류 추출물이 전립선 암 세포 내 PSA 발현에 미치는 영향

  • 김은경 (건국대학교 식품생명과학부) ;
  • 당옥교 (건국대학교 식품생명과학부) ;
  • 최희리 (건국대학교 스포츠과학부) ;
  • 최은주 (건국대학교 스포츠과학부)
  • Received : 2015.08.10
  • Accepted : 2015.10.02
  • Published : 2015.09.30
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Abstract

Mushroom have long been valued as highly nutritious and tasty foods in many societies throughout the world. It is known for biological activities including anti-inflammatory and anti-oxidative potential. However little is known about anti-cancer property. In this study, we investigated the anti-prostate cancer activity of mushrooms. For that, eight kinds of mushrooms such as, T. matsutake, S. crispa, G. lucidum-US, G. lucidum-AS, C. cardinalis-BR, G. frondosa, P. linteus, U. esculenta were extracted with hot water. Among them, three kinds of mushrooms including T. matsutake, G. lucidum-US and C. militaris-BR extracts inhibited prostate specific antigen (PSA) expression in prostate cancer cell, LNCaP. These results demonstrate that some of mushrooms inhibited PSA expression suggesting that the mushrooms might be a candidate for the treatment of prostate cancer.

버섯은 영양소 및 풍미가 뛰어나 오래전부터 식재료로 널리 활용되고 있으며 항염증 및 항산화효능도 뛰어난 것으로 알려져 있다. 그러나 버섯의 항산화 효능은 아직 연구가 미비한 실정이다. 따라서 본 연구에서는 버섯의 항전립선암 효능을 분석하였다. 이를 위해, 식용버섯인 참송이버섯, 꽃송이버섯, 편각영지버섯, 녹각영지, 현미동충하초버섯, 잎새버섯, 석이버섯, 상황버섯 등 8종 버섯의 열수 추출물에 대한 항전립선암 효능을 전립선암 세포주인 LNCaP에서 확인한 결과 참송이버섯, 편각영지버섯 및 현미동충하초버섯이 PSA 발현을 저해하는 효능이 탁월한 것을 확인하였다.

Keywords

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