The Korean Journal of Medicine

The Korean Association of Internal Medicine (대한내과학회)
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Treatment of a Patient with Kaposi’s Sarcoma Arising during Hemodialysis with the Multikinase Inhibitor Pazopanib

혈액투석 환자에서 발생한 카포시육종의 Pazopanib 치료 증례

  • Chun, You Jin (Department of Internal Medicine, Yonsei University College of Medicine) ;
  • Choi, Ah Ran (Department of Internal Medicine, Yonsei University College of Medicine) ;
  • Yang, Seo Yeon (Department of Internal Medicine, Yonsei University College of Medicine) ;
  • Kim, Hyo Eun (Department of Internal Medicine, Yonsei University College of Medicine) ;
  • Cho, Jang Ho (Department of Internal Medicine, Yonsei University College of Medicine) ;
  • Lim, Jae Yun (Department of Internal Medicine, Yonsei University College of Medicine) ;
  • Cho, Jae Yong (Department of Internal Medicine, Yonsei University College of Medicine)
  • 천유진 (연세대학교 의과대학 내과학교실) ;
  • 최아란 (연세대학교 의과대학 내과학교실) ;
  • 양서연 (연세대학교 의과대학 내과학교실) ;
  • 김효은 (연세대학교 의과대학 내과학교실) ;
  • 조장호 (연세대학교 의과대학 내과학교실) ;
  • 임재윤 (연세대학교 의과대학 내과학교실) ;
  • 조재용 (연세대학교 의과대학 내과학교실)
  • Published : 20150000
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Abstract

Kaposi’s sarcoma (KS) is an unusual multifocal neoplastic angioproliferative disorder. We herein report a case of classic KS that occurred in a patient receiving hemodialysis for 7 years. The patient had a history of chronic renal failure due to glomerulonephritis for 20 years. Multiple reddened violaceous patches, plaques, and nodules were found on the right knee. Biopsy revealed positivity for human herpesvirus 8 (KS-associated herpesvirus) consistent with KS. Pazopanib, a multitarget tyrosine kinase inhibitor, is an effective agent for treatment of advanced soft tissue sarcoma. The patient received pazopanib for 6 months investigate its effects on KS. The skin lesions and painful symptoms showed improvement. Further studies are required to determine the mechanism underlying the anticancer action of pazopanib and the pathogenesis of KS.

현재까지 우리나라에서는 본 증례를 포함해 아주 적은 수의 혈액투석 환자에서의 카포시육종이 보고되었으며, 특히 pazopanib을 첫 치료제로 선택한 경우는 보고된 바가 없다. 저자는 림프절병증을 동반한 카포시육종에서 pazopanib 복용 후 피부 병변 크기 감소 및 통증 완화의 치료 효과 있음을 경험하여 보고하고자 한다.

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