DOI QR코드

DOI QR Code

Coupling Interval Ratio Is Associated with Ventricular Premature Complex-Related Symptoms

  • Park, Kyoung-Min (Division of Cardiology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
  • Im, Sung Il (Division of Cardiology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
  • Chun, Kwang Jin (Division of Cardiology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
  • Hwang, Jin Kyung (Division of Cardiology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
  • Park, Seung-Jung (Division of Cardiology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
  • Kim, June Soo (Division of Cardiology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
  • On, Young Keun (Division of Cardiology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine)
  • Received : 2014.12.25
  • Accepted : 2015.03.17
  • Published : 2015.07.30

Abstract

Background and Objectives: Frequent ventricular premature complex (VPC) is one of the most common arrhythmia syndromes. Symptoms observed frequently with this arrhythmia syndrome remain limited. We sought to identify predictors of VPC-related symptoms by analyzing demographic information, VPC burden, and VPC surface electrocardiogram characteristics. Subjects and Methods: We prospectively enrolled 109 patients with idiopathic outflow tract VPCs (63 males, $49{\pm}16$ years old). They were divided into Group A (n=30, without VPC-related symptoms of palpitations or "dropped beats") and Group B (n=79, with VPC-related symptoms). Measured parameters were sinus and VPC QRS width, coupling interval (CI) between the previous sinus beat and VPC, CI ratio (%, CI/sinus cycle length), post-VPC CI and CI ratio, and VPC amplitude. Results: Both groups had similar age (p=0.22), daily VPC burden (p=0.15), and VPC site of origin (p=0.36). The VPC CI ratio was higher in Group B ($60{\pm}15%$) than in Group A ($49{\pm}22%$) (p=0.01). Conclusion: VPC-related symptoms are associated with a higher VPC CI ratio (>50%). The physiologic basis for these results deserves further study.

Keywords

References

  1. Gaita F, Giustetto C, Di Donna, et al. Long-term follow-up of right ventricular monomorphic extrasystoles. J Am Coll Cardiol 2001;38:364-70. https://doi.org/10.1016/S0735-1097(01)01403-6
  2. Conti CR. Ventricular arrhythmias: a general cardiologist’s assessment of therapies in 2005. Clin Cardiol 2005;28:314-6. https://doi.org/10.1002/clc.4960280702
  3. Ghanbari H, Schmidt M, Machado C, Daccarett M. Catheter ablation of ventricular tachycardia in structurally normal hearts. Expert Rev Cardiovasc Ther 2010;8:651-61. https://doi.org/10.1586/erc.10.25
  4. Wilber DJ. Ventricular ectopic beats: not so benign. Heart 2009;95:1209-10. https://doi.org/10.1136/hrt.2009.166579
  5. Baman TS, Lange DC, Ilg KJ, et al. Relationship between burden of premature ventricular complexes and left ventricular function. Heart Rhythm 2010;7:865-9. https://doi.org/10.1016/j.hrthm.2010.03.036
  6. Sarrazin JF, Labounty T, Kuhne M, et al. Impact of radiofrequency ablation of frequent post-infarction premature ventricular complexes on left ventricular ejection fraction. Heart Rhythm 2009;6:1543-9. https://doi.org/10.1016/j.hrthm.2009.08.004
  7. Yarlagadda RK, Iwai S, Stein KM, et al. Reversal of cardiomyopathy in patients with repetitive monomorphic ventricular ectopy originating from the right ventricular outflow tract. Circulation 2005;112:1092-7. https://doi.org/10.1161/CIRCULATIONAHA.105.546432
  8. Bogun F, Crawford T, Reich S, et al. Radiofrequency ablation of frequent, idiopathic premature ventricular complexes: comparison with a control group without intervention. Heart Rhythm 2007;4:863-7. https://doi.org/10.1016/j.hrthm.2007.03.003
  9. Takemoto M, Yoshimura H, Ohba Y, et al. Radiofrequency catheter ablation of premature ventricular complexes from right ventricular outflow tract improves left ventricular dilation and clinical status in patients without structural heart disease. J Am Coll Cardiol 2005;45:1259-65. https://doi.org/10.1016/j.jacc.2004.12.073
  10. Oh HL, Choue CW, Cho JM, et al. Clinical characteristics of ventricular premature beats originating from right ventricular outflow tract. Korean Circ J 2003;33:1118-25. https://doi.org/10.4070/kcj.2003.33.12.1118
  11. Rolfe SJ, Rasor T, Shaffer PA, Sanitate PA, Bashore TM. Relation between premature ventricular contraction site of origin (defined by radionuclide phase analysis) and subsequent left ventricular function. Am J Cardiol 1984;53:1028-33. https://doi.org/10.1016/0002-9149(84)90631-3
  12. Migliore F, Folino AF, Bilato C, et al. Origin of recurrent syncope in patient with right ventricular outflow tract arrhythmias: evidence of autonomic modulation of the ectopic foci. J Cardiovasc Med 2011;12:598-600. https://doi.org/10.2459/JCM.0b013e328337591d
  13. Chen JY, Tsai WC, Lee YL, et al. Association of premature ventricular complexes with central aortic pressure indices and pulse wave velocity. Am Heart J 2008;155:e1-6. https://doi.org/10.1016/j.ahj.2007.10.011
  14. Huizar JF, Kaszala K, Potfay J, et al. Left ventricular systolic dysfunction induced by ventricular ectopy: a novel model for premature ventricular contraction-induced cardiomyopathy. Circ Arrhythm Electrophysiol 2011;4:543-9. https://doi.org/10.1161/CIRCEP.111.962381
  15. Ban JE, Lee HS, Lee DI, et al. Electrophysiological characteristics related to outcome after catheter ablation of idiopathic ventricular arrhythmia originating from the papillary muscle in the left ventricle. Korean Circ J 2013;43:811-8. https://doi.org/10.4070/kcj.2013.43.12.811
  16. Sun Y, Blom NA, Yu Y, et al. The influence of premature ventricular contractions on left ventricular function in asymptomatic children without structural heart disease: an echocardiographic evaluation. Int J Cardiovasc Imaging 2003;19:295-9. https://doi.org/10.1023/A:1025418531853
  17. Komatsu T, Ikeda K, Tomoike H. Assessment of the variability in coupling intervals of ventricular premature contractions. Jpn Circ J 1993;57:781-8. https://doi.org/10.1253/jcj.57.781
  18. Thanavaro S, Kleiger RE, Miller JP, Province MA, Friedman E, Oliver GC. Coupling interval and types of ventricular ectopic activity associated with ventricular runs. Am Heart J 1983;106:484-91. https://doi.org/10.1016/0002-8703(83)90690-7
  19. Jakopin J, Horvat M, Brucan A, Rode P. The relation of heart rhythm to postextrasystolic potentiation. Bibl Cardiol 1979;164-8.
  20. Otsuji Y, Kisanuki A, Toda H, et al. Influence of left ventricular filling profile during preceding control beats on the occurrence of pulse deficit caused by ventricular premature contractions. Eur Heart J 1993;14:1044-9. https://doi.org/10.1093/eurheartj/14.8.1044
  21. Yellin EL, Kennish A, Yoran C, Laniado S, Buckley NM, Frater RW. The influence of left ventricular filling on postextrasystolic potentiation in the dog heart. Circ Res 1979;44:712-22. https://doi.org/10.1161/01.RES.44.5.712
  22. Eber LM, Berkovits BV, Matloff JM, Gorlin R. Dynamic characterization of premature ventricular beats and ventricular tachycardias. Am J Cardiol 1974;33:378-83. https://doi.org/10.1016/0002-9149(74)90319-1
  23. Millar K, Eich RH, Abildskov JA. Relation of variations in activation order to intraventricular pressures during premature beats. Circ Res 1966;19:481-8. https://doi.org/10.1161/01.RES.19.3.481
  24. Baman TS, Lange DC, Ilg KJ, et al. Relationship between burden of premature ventricular complexes and left ventricular function. Heart Rhythm 2010;7:865-9. https://doi.org/10.1016/j.hrthm.2010.03.036
  25. Sarrazin JF, Labounty T, Kuhne M, et al. Impact of radiofrequency ablation of frequent post-infarction premature ventricular complexes on left ventricular ejection fraction. Heart Rhythm 2009;6:1543-9. https://doi.org/10.1016/j.hrthm.2009.08.004
  26. Efremidis M, Letsas KP, Sideris A, Kardaras F. Reversal of premature ventricular complex-induced cardiomyopathy following successful radio-frequency catheter ablation. Europace 2008;10:769-70. https://doi.org/10.1093/europace/eun060
  27. Mountantonakis SE, Frankel DS, Gerstenfeld EP, et al. Reversal of outflow tract ventricular premature depolarization-induced cardiomyopathy with ablation: effect of residual arrhythmia burden and preexisting cardiomyopathy on outcome. Heart Rhythm 2011;8:1608-14. https://doi.org/10.1016/j.hrthm.2011.04.026

Cited by

  1. Is the stroke volume during post-ectopic beat associated with ventricular premature complex-related symptoms? vol.20, pp.2, 2015, https://doi.org/10.1093/europace/eux170
  2. Left Ventricular Inflow Velocity Pattern in Patients With Symptomatic Premature Ventricular Contraction vol.84, pp.1, 2015, https://doi.org/10.1253/circj.cj-19-0605