Korean Circulation Journal

The Korean Society of Cardiology (대한심장학회)
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Effects of Age, Sex, and Menopausal Status on Blood Cholesterol Profile in the Korean Population

  • Park, Ji Hye (Department of Public Health, Yonsei University Graduate School) ;
  • Lee, Myung Ha (Department of Preventive Medicine, Yonsei University College of Medicine) ;
  • Shim, Jee-Seon (Cardiovascular and Metabolic Diseases Etiology Research Center, Yonsei University College of Medicine) ;
  • Choi, Dong Phil (Department of Public Health, Yonsei University Graduate School) ;
  • Song, Bo Mi (Department of Public Health, Yonsei University Graduate School) ;
  • Lee, Seung Won (Department of Public Health, Yonsei University Graduate School) ;
  • Choi, Hansol (Department of Public Health, Yonsei University Graduate School) ;
  • Kim, Hyeon Chang (Department of Preventive Medicine, Yonsei University College of Medicine)
  • Received : 2014.09.27
  • Accepted : 2014.12.18
  • Published : 2015.03.30
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Abstract

Background and Objectives: To investigate age-specific and sex-specific distributions of blood cholesterol in the general Korean population. Subjects and Methods: We analyzed data for 8284 men and 9246 women aged ${\geq}10years$ who participated in the fifth (2010-2012) Korea National Health and Nutrition Examination Survey. Age-specific means, medians, and selected percentiles were calculated for men, premenopausal women, and postmenopausal women. Results: Median total cholesterol (TC) level increased with age across all age groups, from 147 to 196 mg/dL in males and from 159 to 210 mg/dL in females. Triglyceride (TG) levels increased with age in females; however, in males, TG levels rapidly increased during young adulthood, peaked at 50-54 years, and then decreased. High density lipoprotein-cholesterol (HDL-C) levels were higher in females than in males and decreased with increasing age in both males and females. Low density lipoprotein-cholesterol (LDL-C) levels increased with age across all age groups, from 89 to 127 mg/dL in males and from 82 to 113 mg/dL in females. Lipoprotein-cholesterol fraction (TC/HDL-C, LDL-C/HDL-C, TG/HDL-C, non-HDL-C) levels increased with age in females, but increased more rapidly in males during young adulthood and decreased after middle age. Conclusion: Blood cholesterol levels and lipoprotein-cholesterol fractions present different distributions by age, sex, and menopausal status.

Keywords

Acknowledgement

Supported by : Ministry of Health & Welfare

References

  1. Farzadfar F, Finucane MM, Danaei G, et al. National, regional, and global trends in serum total cholesterol since 1980: systematic analysis of health examination surveys and epidemiological studies with 321 country-years and 3.0 million participants. Lancet 2011;377:578-86. https://doi.org/10.1016/S0140-6736(10)62038-7
  2. Stamler J, Wentworth D, Neaton JD. Is relationship between serum cholesterol and risk of premature death from coronary heart disease continuous and graded? Findings in 356,222 primary screenees of the Multiple Risk Factor Intervention Trial (MRFIT). JAMA 1986;256:2823-8. https://doi.org/10.1001/jama.1986.03380200061022
  3. Natarajan S, Glick H, Criqui M, Horowitz D, Lipsitz SR, Kinosian B. Cholesterol measures to identify and treat individuals at risk for coronary heart disease. Am J Prev Med 2003;25:50-7. https://doi.org/10.1016/S0749-3797(03)00092-8
  4. Gordon DJ, Probstfield JL, Garrison RJ, et al. High-density lipoprotein cholesterol and cardiovascular disease. Four prospective American studies. Circulation 1989;79:8-15. https://doi.org/10.1161/01.CIR.79.1.8
  5. Kinosian B, Glick H, Preiss L, Puder KL. Cholesterol and coronary heart disease: predicting risks in men by changes in levels and ratios. J Investig Med 1995;43:443-50.
  6. Kastelein JJ, van der Steeg WA, Holme I, et al. Lipids, apolipoproteins, and their ratios in relation to cardiovascular events with statin treatment. Circulation 2008;117:3002-9. https://doi.org/10.1161/CIRCULATIONAHA.107.713438
  7. Anderson KM, Wilson PW, Odell PM, Kannel WB. An updated coronary risk profile. A statement for health professionals. Circulation 1991;83:356-62. https://doi.org/10.1161/01.CIR.83.1.356
  8. Hokanson JE, Austin MA. Plasma triglyceride level is a risk factor for cardiovascular disease independent of high-density lipoprotein cholesterol level: a meta-analysis of population-based prospective studies. J Cardiovasc Risk 1996;3:213-9.
  9. Assmann G, Schulte H, Funke H, von Eckardstein A. The emergence of triglycerides as a significant independent risk factor in coronary artery disease. Eur Heart J 1998;19 Suppl M:M8-14.
  10. Malik S, Wong ND, Franklin SS, et al. Impact of the metabolic syndrome on mortality from coronary heart disease, cardiovascular disease, and all causes in United States adults. Circulation 2004;110:1245-50. https://doi.org/10.1161/01.CIR.0000140677.20606.0E
  11. Wannamethee SG, Shaper AG, Lennon L, Morris RW. Metabolic syndrome vs Framingham Risk Score for prediction of coronary heart disease, stroke, and type 2 diabetes mellitus. Arch Intern Med 2005;165:2644-50. https://doi.org/10.1001/archinte.165.22.2644
  12. Gaziano JM, Hennekens CH, O'Donnell CJ, Breslow JL, Buring JE. Fasting triglycerides, high-density lipoprotein, and risk of myocardial infarction. Circulation 1997;96:2520-5. https://doi.org/10.1161/01.CIR.96.8.2520
  13. Packard CJ, Saito Y. Non-HDL cholesterol as a measure of atherosclerotic risk. J Atheroscler Thromb 2004;11:6-14. https://doi.org/10.5551/jat.11.6
  14. Lee MH, Kim HC, Ahn SV, et al. Prevalence of Dyslipidemia among Korean Adults: Korea National Health and Nutrition Survey 1998-2005. Diabetes Metab J 2012;36:43-55. https://doi.org/10.4093/dmj.2012.36.1.43
  15. Roh E, Ko SH, Kwon HS, et al. Prevalence and Management of Dyslipidemia in Korea: Korea National Health and Nutrition Examination Survey during 1998 to 2010. Diabetes Metab J 2013;37:433-49. https://doi.org/10.4093/dmj.2013.37.6.433
  16. Nam GE, Han K, Park YG, et al. Trends in lipid profiles among South Korean adults: 2005, 2008 and 2010 Korea National Health and Nutrition Examination Survey. J Public Health (Oxf) 2014 Feb 25 [Epub]. http://dx.doi.org/10.1093/pubmed/fdu012.
  17. Kweon S, Kim Y, Jang MJ, et al. Data resource profile: the Korea National Health and Nutrition Examination Survey (KNHANES). Int J Epidemiol 2014;43:69-77. https://doi.org/10.1093/ije/dyt228
  18. Friedewald WT, Levy RI, Fredrickson DS. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem 1972;18:499-502.
  19. Castelli WP. Cholesterol and lipids in the risk of coronary artery disease--the Framingham Heart Study. Can J Cardiol 1988;4 Suppl A:5A-10A.
  20. Kosmas CE, Christodoulidis G, Cheng JW, Vittorio TJ, Lerakis S. Highdensity lipoprotein functionality in coronary artery disease. Am J Med Sci 2014;347:504-8. https://doi.org/10.1097/MAJ.0000000000000231
  21. Assmann G, Schulte H, von Eckardstein A, Huang Y. High-density lipoprotein cholesterol as a predictor of coronary heart disease risk. The PROCAM experience and pathophysiological implications for reverse cholesterol transport. Atherosclerosis 1996;124 Suppl:S11-20. https://doi.org/10.1016/0021-9150(96)05852-2
  22. Carroll MD, Kit BK, Lacher DA, Shero ST, Mussolino ME. Trends in lipids and lipoproteins in US adults, 1988-2010. JAMA 2012;308:1545-54. https://doi.org/10.1001/jama.2012.13260
  23. Yano Y, Irie N, Homma Y, et al. High density lipoprotein cholesterol levels in the Japanese. Atherosclerosis 1980;36:173-81. https://doi.org/10.1016/0021-9150(80)90226-9
  24. Turley ML, Skeaff CM, Mann JI, Cox B. The effect of a low-fat, highcarbohydrate diet on serum high density lipoprotein cholesterol and triglyceride. Eur J Clin Nutr 1998;52:728-32. https://doi.org/10.1038/sj.ejcn.1600634
  25. Feinleib M, Garrison RJ, Fabsitz R, et al. The NHLBI twin study of cardiovascular disease risk factors: methodology and summary of results. Am J Epidemiol 1977;106:284-5. https://doi.org/10.1093/oxfordjournals.aje.a112464
  26. Schaefer EJ, Levy RI, Ernst ND, Van Sant FD, Brewer HB Jr. The effects of low cholesterol, high polyunsaturated fat, and low fat diets on plasma lipid and lipoprotein cholesterol levels in normal and hypercholesterolemic subjects. Am J Clin Nutr 1981;34:1758-63. https://doi.org/10.1093/ajcn/34.9.1758
  27. Sanders K, Johnson L, O'Dea K, Sinclair AJ. The effect of dietary fat level and quality on plasma lipoprotein lipids and plasma fatty acids in normocholesterolemic subjects. Lipids 1994;29:129-38. https://doi.org/10.1007/BF02537152
  28. Schaefer EJ, Lamon-Fava S, Cohn SD, et al. Effects of age, gender, and menopausal status on plasma low density lipoprotein cholesterol and apolipoprotein B levels in the Framingham Offspring Study. J Lipid Res 1994;35:779-92.
  29. Granfone A, Campos H, McNamara JR, et al. Effects of estrogen replacement on plasma lipoproteins and apolipoproteins in postmenopausal, dyslipidemic women. Metabolism 1992;41:1193-8. https://doi.org/10.1016/0026-0495(92)90008-X
  30. Hwang YC, Ahn HY, Jeong IK, Ahn KJ, Chung HY. Optimal range of triglyceride values to estimate serum low density lipoprotein cholesterol concentration in Korean adults: the Korea National Health and Nutrition Examination Survey, 2009. J Korean Med Sci 2012;27:1530-5. https://doi.org/10.3346/jkms.2012.27.12.1530

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