Journal of Radiopharmaceuticals and Molecular Probes (대한방사성의약품학회지)
- Volume 1 Issue 1
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- Pages.38-45
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- 2015
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- 2384-1583(pISSN)
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- 2508-3848(eISSN)
DOI QR Code
Diagnosis of fibroadenoma using radiolabeled bladder cancer specific peptide
- Ha, Yeong Su (Department of Molecular Medicine, BK21 Plus KNU Biomedical Convergence Program, Kyungpook National University School of Medicine) ;
- Kwak, Wonjung (Department of Molecular Medicine, BK21 Plus KNU Biomedical Convergence Program, Kyungpook National University School of Medicine) ;
- Lee, Hwa Young (Department of Molecular Medicine, BK21 Plus KNU Biomedical Convergence Program, Kyungpook National University School of Medicine) ;
- Lee, Byung-Heon (Department of Biochemistry and Cell Biology and Cell & Matrix Research Institute, Kyungpook National University School of Medicine) ;
- Hong, Il-Hwa (Department of Pathology, College of Veterinary Medicine, Kyungpook National University) ;
- Jeong, Kyu-Shik (Department of Pathology, College of Veterinary Medicine, Kyungpook National University) ;
- An, Gwang Il (Molecular Imaging Research Center, Korea Institute of Radiological and Medical Sciences Seoul) ;
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Yoo, Jeongsoo
(Department of Molecular Medicine, BK21 Plus KNU Biomedical Convergence Program, Kyungpook National University School of Medicine)
- Received : 2015.02.25
- Accepted : 2015.03.31
- Published : 2015.04.30
Abstract
Most tumors are believed to overexpress several receptors, and small peptides targeting these receptors were developed for diagnosis and tumor therapy during past decade. Here we report that fibroadenoma can be visualized by bladder cancer specific peptide. A 9-mer bladder cancer specific peptide, which was discovered from the phage display method, was synthesized by peptide synthesizer, and additional tyrosine was conjugated at the N-terminal for radioiodination (Y-BP). Y-BP was radiolabeled with
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