Journal of Radiopharmaceuticals and Molecular Probes (대한방사성의약품학회지)

Korean Society of Radiopharmaceuticals and Molecular Probes (대한방사성의약품학회)
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Strain-promoted alkyne-azide cycloaddition for PET molecular imaging study

  • Jeong, Hyeon Jin (Department of Chemistry and Chemical Engineering, Inha University) ;
  • Kim, Dong Wook (Department of Chemistry and Chemical Engineering, Inha University)
  • Received : 2015.03.13
  • Accepted : 2015.03.26
  • Published : 2015.04.30
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Abstract

$^{18}F$-labeling reaction of bioactive molecule via click chemistry is widely used to produce $^{18}F$-labeled radiotracer in the field of radiopharmaceutical science and molecular imaging. In particular, bioorthogonal strain-promoted alkyne-azide cycloaddition (SPAAC) reaction has received much attention as an alternative ligation method for radiolabeling bioactive molecules such as peptides, DNA, proteins as well as nanoparticles. Moreover, SPAAC based pretargeting method could provide tumor images successfully on positron emission tomography system using nanoparticle such as mesoporous silica nanoparticles.

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