Asian Pacific Journal of Cancer Prevention

Asian Pacific Journal of Cancer Prevention (아시아태평양암예방학회)
권호 표지
DOI QR코드

DOI QR Code

Molecular Screening for P53 Mutations among Tobacco Smokers in a Surveyof Awareness of Links between Tobacco, Alcohol Use and Cancer in Saudi Arabia

  • Alshammari, Fawaz D (Department of Clinical Laboratory Science, College of Applied Medical Science, University of Hail)
  • Published : 2015.11.04
Download PDF
⟨ Previous Next ⟩

Abstract

Background: Roles of tobacco and alcohol use in etiology of cancer are well established. Alterationin in P53 have essential roles neoplastic change by preventing genome mutation; the aim of this study was to assess the association between P53 mutation and tobacco and alcohol consumption, as well as to assess the epidemiology of tobacco and alcohol use as risk factors for cancer in the adult population of northern Saudi civilians. Materials and Methods: A cross-sectional survey from October 2014 to January 2015, covering 3,398 adults, was performed. P53 mutation molecular detection was performed for 100 tobacco and alcohol users, usingDNA extracted from buccal cells. Results: Of the 3,398 participants 3,253/3398(95.7%) responded, with a male female ratio of 1.10: 1.00. Out of these, 24.8% had smoked tobacco in their lifetime and 2.7% were consumers of alcoholic beverages. None was identified with any P53 mutation. Conclusions: The prevalence of tobacco smoking among the northern Saudi civilians was relatively high. Females' attitudes in tobacco and alcohol related issues were found to be affected by social stigma. Tobacco and alcohol use has no link to P53 gene mutations.

Keywords

References

  1. Alshammari FD, Khalifa AM, Kosba AA, et al (2015). Assessment of perception of medical students in regard to links between tobacco or alcohol use and cancer. Asian Pac J Cancer Prev, 16, 2697-700. https://doi.org/10.7314/APJCP.2015.16.7.2697
  2. Babiker AYY, Abas IMK, Alzohairy MA, Ahmed HG (2012). Assessment of Lung Cytological Atypia among Shisha Smokers. ISRN Pathology; Volume 2012, 676390.
  3. Begg S, Vos T, Barker B, et al (2007). The burden of disease and injury in Australia 2003. PHE 82. Canberra: AIHW.
  4. Bobak M, Jha P, Son N, Jarvis M (2000). In: Oxford medical publications. Jha P, Chaloupka F, editor. Oxford;New York: Oxford University Press. Poverty and smoking; p. 41.
  5. Bobak M, Jha P, Son N, Jarvis M (2000). In: Oxford medical publications. Jha P, Chaloupka F, editor. Oxford;New York: Oxford University Press. Poverty and smoking; p. 41.
  6. Gerd P Pfeifer, Mikhail F Denissenko, Magali Olivier, Natalia Tretyakova, Stephen S Hecht and Pierre Hainaut (2002). Tobacco smoke carcinogens, DNA damage and p53 mutations in smoking-associated cancers. Oncogene ; 21(48): 7435-7451. https://doi.org/10.1038/sj.onc.1205803
  7. Ginawi IG ( 2013). Perception on the relationship between cancer and usage of tobacco and alcohol in hail, Saudi Arabia. J Clin Diagnostic Res, 7, 2197-9.
  8. Haytham M Hassan, Samy S Mahmoud, Mansour K Gatasha, et al (2014). Tobacco smoking among students of Al-ghad College for applied medical sciences for male in riyadh, Saudi Arabia. Int J Biol Med Res, 5, 4468-72.
  9. Jarallah JS, al-Rubeaan KA, al-Nuaim AR (1999). Prevalence and determinants of smoking in three regions of Saudi Arabia. Tob Control, 8, 53-6. https://doi.org/10.1136/tc.8.1.53
  10. Laaksonen M, Rahkonen O, Karvonen S, Lahelma E (2005). Socioeconomic status and smoking: analysing inequalities with multiple indicators. Eur J Public Health, 15, 262-9 https://doi.org/10.1093/eurpub/cki115
  11. Lopez AD, Mathers CD, Ezzati M, Jamison DT, Murray CJ (2006). Global and regional burden of disease and risk factors, 2001: systematic analysis of population health data. Lancet, 367, 1747-57. https://doi.org/10.1016/S0140-6736(06)68770-9
  12. Office of the Surgeon General (2004). National center for chronic disease prevention and health promotion (u.s.) the health consequences of smoking a report of the surgeon general. [atlanta, ga.]: u.s. public health service, national center for chronic disease prevention and health promotion. http://www.surgeongeneral.gov/library/smoking consequences (accessed Jun 2011).
  13. Ronchetti D, Neglia CB, Cesana BM, et al (2004). Association between p53 gene mutations and tobacco and alcohol exposure in laryngeal squamous cell carcinoma. Arch Otolaryngol Head Neck Surg, 130, 303-6. https://doi.org/10.1001/archotol.130.3.303
  14. Saeed AA, Khoja TA, Khan SB (1996). Smoking behavior and attitudes among adult saudi nationals in riyadh City, Saudi Arabia. Tob Control, 5, 215-9. https://doi.org/10.1136/tc.5.3.215
  15. Santanu G, Amrita S, Shuvankar M (2012). Patterns of alcohol consumption among male adults at a slum in Kolkata, India. J Health Popul Nutr, 30, 73-81.
  16. Sasco AJ, Secretan MB, Straif K (2004). Tobacco smoking and cancer: a brief review of recent epidemiological evidence. Lung Cancer, 45, 3-9.
  17. WHO (2002). The world health report 2002-reducing risks, promoting healthy life. Geneva: World Health Organization, 250.
  18. Wipfli H, Samet JM (2009). Global economic and health benefits of tobacco control: part1. Clin Pharmacol Ther, 86, 263-71. https://doi.org/10.1038/clpt.2009.93
  19. World Health Organization (WHO) (2008)., Research for International Tobacco Control. WHO report on the global tobacco epidemic, 2008: the MPOWER package. Geneva: World Health Organization. http://www.who.int/tobacco/mpower/mpower_report_full_2008.

Cited by

  1. p53 pathway determines the cellular response to alcohol-induced DNA damage in MCF-7 breast cancer cells vol.12, pp.4, 2017, https://doi.org/10.1371/journal.pone.0175121