Asian Pacific Journal of Cancer Prevention

Asian Pacific Journal of Cancer Prevention (아시아태평양암예방학회)
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Survivin as a Potential Target for Cancer Therapy

  • Soleimanpour, Elaheh (Department of Genetics, Faculty of Natural Sciences, University of Tabriz) ;
  • Babaei, Esmaeil (Department of Genetics, Faculty of Natural Sciences, University of Tabriz)
  • Published : 2015.10.06
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Abstract

In 1997 for the first time, survivin was described by Amborsini et al. as an anti-apoptotic protein. Subsequent studies revealed that survivin is a multifunctional protein that plays critical roles in several crucial cell processes such as apoptosis, cell cycle, chromosome movement, mitosis and cellular stress responses. Moreover, it's overexpression in cancer cells versus normal cells is associated with chemotherapy resistance, increased tumor recurrence, and shorter patient survival. All of these features make survivin a promising target for cancer therapy. Here, we review the potential characteristics of survivin as a tumor marker.

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References

  1. Altieri DC (1994). Molecular cloning of effector cell protease receptor-1, a novel cell surface receptor for the protease factor Xa. J Biol Chem, 269, 3139-42.
  2. Altieri DC (2008). Survivin, cancer networks and pathwaydirected drug discovery. Nat Rev Cancer, 8, 61-70. https://doi.org/10.1038/nrc2293
  3. Altieri DC (2013). Targeting surviving in cancer. Cancer Letters, 332, 225-8. https://doi.org/10.1016/j.canlet.2012.03.005
  4. Asanuma K, Moriai R, Yajima T, et al (2000). Survivin as a radioresistance factor in pancreatic cancer. Jpn J Cancer Res, 91, 1204-9. https://doi.org/10.1111/j.1349-7006.2000.tb00906.x
  5. Azuhata T, Scott D, Griffith TS, Miller M, Sandler AD (2006). Survivin inhibits apoptosis induced by TRAIL, and the ratio between survivin and TRAIL receptors is predictive of recurrent disease in neuroblastoma. J Pediatr Surg, 41, 1431-40. https://doi.org/10.1016/j.jpedsurg.2006.04.020
  6. Babaei E, Mowla SJ, Shariat Torbaghan S, Emadi Baygi M (2006). Detection of surviving gene expression in formalinfixed paraffin-embedded tissue of human osteosarcoma: its potential usefulness in diagnosis and prognosis of bone tumors. IBJ, 10, 39-45.
  7. Barrett RM, Osborne TP, Wheatley SP (2009). Phosphorylation of survivin at threonine 34 inhibits its mitotic function and enhances its cytoprotective activity. Cell Cycle, 8, 278-83. https://doi.org/10.4161/cc.8.2.7587
  8. Caldas H, Fangusaro JR, Boue DR, Holloway MP, Altura RA (2007). Dissecting the role of endothelial survivin ${\Delta}Ex3$ in angiogenesis. Blood, 109, 1479-89. https://doi.org/10.1182/blood-2006-02-003749
  9. Carrasco RA, Stamm NB, Marcusson E, et al (2011). Antisense inhibition of surviving expression as a cancer therapeutic. Mol Cancer Ther, 10, 221-32. https://doi.org/10.1158/1535-7163.MCT-10-0756
  10. Carter BZ, Mak DH, Schober WD, et al (2006). Regulation of survivin expression through Bcr-Abl/MAPK cascade: Targeting survivin overcomes imatinib resistance and increases imatinib sensitivity in imatinib-responsive CML cells. Blood, 107, 1555-63. https://doi.org/10.1182/blood-2004-12-4704
  11. Castro-Gamero AM, Borges KS, et al (2013). Tetra-Omethyl nordihydroguaiaretic acid, an inhibitor of Sp1-mediated survivin transcription, induces apoptosis and acts synergistically with chemo-radiotherapy in glioblastoma cells. Invest New Drugs, 31, 858-70 https://doi.org/10.1007/s10637-012-9917-4
  12. Cheng Q, Ling X, Haller A, et al (2012). Suppression of survivin promoter activity by YM155 involves disruption of Sp1-DNA interaction in the survivin core promoter. Int J Biochem Mol Biol, 3, 179-97.
  13. Cheng Z, Hu L, Fu W, Zhang Q, Liao X (2007). Expression of survivin and its splice variants in gastric cancer. J Huazhong Univ Sci Technolog Med Sci, 27, 393-8. https://doi.org/10.1007/s11596-007-0411-8
  14. Cheung CH, Sun X, Kanwar JR, et al (2010). A cell-permeable dominant-negative survivin protein induces apoptosis and sensitizes prostate cancer cells to TNF alpha therapy. Cancer Cell Int, 10.
  15. Colnaghi R, Wheatley SP (2010). Liaisons between survivin and Plk1 during cell division and cell death. J Biol Chem, 285, 22592-604. https://doi.org/10.1074/jbc.M109.065003
  16. Coumar M, Tsai F, Kanwar JR, Sarvagalla S, Cheung CH (2013). Treat cancers by targeting survivin: Just a dream or future reality? Cancer Treatment Reviews, 39, 802-11. https://doi.org/10.1016/j.ctrv.2013.02.002
  17. Croci DO, Cogno IS, Vittar NB, et al (2008). Silencing survivin gene expression promotes apoptosis of human breast cancer cells through a caspase-independent pathway. J Cell Biochem, 105, 381-90. https://doi.org/10.1002/jcb.21836
  18. Fisker N, Westergaard M, Hansen HF, Hansen JB (2007). Survivin mRNA antagonists using locked nucleic acid, potential for molecular cancer therapy. Nucleosides Nucleotides Nucleic Acids, 26, 1427-30. https://doi.org/10.1080/15257770701542132
  19. Hansen JB, Fisker N, Westergaard M, et al (2008). SPC3042: a proapoptotic surviving inhibitor. Mol Cancer Ther, 7, 2736-45. https://doi.org/10.1158/1535-7163.MCT-08-0161
  20. Jiang Y, Saavedra HI, Holloway MP, Leone G, Altura RA (2004). Aberrant regulation of survivin by the RB/E2F family of proteins. J Biol Chem, 279, 40511-20 https://doi.org/10.1074/jbc.M404496200
  21. Kanwar JR, Shen WP, Kanwar RK, Berg RW, Krissansen GW (2001). Effects of surviving antagonists on growth of established tumors and B7-1 immunogene therapy. J Natl Cancer Inst, 93, 1541-52. https://doi.org/10.1093/jnci/93.20.1541
  22. Kanwar JR, Kamalapuram SK, Kanwar RK (2013). Survivin signaling in clinical oncology: a multifaceted dragon. Med Res Rev, 33, 765-89. https://doi.org/10.1002/med.21264
  23. Kyani K, Babaei E, Hosseinpour feizi MA, et al (2014). Detection of surviving $2{\alpha}$ gene expression in thyroid nodules. J Cancer Res Ther, 10, 312-6. https://doi.org/10.4103/0973-1482.136598
  24. Lens SM, Vader G, Medema RH (2006). The case for survivin as mitotic regulator. Curr Opin Cell Biol, 18, 616-22. https://doi.org/10.1016/j.ceb.2006.08.016
  25. Li F, Ambrosini G, Chu EY, et al (1998). Control of apoptosis and mitotic spindle checkpoint by survivin. Nature, 396, 580-4. https://doi.org/10.1038/25141
  26. Li F (2014). Anticancer drug FL118 is more than a survivin inhibitor: where is the Achilles' heel of cancer? Am J Cancer Res, 4, 304-11.
  27. Ling X, Calinski D, Chanan-Khan AA, Zhou M, Li F (2010). Cancer cell sensitivity to bortezomib is associated with survivin expression and p53 status but not cancer cell types. J Exp Clin Cancer Res, 29, 8. https://doi.org/10.1186/1756-9966-29-8
  28. Ling X, Cao SS, QY, et al (2012). A novel small molecule FL118 that selectively inhibits survivin, Mcl-1, XIAP and cIAP2 in a p53-independent manner shows superior antitumor activity. PLoS One, 7.
  29. Liu JL, Wang Y, Jiang J, et al (2010). Inhibition of survivin expression and mechanisms of reversing drug-resistance of human lung adenocarcinoma cells by siRNA. Chin Med J, 123, 2901-7.
  30. Mesri M, Wall NR, Li J, Kim RW, Altieri DC (2001). Cancer gene therapy using a surviving mutant adenovirus. J Clin Invest, 108, 981-90. https://doi.org/10.1172/JCI200112983
  31. Mirza A, McGuirk M, Hockenberry TN, et al (2002). Human survivin is negatively regulated by wild-type p53 and participates in p53-dependent apoptotic pathway. Oncogene, 21, 2613-22. https://doi.org/10.1038/sj.onc.1205353
  32. Mita AC, Mita MM, Nawrocki ST, Giles FJ (2008). Survivin: key regulator of mitosis and apoptosis and novel target for cancer therapeutics. Clin Cancer Res, 14, 5000-5. https://doi.org/10.1158/1078-0432.CCR-08-0746
  33. Mobahat M, Narendran A, Riabowol K (2014). Survivin as a preferential target for cancer therapy. Int J Mol Sci, 15, 2494-516. https://doi.org/10.3390/ijms15022494
  34. Mohamed S, Yasufuku K, Nakajima T, et al (2009). Nuclear survivin in pN2 nonsmall cell lung cancer: Prognostic and clinical implications. Eur Respir J, 33, 127-33. https://doi.org/10.1183/09031936.00068708
  35. Na YS, Yang SJ, Kim SM, et al (2012). YM155 induces EGFR suppression in pancreatic cancer cell. PLoS ONE, 7, 38625. https://doi.org/10.1371/journal.pone.0038625
  36. Nakahara T, Kita A, Yamanaka K, et al (2012). Broad spectrum and potent antitumor activities of YM155, a novel smallmolecule survivin suppressant, in a wide variety of human cancer cell lines and xenograft models. Cancer Sci, 102, 614-21.
  37. Nouraee N, Mowla SJ, Ozhand A, et al (2009). Expression of Survivin and Its Spliced Variants in Bladder Tumors as a Potential Prognostic Marker. Urol J, 6, 101-8.
  38. O'Connor DS, Grossman D, Plescia J, et al (2000). Regulation of apoptosis at cell division by p34cdc2 phosphorylation of survivin. Proc Nat Acad Sci, 97, 13103-7. https://doi.org/10.1073/pnas.240390697
  39. Olie RA, Simoes-Wust AP, Baumann B, et al (2000). A novel antisense oligonucleotide targeting survivin expression induces apoptosis and sensitizes lung cancer cells to chemotherapy. Cancer Res, 60, 2805-9.
  40. Ouyang L, Shi Z, Zhao S, et al (2012). Programmed cell death pathways in cancer: a review of apoptosis, autophagy and programmed necrosis. Cell Prolif, 45, 487-98. https://doi.org/10.1111/j.1365-2184.2012.00845.x
  41. Pavlyukov MS, Antipova NV, Balashova MV, et al (2011). Survivin monomer plays an essential role in apoptosis regulation. J Biol Chem, 286, 23296-307. https://doi.org/10.1074/jbc.M111.237586
  42. Pennati M, Binda M, Colella G, et al (2003). Radiosensitization of human melanoma cells by ribozyme-mediated inhibition of surviving expression. J Invest Dermatol, 120, 648-54. https://doi.org/10.1046/j.1523-1747.2003.12082.x
  43. Plescia J, Salz W, Xia F, et al (2005). Rational design of shepherdin, a novel anticancer agent. Cancer Cell, 7, 457-68. https://doi.org/10.1016/j.ccr.2005.03.035
  44. Poomsawat S, Punyasingh J, Vejchapipat P (2014). Overexpression of survivin and caspase 3 in oral carcinogenesis. Appl Immunohistochem Mol Morphol, 22, 65-71. https://doi.org/10.1097/PAI.0b013e31828a0d0c
  45. Rodel C, Haas J, Groth A, et al (2003). Spontaneous and radiation-induced apoptosis in colorectal carcinoma cells with different intrinsic radiosensitivities: Survivin as a radioresistance factor. Int J Radiat Oncol Biol Phys, 55, 1341-7. https://doi.org/10.1016/S0360-3016(02)04618-7
  46. Sah NK, Munshi A, Hobbs M, et al (2006). Effect of downregulation of survivin expression on radiosensitivity of human epidermoid carcinoma cells. Int J Radiat Oncol Biol Phys, 66, 852-9. https://doi.org/10.1016/j.ijrobp.2006.06.049
  47. Shariat SF, Casella R, Khoddami SM, et al (2004). Urine detection of survivin is a sensitive marker for the noninvasive diagnosis of bladder cancer. J Urol, 171, 626-30. https://doi.org/10.1097/01.ju.0000107826.78479.90
  48. Sharma H, Sen S, Lo Muzio L, Mariggio A, Singh N (2005). Antisense-mediated downregulation of anti-apoptotic proteins induces apoptosis and sensitizes head and neck squamous cell carcinoma cells to chemotherapy. Cancer Biol Ther, 4, 720-7. https://doi.org/10.4161/cbt.4.7.1783
  49. Shin S, Sung BJ, Cho YS, et al (2001). An anti-apoptotic protein human survivin is a direct inhibitor of caspase-3 and -7. Biochemistry, 40, 1117-23. https://doi.org/10.1021/bi001603q
  50. Sommer KW, Schamberger CJ, Schmidt GE, Sasgary S, Cerni C (2003). Inhibitor of apoptosis protein (IAP) survivin is upregulated by oncogenic c-H-Ras. Oncogene, 22, 4266-80. https://doi.org/10.1038/sj.onc.1206509
  51. Sung B-J, Cho Y-S, Kim H-J, et al (2001). An anti-apoptotic protein human survivin is a direct inhibitor of caspase-3 and -7. Biochemistry, 40, 1117-23. https://doi.org/10.1021/bi001603q
  52. Tamm I, Wang Y, Sausville E, et al (1998). IAP-family protein survivin inhibits caspase activity and apoptosis induced by Fas (CD95), Bax, caspases, and anticancer drugs. Cancer Res, 58, 5315-20
  53. Tran J, Master Z, Yu JL, et al (2002). A role for survivin in chemoresistance of endothelial cells mediated by VEGF. Proc Natl Acad Sci U S A, 99, 4349-54. https://doi.org/10.1073/pnas.072586399
  54. Tu SP, Jiang XH, Lin MC, et al (2003). Suppression of survivin expression inhibits in vivo tumorigenicity and angiogenesis in gastric cancer. Cancer Res, 63, 7724-32.
  55. Vandghanooni S, Eskandani M, Montazeri V, et al (2011). Survivin-delta Ex3: a novel biomarker for diagnosis of papillary thyroid carcinoma. J cancer Res Ther, 7, 325-30. https://doi.org/10.4103/0973-1482.87038
  56. Yamamoto T, Manome Y, Nakamura M, Tanigawa N (2002). Downregulation of surviving expression by induction of the effector cell protease receptor-1 reduces tumor growth potential and results in an increased sensitivity to anticancer agents in human colon cancer. Eur J Cancer, 38, 2316-24. https://doi.org/10.1016/S0959-8049(02)00247-2
  57. Yamashita SI, Masuda Y, Kurizaki T, et al (2007). Survivin expression predicts early recurrencein early-stage breast cancer. Anticancer Res, 27, 2803-8.
  58. Yong-Gang Lv, Fang Yu, Qing Yao, Jiang-Hao Chen, Ling Wang (2010). The role of survivin in diagnosis, prognosis and treatment of breast cancer. J Thorac Dis, 2, 100-10.
  59. You L, He B, Xu Z, et al (2004). InhibitionofWnt-2-mediated signaling induces programmed cell death in nonsmall- cell lung cancer cells. Oncogene, 23, 6170-74. https://doi.org/10.1038/sj.onc.1207844
  60. Zhang MC, Hu CP, Chen Q (2006). Effect of down-regulation of survivin gene on apoptosis and cisplatin resistance in cisplatin resistant human lung adenocarcinoma A549/CDDP cells. Zhonghua Zhong Liu Za Zhi, 28, 408-12.
  61. Ziaee SA, Moula SJ, Hosseini Moghaddam SM, Eskandar-Shiri D (2006). Diagnosis of bladder cancer by urine survivin, an inhibitor of apoptosis. Urol J, 3, 150-3.

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