Journal of the Korean Association of Oral and Maxillofacial Surgeons

The Korean Association of Oral and Maxillofacial Surgeons (대한구강악안면외과학회)
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Aplastic anemia and dental implant rehabilitation: a clinical trial

  • Kim, Jun-Hwa (Department of Oral and Maxillofacial Surgery, School of Dentistry, Chonnam National University) ;
  • Shet, Uttom Kumar (Department of Oral and Maxillofacial Surgery, School of Dentistry, Chonnam National University) ;
  • Kim, Byeong-Guk (Department of Oral and Maxillofacial Surgery, School of Dentistry, Chonnam National University) ;
  • Kim, Myung-In (Department of Oral and Maxillofacial Surgery, School of Dentistry, Chonnam National University) ;
  • Kook, Min-Suk (Department of Oral and Maxillofacial Surgery, School of Dentistry, Chonnam National University) ;
  • Oh, Hee-Kyun (Department of Oral and Maxillofacial Surgery, School of Dentistry, Chonnam National University) ;
  • Ryu, Sun-Youl (Department of Oral and Maxillofacial Surgery, School of Dentistry, Chonnam National University) ;
  • Park, Hong-Ju (Department of Oral and Maxillofacial Surgery, School of Dentistry, Chonnam National University) ;
  • Jung, Seunggon (Department of Oral and Maxillofacial Surgery, School of Dentistry, Chonnam National University)
  • Received : 2015.05.04
  • Accepted : 2015.09.25
  • Published : 2015.10.31
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Abstract

The purpose of this study was to investigate implant-supported restoration as a technique for restoring missing teeth in patients with aplastic anemia. Recurrent bleeding from wound sites leads to persistent release of iron in the tissue. Excessive iron in tissue is related to clinical findings, including fibrosis, poor wound healing, and high level of angiogenesis, which are possible etiological factors of reduced osseointegration. A 44-year-old female patient with aplastic anemia was treated with multiple endosseous implants throughout the mandible and in the posterior region of the maxilla. After 14 implants were placed, radiological and clinical parameters were assessed during the follow-up period. Marginal bone did not change significantly during the follow-up period. The fine trabecular bone in intimate contact and enclosing the implant fixture was sufficient for successful osseointegration. None of the 14 implants were associated with compilations during the seven-year experimental period. This study suggests that dental implant procedures are a safe and reliable treatment option for restoration of missing dentition in patients with aplastic anemia.

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References

  1. Hoffman M, Harger A, Lenkowski A, Hedner U, Roberts HR, Monroe DM. Cutaneous wound healing is impaired in hemophilia B. Blood 2006;108:3053-60. https://doi.org/10.1182/blood-2006-05-020495
  2. Esposito M, Thomsen P, Ericson LE, Lekholm U. Histopathologic observations on early oral implant failures. Int J Oral Maxillofac Implants 1999;14:798-810.
  3. Young NS. Acquired aplastic anemia. Ann Intern Med 2002;136:534-46. https://doi.org/10.7326/0003-4819-136-7-200204020-00011
  4. Vincent PC. Drug-induced aplastic anaemia and agranulocytosis. Incidence and mechanisms. Drugs 1986;31:52-63. https://doi.org/10.2165/00003495-198631010-00004
  5. Betticher DC, Wolfisberg HP, Krapf R. Aplastic anemia in carbamazepine therapy. Schweiz Med Wochenschr 1991;121:583-8.
  6. Muir KR, Chilvers CE, Harriss C, Coulson L, Grainge M, Darbyshire P, et al. The role of occupational and environmental exposures in the aetiology of acquired severe aplastic anaemia: a case control investigation. Br J Haematol 2003;123:906-14. https://doi.org/10.1046/j.1365-2141.2003.04718.x
  7. Honkaniemi E, Gustafsson B, Fischler B, Nemeth A, Frost BM, Papadogiannakis N, et al. Acquired aplastic anaemia in seven children with severe hepatitis with or without liver failure. Acta Paediatr 2007;96:1660-4. https://doi.org/10.1111/j.1651-2227.2007.00491.x
  8. Safadi R, Or R, Ilan Y, Naparstek E, Nagler A, Klein A, et al. Lack of known hepatitis virus in hepatitis-associated aplastic anemia and outcome after bone marrow transplantation. Bone Marrow Transplant 2001;27:183-90. https://doi.org/10.1038/sj.bmt.1702749
  9. Sepulveda E, Brethauer U, Rojas J, Le Fort P. Oral manifestations of aplastic anemia in children. J Am Dent Assoc 2006;137:474-8. https://doi.org/10.14219/jada.archive.2006.0219
  10. Storb R, Thomas ED, Buckner CD, Clift RA, Fefer A, Fernando LP, et al. Allogeneic marrow grafting for treatment of aplastic anemia: a follow-up on long-term survivors. Blood 1976;48:485-90.
  11. Camitta BM, Storb R, Thomas ED. Aplastic anemia (second of two parts): pathogenesis, diagnosis, treatment, and prognosis. N Engl J Med 1982;306:712-8. https://doi.org/10.1056/NEJM198203253061204
  12. McDonald A, Hoffman M, Hedner U, Roberts HR, Monroe DM. Restoring hemostatic thrombin generation at the time of cutaneous wounding does not normalize healing in hemophilia B. J Thromb Haemost 2007;5:1577-83. https://doi.org/10.1111/j.1538-7836.2007.02647.x
  13. Castellanos-Cosano L, Nunez-Vazquez RJ, Segura-Egea JJ, Torres-Lagares D, Corcuera-Flores JR, Machuca-Portillo G. Protocol for oral implant rehabilitation in a hemophilic HIV-positive patient with type C hepatitis. Implant Dent 2014;23:622-5. https://doi.org/10.1097/ID.0000000000000145
  14. Albrektsson T, Zarb G, Worthington P, Eriksson AR. The long-term efficacy of currently used dental implants: a review and proposed criteria of success. Int J Oral Maxillofac Implants 1986;1:11-25.
  15. Misch CE, Perel ML, Wang HL, Sammartino G, Galindo-Moreno P, Trisi P, et al. Implant success, survival, and failure: the International Congress of Oral Implantologists (ICOI) Pisa Consensus Conference. Implant Dent 2008;17:5-15. https://doi.org/10.1097/ID.0b013e3181676059