Asian-Australasian Journal of Animal Sciences

Asian Australasian Association of Animal Production Societies (아세아태평양축산학회)
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A Genome-wide Scan for Selective Sweeps in Racing Horses

  • Moon, Sunjin (Department of Agricultural Biotechnology and Research Institute for Agriculture and Life Sciences, Seoul National University) ;
  • Lee, Jin Woo (Horse Registry, Korea Racing Authority (KRA)) ;
  • Shin, Donghyun (Department of Agricultural Biotechnology and Research Institute for Agriculture and Life Sciences, Seoul National University) ;
  • Shin, Kwang-Yun (Institute for Livestock Promotion) ;
  • Kim, Jun (Institute for Livestock Promotion) ;
  • Choi, Ik-Young (Genome analysis center, National Instrumentation and Environmental Management (NICEM), Seoul National University) ;
  • Kim, Jaemin (Interdisciplinary Program in Bioinformatics, Seoul National University) ;
  • Kim, Heebal (Department of Agricultural Biotechnology and Research Institute for Agriculture and Life Sciences, Seoul National University)
  • Received : 2014.09.08
  • Accepted : 2015.02.22
  • Published : 2015.11.01
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Abstract

Using next-generation sequencing, we conducted a genome-wide scan of selective sweeps associated with selection toward genetic improvement in Thoroughbreds. We investigated potential phenotypic consequence of putative candidate loci by candidate gene association mapping for the finishing time in 240 Thoroughbred horses. We found a significant association with the trait for Ral GApase alpha 2 (RALGAP2) that regulates a variety of cellular processes of signal trafficking. Neighboring genes around RALGAP2 included insulinoma-associated 1 (INSM1), pallid (PLDN), and Ras and Rab interactor 2 (RIN2) genes have similar roles in signal trafficking, suggesting that a co-evolving gene cluster located on the chromosome 22 is under strong artificial selection in racehorses.

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References

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