Biomolecules & Therapeutics

  • 제23권6호
  • /
  • Pages.510-516
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  • 2015
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  • 1976-9148(pISSN)
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  • 2005-4483(eISSN)
한국응용약물학회 (The Korean Society of Applied Pharmacology)
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Lipid A as a Drug Target and Therapeutic Molecule

  • Joo, Sang Hoon (Laboratory of Biochemistry, College of Pharmacy, Catholic University of Daegu)
  • 투고 : 2015.08.02
  • 심사 : 2015.10.05
  • 발행 : 2015.11.01
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초록

In this review, lipid A, from its discovery to recent findings, is presented as a drug target and therapeutic molecule. First, the biosynthetic pathway for lipid A, the Raetz pathway, serves as a good drug target for antibiotic development. Several assay methods used to screen for inhibitors of lipid A synthesis will be presented, and some of the promising lead compounds will be described. Second, utilization of lipid A biosynthetic pathways by various bacterial species can generate modified lipid A molecules with therapeutic value.

키워드

참고문헌

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