The Korean journal of internal medicine

The Korean Association of Internal Medicine (대한내과학회)
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Infections after lung transplantation: time of occurrence, sites, and microbiologic etiologies

  • Yun, Ji Hyun (Department of Infectious Diseases, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Lee, Sang-Oh (Department of Infectious Diseases, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Jo, Kyung-Wook (Department of Pulmonology and Critical Care Medicine, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Choi, Se Hoon (Department of Thoracic and Cardiovascular Surgery, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Lee, Jina (Department of Pediatrics, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Chae, Eun Jin (Department of Radiology, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Do, Kyung-Hyun (Department of Radiology, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Choi, Dae-Kee (Department of Anesthesiology and Pain Medicine, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Choi, In-Cheol (Department of Anesthesiology and Pain Medicine, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Hong, Sang-Bum (Department of Pulmonology and Critical Care Medicine, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Shim, Tae Sun (Department of Pulmonology and Critical Care Medicine, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Kim, Hyeong Ryul (Department of Thoracic and Cardiovascular Surgery, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Kim, Dong Kwan (Department of Thoracic and Cardiovascular Surgery, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Park, Seung-Il (Department of Thoracic and Cardiovascular Surgery, Asan Medical Center, University of Ulsan College of Medicine)
  • Received : 2014.12.26
  • Accepted : 2015.03.30
  • Published : 2015.07.01
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Abstract

Background/Aims: Infections are major causes of both early and late death after lung transplantation (LT). The development of prophylaxis strategies has altered the epidemiology of post-LT infections; however, recent epidemiological data are limited. We evaluated infections after LT at our institution by time of occurrence, site of infections, and microbiologic etiologies. Methods: All consecutive patients undergoing lung or heart-lung transplantation between October 2008 and August 2014 at our institution were enrolled. Cases of infections after LT were initially identified from the prospective registry database, which was followed by a detailed review of the patients' medical records. Results: A total of 108 episodes of post-LT infections (56 bacterial, 43 viral, and nine fungal infections) were observed in 34 LT recipients. Within 1 month after LT, the most common bacterial infections were catheter-related bloodstream infections (42%). Pneumonia was the most common site of bacterial infection in the 2- to 6-month period (28%) and after 6 months (47%). Cytomegalovirus was the most common viral infection within 1 month (75%) and in the 2- to 6-month period (80%). Respiratory viruses were the most common viruses after 6 months (48%). Catheter-related candidemia was the most common fungal infection. Invasive pulmonary aspergillosis developed after 6 months. Survival rates at the first and third years were 79% and 73%, respectively. Conclusions: Although this study was performed in a single center, we provide valuable and recent detailed epidemiology data for post-LT infections. A further multicenter study is required to properly evaluate the epidemiology of post-LT infections in Korea.

Keywords

References

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