The Korean journal of internal medicine

The Korean Association of Internal Medicine (대한내과학회)
권호 표지
DOI QR코드

DOI QR Code

Drug-resistance pattern of Mycobacterium tuberculosis strains from patients with pulmonary and extrapulmonary tuberculosis during 2006 to 2013 in a Korean tertiary medical center

  • Lee, Ho Young (Division of Pulmonary, Allergy and Critical Care Medicine, Department of Internal Medicine, Inje University Busan Paik Hospital) ;
  • Lee, Jin (Division of Pulmonary, Allergy and Critical Care Medicine, Department of Internal Medicine, Inje University Busan Paik Hospital) ;
  • Lee, Young Seok (Division of Pulmonary, Allergy and Critical Care Medicine, Department of Internal Medicine, Inje University Busan Paik Hospital) ;
  • Kim, Mi-Yeong (Division of Pulmonary, Allergy and Critical Care Medicine, Department of Internal Medicine, Inje University Busan Paik Hospital) ;
  • Lee, Hyun-Kyung (Division of Pulmonary, Allergy and Critical Care Medicine, Department of Internal Medicine, Inje University Busan Paik Hospital) ;
  • Lee, Young-Min (Division of Pulmonary, Allergy and Critical Care Medicine, Department of Internal Medicine, Inje University Busan Paik Hospital) ;
  • Shin, Jeong Hwan (Department Laboratory Medicine, Inje University Busan Paik Hospital) ;
  • Ko, Yousang (Division of Pulmonary, Allergy and Critical Care Medicine, Department of Internal Medicine, Inje University Busan Paik Hospital)
  • Received : 2014.04.27
  • Accepted : 2014.07.08
  • Published : 2015.05.01
⟨ Previous Next ⟩

Abstract

Background/Aims: We evaluated the trend in the rates of drug-resistant tuberculosis (TB) over time, as well as the difference in the drug-resistance pattern between pulmonary tuberculosis (PTB) and extrapulmonary tuberculosis (EPTB) at a private referral center in South Korea. Methods: All patients with culture-confirmed TB from 2006 to 2013 were included. Results: In total, 1,745 patients were included: 1,431 (82.0%) were new cases, and 314 (18.0%) were cases treated previously; 1,610 (92.3%) were diagnosed with PTB, and 135 (7.7%) were diagnosed with EPTB. Multidrug-resistant (MDR) and extensively drug-resistant (XDR) TB were detected in 5.8% and 2.0% of new cases and in 20.1% and 8.6% of previously treated cases, respectively. The MDR TB rate during the study period decreased remarkably, whereas the MDR and XDR TB rates decreased significantly in previously treated cases. No difference in the drug-resistance rate was detected between PTB and EPTB. Conclusions: The TB drug-resistance rate, particularly that of MDR TB, remained high at a private referral hospital, and the drug-resistance rate did not decrease significantly from 2006 to 2013. This finding underscores the need for a national survey regarding the prevalence of drug-resistant TB to obtain the most accurate and current drug-resistance status in South Korea, including the private sector.

Keywords

References

  1. World Health Organization. Global tuberculosis Control: Surveillance, Planning, financing: WHO Report 2010. Geneva: World Health Organization, 2010.
  2. Gandhi NR, Nunn P, Dheda K, et al. Multidrug-resistant and extensively drug-resistant tuberculosis: a threat to global control of tuberculosis. Lancet 2010;375:1830-1843. https://doi.org/10.1016/S0140-6736(10)60410-2
  3. Park YS, Hong SJ, Boo YK, et al. The national status of tuberculosis using nationwide medical records survey of patients with tuberculosis in Korea. Tuberc Respir Dis 2012;73:48-55. https://doi.org/10.4046/trd.2012.73.1.48
  4. Kim SY, Kim HJ, Kim CK, et al. The recent status of multidrug-and extensively drug-resistant tuberculosis in Korea. Tuberc Respir Dis 2010;68:146-154. https://doi.org/10.4046/trd.2010.68.3.146
  5. Park YK, Park YS, Na KI, Cho EH, Shin SS, Kim HJ. Increased tuberculosis burden due to demographic transition in Korea from 2001 to 2010. Tuberc Respir Dis 2013;74:104-110. https://doi.org/10.4046/trd.2013.74.3.104
  6. Choi JC, Lim SY, Suh GY, et al. Drug resistance rates of Mycobacterium tuberculosis at a private referral center in Korea. J Korean Med Sci 2007;22:677-681. https://doi.org/10.3346/jkms.2007.22.4.677
  7. Bai GH, Park YK, Choi YW, et al. Trend of anti-tuberculosis drug resistance in Korea, 1994-2004. Int J Tuberc Lung Dis 2007;11:571-576.
  8. Lee SW, Jeon K, Kim KH, Min KH. Multidrug-resistant pulmonary tuberculosis among young Korean soldiers in a communal setting. J Korean Med Sci 2009;24:592-595. https://doi.org/10.3346/jkms.2009.24.4.592
  9. Peto HM, Pratt RH, Harrington TA, LoBue PA, Armstrong LR. Epidemiology of extrapulmonary tuberculosis in the United States, 1993-2006. Clin Infect Dis 2009;49:1350-1357. https://doi.org/10.1086/605559
  10. Lai CC, Liu WL, Tan CK, et al. Differences in drug resistance profiles of Mycobacterium tuberculosis isolates causing pulmonary and extrapulmonary tuberculosis in a medical centre in Taiwan, 2000-2010. Int J Antimicrob Agents 2011;38:125-129. https://doi.org/10.1016/j.ijantimicag.2011.03.016
  11. Bae E, Im JH, Kim SW, et al. Evaluation of combination of BACTEC mycobacteria growth indicator tube 960 system and Ogawa media for mycobacterial culture. Korean J Lab Med 2008;28:299-306. https://doi.org/10.3343/kjlm.2008.28.4.299
  12. World Health Organization; Stop TB Initiative (World Health Organization). The Treatment of Tuberculosis: Guidelines. 4th ed. Geneva: World Health Organization, 2010.
  13. World Health Organization. Treatment of Tuberculosis: Guidelines for National Programmes. 3rd ed. Geneva: World Health Organization, 2003.
  14. Korea Centers for Disease Control and Prevention. Guidelines for National Tuberculosis Control. Cheongwon: Korea Centers for Disease Control and Prevention, 2011.
  15. Korea Centers for Disease Control and Prevention. Annual Report on the Notified Tuberculosis in Korea. Cheongwon: Korea Centers for Disease Control and Prevention, 2012.
  16. Caminero JA. Multidrug-resistant tuberculosis: epidemiology, risk factors and case finding. Int J Tuberc Lung Dis 2010;14:382-390.
  17. Kim HJ. Current status of tuberculosis in Korea. Korean J Med 2012;82:257-262. https://doi.org/10.3904/kjm.2012.82.3.257
  18. Yoon NB, Lee SW, Park SM, et al. The current status of multidrug-resistant tuberculosis in one tertiary hospital in Busan, 2005-2009. Tuberc Respir Dis 2011;71:120-125. https://doi.org/10.4046/trd.2011.71.2.120
  19. Park YK, Park YS, Bai JY, et al. Drug resistance rate of new pulmonary tuberculosis patients treated from the private sector in 2003-2005. Tuberc Respir Dis 2008;64:87-94. https://doi.org/10.4046/trd.2008.64.2.87
  20. Lee DH, Kim SH, Kim YK. The resistance rate of anti-tuberculosis drug isolated from initial tuberculosis patients at a general hospital in Daejeon area. J Korea Acad Ind Coop Soc 2011;12:5012-5018.
  21. Kim DK, Kim MO, Kim TH, et al. The prevalence and risk factors of drug resistant pulmonary tuberculosis investigated at one university hospital in Seoul. Tuberc Respir Dis 2005;58:243-247. https://doi.org/10.4046/trd.2005.58.3.243
  22. Vishnevskii BI, Steklova LN. The rate and pattern of drug resistance in Mycobacterium tuberculosis at various sites of the disease. Probl Tuberk Bolezn Legk 2008;12:5-8.

Cited by

  1. Open surgery versus retroperitoneal laparoscopic nephrectomy for renal tuberculosis: a retrospective study of 120 patients vol.4, pp.None, 2015, https://doi.org/10.7717/peerj.2708
  2. The Rate of Drug-Resistant Tuberculosis in Korean Children and Adolescents Since 2007 vol.32, pp.6, 2015, https://doi.org/10.3346/jkms.2017.32.6.954
  3. Characteristics of Drug Resistant Tuberculosis in Sanatoria of North Korea vol.32, pp.7, 2015, https://doi.org/10.3346/jkms.2017.32.7.1105
  4. Loculated Tuberculous Pleural Effusion: Easily Identifiable and Clinically Useful Predictor of Positive Mycobacterial Culture from Pleural Fluid vol.80, pp.1, 2015, https://doi.org/10.4046/trd.2017.80.1.35
  5. Does repeated pleural culture increase the diagnostic yield of Mycobacterium tuberculosis from tuberculous pleural effusion in HIV-negative individuals? vol.12, pp.7, 2015, https://doi.org/10.1371/journal.pone.0181798
  6. Pre-immigration Screening for Tuberculosis in South Korea: A Comparison of Smear- and Culture-Based Protocols vol.82, pp.2, 2019, https://doi.org/10.4046/trd.2018.0009
  7. Clinical Validation of the QMAC-DST System for Testing the Drug Susceptibility of Mycobacterium tuberculosis to First- and Second-Line Drugs vol.10, pp.None, 2015, https://doi.org/10.3389/fmicb.2019.00706
  8. Clinical Characteristics and Treatment Outcomes of Definitive versus Standard Anti-Tuberculosis Therapy in Patients with Tuberculous Lymphadenitis vol.8, pp.6, 2015, https://doi.org/10.3390/jcm8060813
  9. Application of next-generation sequencing to detect variants of drug-resistant Mycobacterium tuberculosis : genotype–phenotype correlation vol.18, pp.1, 2015, https://doi.org/10.1186/s12941-018-0300-y
  10. Diagnosis and treatment of epididymal tuberculosis: a review of 47 cases vol.8, pp.None, 2020, https://doi.org/10.7717/peerj.8291
  11. Epidemiology of extrapulmonary tuberculosis in high-burden regions vol.98, pp.7, 2015, https://doi.org/10.21292/2075-1230-2020-98-7-37-43
  12. Molecular characterization and drug resistance patterns of Mycobacterium tuberculosis complex in extrapulmonary tuberculosis patients in Addis Ababa, Ethiopia vol.15, pp.12, 2015, https://doi.org/10.1371/journal.pone.0243493
  13. Rifampin resistance among individuals with extrapulmonary tuberculosis: 4 years of experience from a reference laboratory vol.40, pp.None, 2015, https://doi.org/10.1016/j.nmni.2021.100841