The Korean journal of internal medicine

The Korean Association of Internal Medicine (대한내과학회)
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Methods for the morphological and functional evaluation of microvascular damage in systemic sclerosis

  • Ruaro, Barbara (Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genova) ;
  • Smith, Vanessa (Department of Rheumatology, Ghent University Hospital) ;
  • Sulli, Alberto (Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genova) ;
  • Decuman, Saskia (Department of Rheumatology, Ghent University Hospital) ;
  • Pizzorni, Carmen (Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genova) ;
  • Cutolo, Maurizio (Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genova)
  • Received : 2014.08.29
  • Accepted : 2014.11.10
  • Published : 2015.01.01
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Abstract

Systemic sclerosis is a connective tissue disease characterized by alterations in microvascular structure and function. In these patients, numerous studies have demonstrated a relationship between capillary morphology and peripheral blood perfusion. Nailfold videocapillaroscopy reveals the peripheral microvascular morphology and thus allows classification and scoring of capillary abnormalities with respect to different microangiopathy patterns (early, active, and late). Laser Doppler f lowmetry and laser speckle contrast analysis can be used to estimate cutaneous blood flow through microvessels and to assess and quantify blood perfusion at peripheral sites. These two methods are also used to identify changes in digital blood perfusion after the infusion of vasodilators.

Keywords

References

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