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Acute Necrotizing Pancreatitis Associated with Mycoplasma pneumoniae Infection in a Child

  • Yang, Aram (Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
  • Kang, Ben (Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
  • Choi, So Yoon (Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
  • Cho, Joong Bum (Department of Critical Care Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
  • Kim, Yae-Jean (Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
  • Jeon, Tae Yeon (Department of Radiology, Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
  • Choe, Yon Ho (Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine)
  • Received : 2015.01.29
  • Accepted : 2015.02.24
  • Published : 2015.09.30

Abstract

Mycoplasma pneumoniae is responsible for approximately 20% to 30% of community-acquired pneumonia, and is well known for its diverse extrapulmonary manifestations. However, acute necrotizing pancreatits is an extremely rare extrapulmonary manifestation of M. pneumoniae infection. A 6-year-old girl was admitted due to abdominal pain, vomiting, fever, and confused mentality. Acute necrotizing pancreatitis was diagnosed according to symptoms, laboratory test results, and abdominal computed tomography scans. M. pneumoniae infection was diagnosed by a 4-fold increase in antibodies to M. pneumoniae between acute and convalescent sera by particle agglutination antibody assay. No other etiologic factors or pathogens were detected. Despite the occurrence of a large infected pseudocyst during the course, the patient was able to discharge without morbidity by early aggressive supportive care. This is the first case in Korea of a child with acute necrotizing pancreatitis associated with M. pneumoniae infection.

Keywords

References

  1. Mardh PA, Ursing B. The occurrence of acute pancreatitis in Mycoplasma pneumoniae infection. Scand J Infect Dis 1974;6:167-71. https://doi.org/10.3109/inf.1974.6.issue-2.11
  2. Freeman R, McMahon MJ. Acute pancreatitis and serological evidence of infection with Mycoplasma pneumoniae. Gut 1978;19:367-70. https://doi.org/10.1136/gut.19.5.367
  3. Narita M. Pathogenesis of extrapulmonary manifestations of Mycoplasma pneumoniae infection with special reference to pneumonia. J Infect Chemother 2010; 16:162-9. https://doi.org/10.1007/s10156-010-0044-X
  4. al-Abassi A. Acute pancreatitis associated with Mycoplasma pneumoniae: a case report of missed diagnosis. Med Princ Pract 2002;11:112-5. https://doi.org/10.1159/000058018
  5. Nakagawa M, Ogino H, Shimohira M, Hara M, Shibamoto Y. Continuous regional arterial infusion therapy for acute necrotizing pancreatitis due to Mycoplasma pneumoniae infection in a child. Cardiovasc Intervent Radiol 2009;32:581-4. https://doi.org/10.1007/s00270-008-9457-7
  6. Banks PA, Bollen TL, Dervenis C, Gooszen HG, Johnson CD, Sarr MG, et al; Acute Pancreatitis Classification Working Group. Classification of acute pancreatitis-- 2012: revision of the Atlanta classification and definitions by international consensus. Gut 2013;62:102-11. https://doi.org/10.1136/gutjnl-2012-302779
  7. Morinville VD, Barmada MM, Lowe ME. Increasing incidence of acute pancreatitis at an American pediatric tertiary care center: is greater awareness among physicians responsible? Pancreas 2010;39:5-8. https://doi.org/10.1097/MPA.0b013e3181baac47
  8. Benifla M, Weizman Z. Acute pancreatitis in childhood: analysis of literature data. J Clin Gastroenterol 2003; 37:169-72. https://doi.org/10.1097/00004836-200308000-00015
  9. Werlin SL, Kugathasan S, Frautschy BC. Pancreatitis in children. J Pediatr Gastroenterol Nutr 2003;37: 591-5. https://doi.org/10.1097/00005176-200311000-00017
  10. Lautz TB, Chin AC, Radhakrishnan J. Acute pancreatitis in children: spectrum of disease and predictors of severity. J Pediatr Surg 2011;46:1144-9. https://doi.org/10.1016/j.jpedsurg.2011.03.044
  11. Raizner A, Phatak UP, Baker K, Patel MG, Husain SZ, Pashankar DS. Acute necrotizing pancreatitis in children. J Pediatr 2013;162:788-92. https://doi.org/10.1016/j.jpeds.2012.09.037
  12. Suzuki M, Sai JK, Shimizu T. Acute pancreatitis in children and adolescents. World J Gastrointest Pathophysiol 2014;5:416-26. https://doi.org/10.4291/wjgp.v5.i4.416
  13. Whitcomb DC, Lowe ME. Pancreatitis: acute and chronic. In: Walker WA, ed. Pediatric gastrointestinal disease: pathophysiology, diagnosis, management. 4th ed. Hamilton: BC Decker, 2004:1584-97.
  14. Knaus WA, Draper EA, Wagner DP, Zimmerman JE. APACHE II: a severity of disease classification system. Crit Care Med 1985;13:818-29. https://doi.org/10.1097/00003246-198510000-00009
  15. Pavlidis P, Crichton S, Lemmich Smith J, Morrison D, Atkinson S, Wyncoll D, et al. Improved outcome of severe acute pancreatitis in the intensive care unit. Crit Care Res Pract 2013;2013:897107.
  16. Yasuda T, Ueda T, Takeyama Y, Shinzeki M, Sawa H, Nakajima T, et al. Treatment strategy against infection: clinical outcome of continuous regional arterial infusion, enteral nutrition, and surgery in severe acute pancreatitis. J Gastroenterol 2007;42:681-9. https://doi.org/10.1007/s00535-007-2081-5
  17. Zerem E. Treatment of severe acute pancreatitis and its complications. World J Gastroenterol 2014;20:13879-92. https://doi.org/10.3748/wjg.v20.i38.13879
  18. Chen CC, Wang SS, Lee FY. Action of antiproteases on the inflammatory response in acute pancreatitis. JOP 2007;8(4 Suppl):488-94.
  19. Chen CC, Wang SS, Tsay SH, Lee FY, Lu RH, Chang FY, et al. Effects of gabexate mesilate on serum inflammatory cytokines in rats with acute necrotizing pancreatitis. Cytokine 2006;33:95-9. https://doi.org/10.1016/j.cyto.2005.12.004
  20. Seta T, Noguchi Y, Shimada T, Shikata S, Fukui T. Treatment of acute pancreatitis with protease inhibitors: a meta-analysis. Eur J Gastroenterol Hepatol 2004;16:1287-93. https://doi.org/10.1097/00042737-200412000-00009

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