Journal of Korean Neurosurgical Society

  • 제58권3호
  • /
  • Pages.211-216
  • /
  • 2015
  • /
  • 2005-3711(pISSN)
  • /
  • 1598-7876(eISSN)
대한신경외과학회 (The Korean Neurosurgical Society)
권호 표지
DOI QR코드

DOI QR Code

Intracranial Hemangiopericytomas : A Retrospective Study of 15 Patients with a Special Review of Recurrence

  • Noh, Sung Hyun (Department of Neurosurgery, Bundang CHA Medical Center, CHA University College of Medicine) ;
  • Lim, Jae Joon (Department of Neurosurgery, Bundang CHA Medical Center, CHA University College of Medicine) ;
  • Cho, Kyung Gi (Department of Neurosurgery, Bundang CHA Medical Center, CHA University College of Medicine)
  • 투고 : 2015.03.18
  • 심사 : 2015.08.04
  • 발행 : 2015.10.28
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

Objectives : Although surgical resection is used to treat meningeal hemangiopericytoma (MHPC), there is a high risk of subsequent recurrence. This study investigated factors associated with treatment outcomes and recurrence in patients who had undergone surgical resection of intracranial MHPC. Methods : Fifteen patients underwent surgical treatments performed by one senior neurosurgeon between 1997 and 2013. Clinical data, radiologic images, surgical outcomes, recurrence, and other relevant characteristics were reviewed and analyzed. Results : Fifteen patients were included in the analysis, 12 (80%) of whom had tumors in the supratentorial region, and 3 (20%) of whom had tumors in the infratentorial region. Complete resection was achieved in all 15 patients, and 3 (20%) patients were administered radiosurgery and conventional radiotherapy after surgery as adjuvant radiotherapy. Three patients developed recurrence, 2 of whom had not received adjuvant radiotherapy. In 1 of the patients who had not received adjuvant radiotherapy, recurrence developed at the original tumor site, 81 months after surgery. The other 2 recurrences occurred at other sites, 78 and 41 months after surgery. The 5- and 10-year overall survival rates were 88.3%, while the 5- and 10-year recurrence-free survival rates were 83% and 52%, respectively. Additionally the mean Ki-67 index differed significantly between patients who did and did not develop recurrence (43% vs. 14%; p=0.001). Conclusion : Because of the high risk of MHPC recurrence, MHPC tumors should be completely resected, whenever feasible. However, even when complete resection is achieved, adjuvant radiotherapy might be necessary to prevent recurrence.

키워드

참고문헌

  1. Adegbite AB, Khan MI, Paine KW, Tan LK : The recurrence of intracranial meningiomas after surgical treatment. J Neurosurg 58 : 51-56, 1983 https://doi.org/10.3171/jns.1983.58.1.0051
  2. Alen JF, Lobato RD, Gomez PA, Boto GR, Lagares A, Ramos A, et al. : Intracranial hemangiopericytoma : study of 12 cases. Acta Neurochir (Wien) 143 : 575-586, 2001 https://doi.org/10.1007/s007010170062
  3. Bassiouni H, Asgari S, Hubschen U, Konig HJ, Stolke D : Intracranial hemangiopericytoma : treatment outcomes in a consecutive series. Zentralbl Neurochir 68 : 111-118, 2007 https://doi.org/10.1055/s-2007-981674
  4. Bastin KT, Mehta MP : Meningeal hemangiopericytoma : defining the role for radiation therapy. J Neurooncol 14 : 277-287, 1992
  5. Brunori A, Delitala A, Oddi G, Chiappetta F : Recent experience in the management of meningeal hemangiopericytomas. Tumori 83 : 856-861, 1997 https://doi.org/10.1177/030089169708300516
  6. Carella RJ, Ransohoff J, Newall J : Role of radiation therapy in the management of meningioma. Neurosurgery 10 : 332-339, 1982 https://doi.org/10.1227/00006123-198203000-00006
  7. Coffey RJ, Cascino TL, Shaw EG : Radiosurgical treatment of recurrent hemangiopericytomas of the meninges : preliminary results. J Neurosurg 78 : 903-908, 1993 https://doi.org/10.3171/jns.1993.78.6.0903
  8. Craven JP, Quigley TM, Bolen JW, Raker EJ : Current management and clinical outcome of hemangiopericytomas. Am J Surg 163 : 490-493, 1992 https://doi.org/10.1016/0002-9610(92)90394-7
  9. Dufour H, Metellus P, Fuentes S, Murracciole X, Regis J, Figarella-Branger D, et al. : Meningeal hemangiopericytoma : a retrospective study of 21 patients with special review of postoperative external radiotherapy. Neurosurgery 48 : 756-762; discussion 762-763, 2001
  10. Ecker RD, Marsh WR, Pollock BE, Kurtkaya-Yapicier O, McClelland R, Scheithauer BW, et al. : Hemangiopericytoma in the central nervous system : treatment, pathological features, and long-term follow up in 38 patients. J Neurosurg 98 : 1182-1187, 2003 https://doi.org/10.3171/jns.2003.98.6.1182
  11. Fountas KN, Kapsalaki E, Kassam M, Feltes CH, Dimopoulos VG, Robinson JS, et al. : Management of intracranial meningeal hemangiopericytomas : outcome and experience. Neurosurg Rev 29 : 145-153, 2006 https://doi.org/10.1007/s10143-005-0001-9
  12. Galanis E, Buckner JC, Scheithauer BW, Kimmel DW, Schomberg PJ, Piepgras DG : Management of recurrent meningeal hemangiopericytoma. Cancer 82 : 1915-1920, 1998 https://doi.org/10.1002/(SICI)1097-0142(19980515)82:10<1915::AID-CNCR15>3.0.CO;2-W
  13. Ghia AJ, Allen PK, Mahajan A, Penas-Prado M, McCutcheon IE, Brown PD : Intracranial hemangiopericytoma and the role of radiation therapy : a population based analysis. Neurosurgery 72 : 203-209, 2013 https://doi.org/10.1227/NEU.0b013e31827b9e68
  14. Goellner JR, Laws ER Jr, Soule EH, Okazaki H : Hemangiopericytoma of the meninges. Mayo Clinic experience. Am J Clin Pathol 70 : 375-380, 1978 https://doi.org/10.1093/ajcp/70.3.375
  15. Guthrie BL, Ebersold MJ, Scheithauer BW, Shaw EG : Meningeal hemangiopericytoma : histopathological features, treatment, and long-term follow-up of 44 cases. Neurosurgery 25 : 514-522, 1989 https://doi.org/10.1227/00006123-198910000-00003
  16. Hara M, Aoyagi M, Nagashima G, Wakimoto H, Mikami T, Yamamoto S, et al. : Recurrence in meningeal hemangiopericytomas. Surg Neurol 50 : 586-591, 1998 https://doi.org/10.1016/S0090-3019(98)00043-3
  17. Jaaskelainen J, Servo A, Haltia M, Wahlstrom T, Valtonen S : Intracranial hemangiopericytoma : radiology, surgery, radiotherapy, and outcome in 21 patients. Surg Neurol 23 : 227-236, 1985 https://doi.org/10.1016/0090-3019(85)90087-4
  18. Joseph JT, Lisle DK, Jacoby LB, Paulus W, Barone R, Cohen ML, et al. : NF2 gene analysis distinguishes hemangiopericytoma from meningioma. Am J Pathol 147 : 1450-1455, 1995
  19. Kim JH, Jung HW, Kim YS, Kim CJ, Hwang SK, Paek SH, et al. : Meningeal hemangiopericytomas : long-term outcome and biological behavior. Surg Neurol 59 : 47-53; discussion 53-54, 2003 https://doi.org/10.1016/S0090-3019(02)00917-5
  20. Koyama H, Harada A, Nakao A, Nonami T, Kurokawa T, Kaneko T, et al. : Intracranial hemangiopericytoma with metastasis to the pancreas. Case report and literature review. J Clin Gastroenterol 25 : 706-708, 1997
  21. Lal H, Sanyal B, Pant GC, Rastogi BL, Khanna NN, Udupa KN : Hemangiopericytoma : report of three cases regarding role of radiation therapy. AJR Am J Roentgenol 126 : 887-891, 1976 https://doi.org/10.2214/ajr.126.4.887
  22. Mena H, Ribas JL, Pezeshkpour GH, Cowan DN, Parisi JE : Hemangiopericytoma of the central nervous system : a review of 94 cases. Hum Pathol 22 : 84-91, 1991 https://doi.org/10.1016/0046-8177(91)90067-Y
  23. Mira JG, Chu FC, Fortner JG : The role of radiotherapy in the management of malignant hemangiopericytoma : report of eleven new cases and review of the literature. Cancer 39 : 1254-1259, 1977 https://doi.org/10.1002/1097-0142(197703)39:3<1254::AID-CNCR2820390335>3.0.CO;2-J
  24. Park BJ, Kim YI, Hong YK, Jeun SS, Lee KS, Lee YS : Clinical analysis of intracranial hemangiopericytoma. J Korean Neurosurg Soc 54 : 309-316, 2013 https://doi.org/10.3340/jkns.2013.54.4.309
  25. Pitkethly DT, Hardman JM, Kempe LG, Earle KM : Angioblastic meningiomas; clinicopathologic study of 81 cases. J Neurosurg 32 : 539-544, 1970 https://doi.org/10.3171/jns.1970.32.5.0539
  26. Ramsey HJ : Fine structure of hemangiopericytoma and hemangio-endothelioma. Cancer 19 : 2005-2018, 1966 https://doi.org/10.1002/1097-0142(196612)19:12<2005::AID-CNCR2820191227>3.0.CO;2-X
  27. Rutkowski MJ, Jian BJ, Bloch O, Chen C, Sughrue ME, Tihan T, et al. : Intracranial hemangiopericytoma : clinical experience and treatment considerations in a modern series of 40 adult patients. Cancer 118 : 1628-1636, 2012 https://doi.org/10.1002/cncr.26411
  28. Schiariti M, Goetz P, El-Maghraby H, Tailor J, Kitchen N : Hemangiopericytoma : long-term outcome revisited. Clinical article. J Neurosurg 114 : 747-755, 2011 https://doi.org/10.3171/2010.6.JNS091660
  29. Soyuer S, Chang EL, Selek U, McCutcheon IE, Maor MH : Intracranial meningeal hemangiopericytoma : the role of radiotherapy : report of 29 cases and review of the literature. Cancer 100 : 1491-1497, 2004 https://doi.org/10.1002/cncr.20109
  30. Staples JJ, Robinson RA, Wen BC, Hussey DH : Hemangiopericytoma-- the role of radiotherapy. Int J Radiat Oncol Biol Phys 19 : 445-451, 1990 https://doi.org/10.1016/0360-3016(90)90556-Y
  31. Stessin AM, Sison C, Nieto J, Raifu M, Li B : The role of postoperative radiation therapy in the treatment of meningeal hemangiopericytoma-experience from the SEER database. Int J Radiat Oncol Biol Phys 85 : 784-790, 2013 https://doi.org/10.1016/j.ijrobp.2012.05.042
  32. Stout AP, Murray MR : Hemangiopericytoma : a vascular tumor featuring Zimmermann's pericytes. Ann Surg 116 : 26-33, 1942 https://doi.org/10.1097/00000658-194207000-00004
  33. Sundaram C, Uppin SG, Uppin MS, Rekha JS, Panigrahi MK, Purohit AK, et al. : A clinicopathological and immunohistochemical study of central nervous system hemangiopericytomas. J Clin Neurosci 17 : 469-472, 2010 https://doi.org/10.1016/j.jocn.2009.08.018
  34. Vuorinen V, Sallinen P, Haapasalo H, Visakorpi T, Kallio M, Jaaskelainen J : Outcome of 31 intracranial haemangiopericytomas : poor predictive value of cell proliferation indices. Acta Neurochir (Wien) 138 : 1399-1408, 1996 https://doi.org/10.1007/BF01411118
  35. Uemura S, Kuratsu J, Hamada J, Yoshioka S, Kochi M, Ushio Y, et al. : Effect of radiation therapy against intracranial hemangiopericytoma. Neurol Med Chir (Tokyo) 32 : 328-332, 1992 https://doi.org/10.2176/nmc.32.328

피인용 문헌

  1. Surveillance for metastatic hemangiopericytoma-solitary fibrous tumors-systematic literature review on incidence, predictors and diagnosis of extra-cranial disease vol.138, pp.3, 2015, https://doi.org/10.1007/s11060-018-2836-2
  2. Intracranial solitary fibrous tumors/hemangiopericytomas: first report of malignant progression vol.128, pp.6, 2018, https://doi.org/10.3171/2017.1.jns162593
  3. Intracranial solitary fibrous tumors/hemangiopericytomas: first report of malignant progression vol.128, pp.6, 2018, https://doi.org/10.3171/2017.1.jns162593
  4. Reappraisal of morphological and immunohistochemical spectrum of intracranial and spinal solitary fibrous tumors/hemangiopericytomas with impact on long-term follow-up vol.55, pp.3, 2018, https://doi.org/10.4103/ijc.ijc_631_17
  5. The radiation therapy options of intracranial hemangiopericytoma: An overview and update on a rare vascular mesenchymal tumor vol.12, pp.2, 2015, https://doi.org/10.4081/oncol.2018.354
  6. Solitary fibrous tumor/hemangiopericytoma: treatment results based on the 2016 WHO classification vol.130, pp.2, 2015, https://doi.org/10.3171/2017.9.jns171057
  7. Solitary fibrous tumor/hemangiopericytoma: treatment results based on the 2016 WHO classification vol.130, pp.2, 2015, https://doi.org/10.3171/2017.9.jns171057
  8. A review of solitary fibrous tumor/hemangiopericytoma tumor and a comparison of risk factors for recurrence, metastases, and death among patients with spinal and intracranial tumors. vol.44, pp.3, 2021, https://doi.org/10.1007/s10143-020-01335-x