Tuberculosis and Respiratory Diseases

The Korean Academy of Tuberculosis and Respiratory Diseases (대한결핵및호흡기학회)
권호 표지
DOI QR코드

DOI QR Code

Nontuberculous Mycobacterial Lung Disease Caused by Mycobacterium simiae: The First Reported Case in South Korea

  • Jeong, Suk Hyeon (Division of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
  • Kim, Su-Young (Division of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
  • Lee, Hyun (Division of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
  • Ham, Jun Soo (Division of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
  • Hwang, Keum Bit (Division of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
  • Hwang, Subin (Division of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
  • Shin, Sun Hye (Division of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
  • Chung, Myung Jin (Department of Radiology, Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
  • Lee, Seung Heon (Korean Institute of Tuberculosis) ;
  • Shin, Sung Jae (Department of Microbiology, Yonsei University College of Medicine) ;
  • Koh, Won-Jung (Division of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine)
  • Received : 2015.07.26
  • Accepted : 2015.08.28
  • Published : 2015.10.30
Download PDF
⟨ Previous Next ⟩

Abstract

This is a report of the first South Korean case of a lung disease caused by Mycobacterium simiae. The patient was a previously healthy 52-year-old female. All serial isolates were identified as M. simiae by multi-locus sequencing analysis, based on hsp65, rpoB, 16S-23S rRNA internal transcribed spacer, and 16S rRNA fragments. A chest radiography revealed deterioration, and the follow-up sputum cultures were persistently positive, despite combination antibiotic treatment, including azithromycin, ethambutol, and rifampin. To the best of our knowledge, this is the first confirmed case of a lung disease caused by M. simiae in South Korea.

Keywords

References

  1. Griffith DE, Aksamit T, Brown-Elliott BA, Catanzaro A, Daley C, Gordin F, et al. An official ATS/IDSA statement: diagnosis, treatment, and prevention of nontuberculous mycobacterial diseases. Am J Respir Crit Care Med 2007;175:367-416. https://doi.org/10.1164/rccm.200604-571ST
  2. Maoz C, Shitrit D, Samra Z, Peled N, Kaufman L, Kramer MR, et al. Pulmonary Mycobacterium simiae infection: comparison with pulmonary tuberculosis. Eur J Clin Microbiol Infect Dis 2008;27:945-50. https://doi.org/10.1007/s10096-008-0522-6
  3. Velayati AA, Farnia P, Mozafari M, Malekshahian D, Seif S, Rahideh S, et al. Molecular epidemiology of nontuberculous mycobacteria isolates from clinical and environmental sources of a metropolitan city. PLoS One 2014;9:e114428. https://doi.org/10.1371/journal.pone.0114428
  4. van Ingen J, Boeree MJ, Dekhuijzen PN, van Soolingen D. Clinical relevance of Mycobacterium simiae in pulmonary samples. Eur Respir J 2008;31:106-9. https://doi.org/10.1183/09031936.00076107
  5. Wang HY, Bang H, Kim S, Koh WJ, Lee H. Identification of Mycobacterium species in direct respiratory specimens using reverse blot hybridisation assay. Int J Tuberc Lung Dis 2014; 18:1114-20. https://doi.org/10.5588/ijtld.14.0140
  6. Ben Salah I, Adekambi T, Raoult D, Drancourt M. rpoB sequence- based identification of Mycobacterium avium complex species. Microbiology 2008;154:3715-23. https://doi.org/10.1099/mic.0.2008/020164-0
  7. Frothingham R, Wilson KH. Sequence-based differentiation of strains in the Mycobacterium avium complex. J Bacteriol 1993;175:2818-25. https://doi.org/10.1128/jb.175.10.2818-2825.1993
  8. Turenne CY, Tschetter L, Wolfe J, Kabani A. Necessity of quality- controlled 16S rRNA gene sequence databases: identifying nontuberculous Mycobacterium species. J Clin Microbiol 2001;39:3637-48. https://doi.org/10.1128/JCM.39.10.3638-3648.2001
  9. Adekambi T, Colson P, Drancourt M. rpoB-based identification of nonpigmented and late-pigmenting rapidly growing mycobacteria. J Clin Microbiol 2003;41:5699-708. https://doi.org/10.1128/JCM.41.12.5699-5708.2003
  10. Clinical Laboratory Standards Institute. Susceptibility testing of mycobacteria, nocardiae, and other aerobic actinomycetes; approved standard. 2nd ed. CLSI document No. M24-A2. Wayne: Clinical Laboratory Standards Institute; 2011.
  11. Meier A, Heifets L, Wallace RJ Jr, Zhang Y, Brown BA, Sander P, et al. Molecular mechanisms of clarithromycin resistance in Mycobacterium avium : observation of multiple 23S rDNA mutations in a clonal population. J Infect Dis 1996;174:354-60. https://doi.org/10.1093/infdis/174.2.354
  12. El Sahly HM, Septimus E, Soini H, Septimus J, Wallace RJ, Pan X, et al. Mycobacterium simiae pseudo-outbreak resulting from a contaminated hospital water supply in Houston, Texas. Clin Infect Dis 2002;35:802-7. https://doi.org/10.1086/342331
  13. Baghaei P, Tabarsi P, Farnia P, Marjani M, Sheikholeslami FM, Chitsaz M, et al. Pulmonary disease caused by Mycobacterium simiae in Iran's national referral center for tuberculosis. J Infect Dev Ctries 2012;6:23-8.
  14. van Ingen J, Totten SE, Heifets LB, Boeree MJ, Daley CL. Drug susceptibility testing and pharmacokinetics question current treatment regimens in Mycobacterium simiae complex disease. Int J Antimicrob Agents 2012;39:173-6. https://doi.org/10.1016/j.ijantimicag.2011.09.019
  15. van Ingen J, van der Laan T, Dekhuijzen R, Boeree M, van Soolingen D. In vitro drug susceptibility of 2275 clinical nontuberculous Mycobacterium isolates of 49 species in The Netherlands. Int J Antimicrob Agents 2010;35:169-73. https://doi.org/10.1016/j.ijantimicag.2009.09.023

Cited by

  1. Treatment of Non-Tuberculous Mycobacterial Lung Disease vol.8, pp.4, 2015, https://doi.org/10.1007/s40506-016-0086-4
  2. Drug Susceptibility of 33 Reference Strains of Slowly Growing Mycobacteria to 19 Antimicrobial Agents vol.2017, pp.None, 2015, https://doi.org/10.1155/2017/1584658
  3. Draft Genome Sequence of Mycobacterium simiae, a Potential Pathogen Isolated from the Normal Human Oral Cavity vol.9, pp.46, 2015, https://doi.org/10.1128/mra.01185-20