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Nontuberculous Mycobacterial Lung Disease Caused by Mycobacterium shinjukuense: The First Reported Case in Korea

  • Moon, Seong Mi (Division of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
  • Kim, Su-Young (Division of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
  • Chung, Myung Jin (Department of Radiology, Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
  • Lee, Seung Heon (Korean Institute of Tuberculosis) ;
  • Shin, Sung Jae (Department of Microbiology, Yonsei University College of Medicine) ;
  • Koh, Won-Jung (Division of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine)
  • Received : 2015.03.26
  • Accepted : 2015.06.25
  • Published : 2015.10.30

Abstract

Mycobacterium shinjukuense is a novel species of nontuberculous mycobacteria (NTM) that was first reported in Japan in 2011. It is a slow-growing NTM pathogen that can cause chronic pulmonary infections. There are only a few reported cases of M. shinjukuense infections, all of which are from Japan. We reported a case of chronic lung disease caused by M. shinjukuense. The organism was identified by 16S rRNA, rpoB, and hsp65 gene sequencing. To the best of our knowledge, this was the first confirmed case of lung disease caused by M. shinjukuense outside of Japan.

Keywords

References

  1. Kendall BA, Winthrop KL. Update on the epidemiology of pulmonary nontuberculous mycobacterial infections. Semin Respir Crit Care Med 2013;34:87-94. https://doi.org/10.1055/s-0033-1333567
  2. Morimoto K, Iwai K, Uchimura K, Okumura M, Yoshiyama T, Yoshimori K, et al. A steady increase in nontuberculous mycobacteriosis mortality and estimated prevalence in Japan. Ann Am Thorac Soc 2014;11:1-8. https://doi.org/10.1513/AnnalsATS.201303-067OC
  3. Koh WJ, Chang B, Jeong BH, Jeon K, Kim SY, Lee NY, et al. Increasing recovery of nontuberculous mycobacteria from respiratory specimens over a 10-year period in a tertiary referral hospital in South Korea. Tuberc Respir Dis 2013;75:199-204. https://doi.org/10.4046/trd.2013.75.5.199
  4. Kwon YS, Koh WJ. Diagnosis of pulmonary tuberculosis and nontuberculous mycobacterial lung disease in Korea. Tuberc Respir Dis 2014;77:1-5. https://doi.org/10.4046/trd.2014.77.1.1
  5. Griffith DE, Aksamit T, Brown-Elliott BA, Catanzaro A, Daley C, Gordin F, et al. An official ATS/IDSA statement: diagnosis, treatment, and prevention of nontuberculous mycobacterial diseases. Am J Respir Crit Care Med 2007;175:367-416. https://doi.org/10.1164/rccm.200604-571ST
  6. Saito H, Iwamoto T, Ohkusu K, Otsuka Y, Akiyama Y, Sato S, et al. Mycobacterium shinjukuense sp. nov., a slowly growing, non-chromogenic species isolated from human clinical specimens. Int J Syst Evol Microbiol 2011;61:1927-32. https://doi.org/10.1099/ijs.0.025478-0
  7. Futatsugi K, Nishio K, Aida S, Okabayashi K, Nakano Y, Ryuzaki M, et al. Case report: a case of pulmonary infectious disease due to Mycobacterium shinjukuense . Nihon Naika Gakkai Zasshi 2011;100:3637-9. https://doi.org/10.2169/naika.100.3637
  8. Watanabe K, Shinkai M, Yamaguchi N, Shinoda M, Hara Y, Ishigatsubo Y, et al. Mycobacterium shinjukuense lung disease that was successfully treated with antituberculous drugs. Intern Med 2013;52:2653-5. https://doi.org/10.2169/internalmedicine.52.1116
  9. Oshima K, Yokouchi H, Minemura H, Saito J, Tanino Y, Munakata M. Pulmonary infection caused by Mycobacterium shinjukuense . Ann Am Thorac Soc 2015;12:958-9. https://doi.org/10.1513/AnnalsATS.201503-124LE
  10. Wang HY, Bang H, Kim S, Koh WJ, Lee H. Identification of Mycobacterium species in direct respiratory specimens using reverse blot hybridisation assay. Int J Tuberc Lung Dis 2014; 18:1114-20. https://doi.org/10.5588/ijtld.14.0140
  11. Wang HY, Kim H, Kim S, Kim DK, Cho SN, Lee H. Performance of a real-time PCR assay for the rapid identification of Mycobacterium species. J Microbiol 2015;53:38-46. https://doi.org/10.1007/s12275-015-4495-8
  12. Turenne CY, Tschetter L, Wolfe J, Kabani A. Necessity of quality- controlled 16S rRNA gene sequence databases: identifying nontuberculous Mycobacterium species. J Clin Microbiol 2001;39:3637-48. https://doi.org/10.1128/JCM.39.10.3638-3648.2001
  13. Telenti A, Marchesi F, Balz M, Bally F, Bottger EC, Bodmer T. Rapid identification of mycobacteria to the species level by polymerase chain reaction and restriction enzyme analysis. J Clin Microbiol 1993;31:175-8.
  14. Devulder G, Perouse de Montclos M, Flandrois JP. A multigene approach to phylogenetic analysis using the genus Mycobacterium as a model. Int J Syst Evol Microbiol 2005;55(Pt 1):293-302. https://doi.org/10.1099/ijs.0.63222-0
  15. Somoskovi A, Salfinger M. Nontuberculous mycobacteria in respiratory infections: advances in diagnosis and identification. Clin Lab Med 2014;34:271-95. https://doi.org/10.1016/j.cll.2014.03.001

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